Detailed information NTG0120902

Bioinformatically predicted

Overview

• Name: vicK
• Type: Regulator
• Locus tag: DK92_RS06590
• Genome accession: NZ_CP007561
• Coordinates: 1344951..1346303 (-)
• Length: 450 a.a.
• NCBI ID: WP_002990673.1
• Uniprot ID: A0A660A508
• Organism: Streptococcus pyogenes strain NGAS596
• Function: repress comCDE expression; repress comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 1339951..1351303

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DK92_RS06580 (DK92_06760)	rnc	1343003..1343695 (-)	693	WP_002990670.1	ribonuclease III	-
DK92_RS06585 (DK92_06765)	vicX	1344138..1344947 (-)	810	WP_002985641.1	MBL fold metallo-hydrolase	Regulator
DK92_RS06590 (DK92_06770)	vicK	1344951..1346303 (-)	1353	WP_002990673.1	cell wall metabolism sensor histidine kinase VicK	Regulator
DK92_RS06595 (DK92_06775)	vicR	1346296..1347006 (-)	711	WP_002985645.1	response regulator YycF	Regulator
DK92_RS06600 (DK92_06780)	-	1347168..1348202 (-)	1035	WP_172448820.1	DUF3114 domain-containing protein	-
DK92_RS06605 (DK92_06785)	-	1348258..1349505 (-)	1248	WP_014407393.1	AMP-binding protein	-
DK92_RS06610 (DK92_06790)	-	1349462..1350610 (-)	1149	WP_032464243.1	acetyl-CoA C-acyltransferase	-
DK92_RS06615 (DK92_06795)	-	1351005..1351154 (-)	150	WP_047235923.1	hypothetical protein	-

Sequence

Protein

• Length: 450 a.a.
• Molecular weight: 51391.82 Da
• Isoelectric Point: 5.4026

>NTDB_id=120902 DK92_RS06590 WP_002990673.1 1344951..1346303(-) (vicK) [Streptococcus pyogenes strain NGAS596]
MTRDIIGNLSTFELAILILLVFVAFYFIHLAVRDYRNARIIRMMSHKIRDLINGRYTDIIDEKADIELMELSDQLNDLSD
VFRLTHENLAQEKNRLASILAYMSDGVLATDRSGKIIMINETARKQLNLSKEEALKKNITDLLEGDTSYTYRDLVSKTPV
VTVNSRNDMGEFVSLRLRFALNRRESGFISGLVVVLHDTTEQEKEERERRLFVSNVSHELRTPLTSVKSYLEALDEGALK
EDIAPSFIKVSLDETNRMMRMISDLLNLSRIDNQVTQLAVEMTNFTAFITSILNRFDLVKNQHTGTGKVYEIVRDYPITS
VWLEIDNDKMTQVIENILNNAIKYSPDGGKITVRMKTTDTQLIISISDQGLGIPKTDLPLIFDRFYRVDKARSRAQGGTG
LGLAIAKEIIKQHHGFIWAKSDYGKGSTFTIVLPYEKDAAIYEEWEEDVD

Nucleotide

• Length: 1353 bp

>NTDB_id=120902 DK92_RS06590 WP_002990673.1 1344951..1346303(-) (vicK) [Streptococcus pyogenes strain NGAS596]
ATGACTAGAGATATCATTGGAAACTTATCCACATTTGAATTAGCGATCCTTATCTTACTTGTTTTTGTTGCTTTTTACTT
TATCCATCTTGCGGTGCGTGATTACCGAAATGCACGTATTATTCGGATGATGAGCCATAAAATCCGAGACTTGATTAATG
GTCGCTATACTGATATAATCGACGAAAAAGCAGACATTGAGTTAATGGAGCTTTCAGACCAGTTAAATGACCTGTCAGAT
GTTTTTCGCTTGACGCATGAAAATCTTGCCCAAGAAAAAAATCGCTTGGCAAGTATTTTGGCTTATATGTCAGATGGTGT
ACTTGCTACAGACCGGTCTGGTAAAATCATCATGATTAACGAGACAGCTCGCAAGCAATTAAATTTAAGTAAAGAAGAGG
CACTAAAGAAAAACATTACAGATTTGTTAGAAGGTGATACTTCATATACCTACCGTGATTTGGTATCCAAAACACCAGTG
GTAACTGTTAATAGCCGAAATGATATGGGTGAGTTTGTTTCATTACGCTTGCGTTTTGCGTTGAATAGGAGAGAGAGTGG
TTTTATTTCGGGCTTGGTTGTGGTGCTCCATGACACCACAGAACAAGAAAAAGAAGAACGTGAACGCCGTCTTTTTGTTT
CTAATGTAAGTCATGAATTAAGGACCCCTTTAACTTCGGTTAAATCCTACTTGGAGGCTCTTGATGAAGGTGCACTTAAA
GAAGATATTGCTCCAAGTTTCATAAAAGTTTCTCTTGATGAAACTAATCGGATGATGCGTATGATTTCAGATCTTTTAAA
CCTGTCTCGGATTGATAATCAAGTAACCCAATTAGCAGTAGAGATGACTAATTTTACTGCTTTTATAACTTCTATTTTAA
ACAGATTTGATTTGGTTAAAAATCAGCATACAGGTACAGGAAAAGTCTATGAAATTGTAAGAGATTACCCTATTACCTCT
GTCTGGCTTGAAATTGATAATGATAAAATGACACAGGTTATCGAGAATATTTTGAACAATGCCATTAAGTATTCTCCAGA
TGGTGGAAAAATTACAGTCCGTATGAAAACAACAGATACCCAATTAATTATTTCCATTTCAGACCAAGGACTAGGTATCC
CTAAAACAGATTTGCCTCTTATTTTTGATCGGTTCTATCGTGTAGACAAGGCAAGAAGTCGTGCCCAAGGAGGGACCGGT
CTAGGCCTTGCCATTGCTAAAGAAATCATCAAGCAGCACCATGGCTTTATCTGGGCTAAGAGTGACTATGGTAAAGGATC
GACCTTTACTATTGTCTTGCCTTATGAAAAAGATGCAGCCATCTATGAAGAATGGGAGGAAGATGTAGACTAA

Domains

Predicted by InterproScan.

• His Kinase A (phospho-acceptor) domain (HisKA) (209-273)

• PAS fold (PAS) (95-162)

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (326-436)

3D structure

• AlphaFold DB: A0A660A508

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vicK	Streptococcus mutans UA159	72.705	92	0.669
micB	Streptococcus pneumoniae Cp1015	67.765	94.444	0.64