Detailed information NTG0136039

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: RM27_RS09450
• Genome accession: NZ_CP010299
• Coordinates: 2026217..2027260 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain ATCC BAA1680
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2021217..2032260

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
RM27_RS09420 (RM27_10145)	-	2021635..2022891 (-)	1257	WP_001795438.1	aminopeptidase	-
RM27_RS09425 (RM27_10150)	-	2022894..2023094 (-)	201	WP_000180461.1	DUF1128 family protein	-
RM27_RS09430 (RM27_10155)	-	2023241..2023705 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
RM27_RS09435 (RM27_10160)	-	2023712..2023987 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
RM27_RS09440 (RM27_10165)	-	2024265..2025482 (+)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
RM27_RS09445 (RM27_10170)	vraR	2025598..2026227 (-)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
RM27_RS09450 (RM27_10175)	vraS	2026217..2027260 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
RM27_RS09455 (RM27_10180)	liaF	2027257..2027958 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
RM27_RS09460 (RM27_10185)	-	2027973..2028359 (-)	387	WP_001110179.1	hypothetical protein	-
RM27_RS09465 (RM27_10190)	map	2028576..2029334 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
RM27_RS09470 (RM27_10200)	-	2029862..2030848 (+)	987	WP_000999713.1	FUSC family protein	-
RM27_RS09480 (RM27_10210)	-	2031397..2031810 (-)	414	WP_001549145.1	hypothetical protein	-
RM27_RS14670 (RM27_10215)	-	2031839..2031949 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=136039 RM27_RS09450 WP_001017131.1 2026217..2027260(-) (vraS) [Staphylococcus aureus strain ATCC BAA1680]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=136039 RM27_RS09450 WP_001017131.1 2026217..2027260(-) (vraS) [Staphylococcus aureus strain ATCC BAA1680]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTTTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1