Detailed information NTG0139092

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: RU53_RS10385
• Genome accession: NZ_CP010526
• Coordinates: 2057422..2058465 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus subsp. aureus ST772-MRSA-V strain DAR4145
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2052422..2063465

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
RU53_RS10355 (RU53_2011)	-	2052844..2054100 (-)	1257	WP_075583716.1	aminopeptidase	-
RU53_RS10360 (RU53_2012)	-	2054103..2054303 (-)	201	WP_000180460.1	DUF1128 family protein	-
RU53_RS10365 (RU53_2013)	-	2054450..2054914 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
RU53_RS10370 (RU53_2014)	-	2054921..2055196 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
RU53_RS10375 (RU53_2015)	-	2055474..2056691 (+)	1218	WP_000037078.1	YihY/virulence factor BrkB family protein	-
RU53_RS10380 (RU53_2016)	vraR	2056803..2057432 (-)	630	WP_000153528.1	two-component system response regulator VraR	Regulator
RU53_RS10385 (RU53_2017)	vraS	2057422..2058465 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
RU53_RS10390 (RU53_2018)	liaF	2058462..2059163 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
RU53_RS10395 (RU53_2019)	-	2059178..2059564 (-)	387	WP_001110179.1	hypothetical protein	-
RU53_RS10400 (RU53_2020)	map	2059781..2060539 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
RU53_RS10410 (RU53_2021)	-	2061011..2061997 (+)	987	WP_000999718.1	FUSC family protein	-
RU53_RS10415 (RU53_2022)	-	2062428..2062841 (-)	414	WP_001837637.1	hypothetical protein	-
RU53_RS15550	-	2062870..2062980 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=139092 RU53_RS10385 WP_001017131.1 2057422..2058465(-) (vraS) [Staphylococcus aureus subsp. aureus ST772-MRSA-V strain DAR4145]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=139092 RU53_RS10385 WP_001017131.1 2057422..2058465(-) (vraS) [Staphylococcus aureus subsp. aureus ST772-MRSA-V strain DAR4145]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1