Detailed information NTG0122177

Bioinformatically predicted

Overview

• Name: dsbA2
• Type: Machinery gene
• Locus tag: B6116_RS00805
• Genome accession: NZ_CP007667
• Coordinates: 153490..154185 (-)
• Length: 231 a.a.
• NCBI ID: WP_002215704.1
• Uniprot ID: Q7DDR6
• Organism: Neisseria meningitidis strain B6116/77
• Function: DNA binding and uptake; interact with PilQ (predicted from homology) DNA binding and uptake

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
Genomic island	138023..155015	153490..154185	within	0

Gene organization within MGE regions

Location: 138023..155015

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
B6116_RS00715 (B6116_00131)	-	139515..139760 (-)	246	WP_002226028.1	hypothetical protein	-
B6116_RS00725 (B6116_00132)	-	139872..140300 (+)	429	WP_002226027.1	CopD family protein	-
B6116_RS00730 (B6116_00133)	-	140312..140788 (+)	477	WP_002226026.1	CYTH domain-containing protein	-
B6116_RS00735 (B6116_00134)	-	141138..141626 (-)	489	WP_002226025.1	dihydrofolate reductase	-
B6116_RS00740 (B6116_00135)	aroG	141694..142749 (-)	1056	WP_002226024.1	3-deoxy-7-phosphoheptulonate synthase AroG	-
B6116_RS14335	-	142911..143138 (-)	228	WP_153310284.1	hypothetical protein	-
B6116_RS00750 (B6116_00136)	-	143365..143673 (+)	309	WP_017629289.1	membrane protein	-
B6116_RS14625	-	143722..143826 (-)	105	Protein_135	IS1595 family transposase	-
B6116_RS00760 (B6116_00138)	comE	144501..144965 (-)	465	WP_014580830.1	helix-hairpin-helix domain-containing protein	Machinery gene
B6116_RS00795 (B6116_00144)	-	150763..151569 (-)	807	WP_002221447.1	cytochrome C assembly family protein	-
B6116_RS00800 (B6116_00145)	ffh	151789..153159 (+)	1371	WP_002221448.1	signal recognition particle protein	-
B6116_RS00805 (B6116_00146)	dsbA2	153490..154185 (-)	696	WP_002215704.1	thiol:disulfide interchange protein DsbA/DsbL	Machinery gene
B6116_RS00810 (B6116_00147)	-	154356..155015 (-)	660	WP_002218694.1	NYN domain-containing protein	-

Sequence

Protein

• Length: 231 a.a.
• Molecular weight: 25419.90 Da
• Isoelectric Point: 5.1502

>NTDB_id=122177 B6116_RS00805 WP_002215704.1 153490..154185(-) (dsbA2) [Neisseria meningitidis strain B6116/77]
MKLKTLALTSLTLLALAACSKQAETSVPADSAQSSSSAPAAPAELNEGVNYTVLSTPIPQQQAGKIEVLEFFGYFCPHCA
HLEPVLSEHIKTFKDDTYMRREHVVWGDEMKPLARLAAAVEMAGESDKANSHIFDAMVNQKINLADTDTLKKWLSEQTAF
DGKKVLAAFEAPESQARAAQMEELTNKFQISGTPTVIVGGKYQVEFKDWQSGMTTIDQLVDKVREEQKKPQ

Nucleotide

• Length: 696 bp

>NTDB_id=122177 B6116_RS00805 WP_002215704.1 153490..154185(-) (dsbA2) [Neisseria meningitidis strain B6116/77]
ATGAAACTGAAAACCTTAGCTTTGACTTCATTGACCCTGTTGGCATTGGCCGCTTGTAGCAAACAGGCTGAAACCAGTGT
TCCGGCAGACAGCGCCCAAAGCAGCTCATCTGCTCCGGCAGCCCCTGCTGAGTTGAACGAAGGTGTGAACTACACTGTAT
TGTCTACGCCTATTCCGCAACAGCAGGCCGGTAAAATCGAAGTATTGGAATTTTTCGGCTACTTCTGCCCGCATTGCGCC
CATCTTGAGCCGGTCTTGAGCGAGCACATCAAAACGTTTAAAGACGATACCTATATGCGCCGGGAGCATGTCGTGTGGGG
TGATGAAATGAAACCTTTGGCACGTTTGGCGGCCGCAGTGGAAATGGCCGGTGAATCAGATAAAGCCAACAGCCATATTT
TCGATGCGATGGTTAATCAAAAAATCAATCTGGCCGATACCGATACCCTGAAAAAATGGCTGTCCGAGCAAACAGCGTTT
GACGGCAAAAAAGTATTGGCTGCATTTGAGGCTCCTGAAAGCCAAGCGCGTGCGGCTCAAATGGAAGAGTTGACCAATAA
ATTCCAAATCAGCGGCACACCGACTGTGATTGTCGGCGGCAAATACCAAGTTGAATTTAAAGACTGGCAGTCTGGTATGA
CCACGATTGACCAGTTGGTGGATAAAGTACGCGAAGAGCAGAAAAAGCCGCAATAA

Domains

Predicted by InterproScan.

• Thioredoxin (Thioredoxin_4) (65-212)

3D structure

• AlphaFold DB: Q7DDR6

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
dsbA2	Neisseria meningitidis MC58	100	100	1
dsbA1	Neisseria meningitidis MC58	71.245	100	0.719