Detailed information    

insolico Bioinformatically predicted

Overview

Name   crp   Type   Regulator
Locus tag   NTHI723_RS03245 Genome accession   NZ_CP007472
Coordinates   678651..679325 (-) Length   224 a.a.
NCBI ID   WP_005647998.1    Uniprot ID   Q4QLV0
Organism   Haemophilus influenzae strain 723     
Function   promote expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 673651..684325
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  NTHI723_RS03225 (NTHI723_00651) hinT 675359..675709 (+) 351 WP_005627389.1 purine nucleoside phosphoramidase -
  NTHI723_RS03230 (NTHI723_00652) - 675709..676059 (+) 351 WP_005647993.1 DUF1425 domain-containing protein -
  NTHI723_RS03235 (NTHI723_00653) nagZ 676063..677118 (+) 1056 WP_021034786.1 beta-N-acetylhexosaminidase -
  NTHI723_RS03240 (NTHI723_00654) rlmC 677111..678286 (+) 1176 WP_021034785.1 23S rRNA (uracil(747)-C(5))-methyltransferase RlmC -
  NTHI723_RS03245 (NTHI723_00655) crp 678651..679325 (-) 675 WP_005647998.1 cAMP-activated global transcriptional regulator CRP Regulator
  NTHI723_RS03250 (NTHI723_00656) - 679310..679561 (-) 252 WP_005647999.1 YheU family protein -
  NTHI723_RS03255 (NTHI723_00657) slmA 679583..680239 (-) 657 WP_005648000.1 nucleoid occlusion factor SlmA -
  NTHI723_RS03260 (NTHI723_00658) dut 680243..680698 (-) 456 WP_005631431.1 dUTP diphosphatase -
  NTHI723_RS03265 (NTHI723_00659) coaBC 680746..681948 (-) 1203 WP_011272308.1 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase CoaBC -
  NTHI723_RS03270 (NTHI723_00660) radC 682111..682776 (+) 666 WP_013526173.1 DNA repair protein RadC -
  NTHI723_RS03275 (NTHI723_00661) rpmB 682990..683226 (+) 237 WP_005542826.1 50S ribosomal protein L28 -
  NTHI723_RS03280 (NTHI723_00662) rpmG 683238..683408 (+) 171 WP_005613503.1 50S ribosomal protein L33 -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25151.85 Da        Isoelectric Point: 6.8375

>NTDB_id=119760 NTHI723_RS03245 WP_005647998.1 678651..679325(-) (crp) [Haemophilus influenzae strain 723]
MSNELTEIDEVVTSSQEEATQRDPVLDWFLTHCHLHKYPAKSTLIHAGEDATTLYYVIKGSVMVSSKDDEGKEMILTYLG
AGQFFGEAGLFDEGSKRSAWVKTKTTCEIAEISYKKYRQLIQANPEILMFLTAQLARRLQNTSRQVTNLAFLDVAGRIAQ
TLMNLAKQPEAMTHPDGMQIKITRQEIGQMVGCSRETVGRIIKMLEDQNLIHAHGKTIVVYGAR

Nucleotide


Download         Length: 675 bp        

>NTDB_id=119760 NTHI723_RS03245 WP_005647998.1 678651..679325(-) (crp) [Haemophilus influenzae strain 723]
ATGTCAAATGAATTAACCGAAATTGATGAAGTTGTAACCTCCTCTCAAGAAGAAGCAACTCAACGAGATCCCGTTTTAGA
TTGGTTTCTTACTCACTGCCATTTGCATAAATATCCTGCAAAATCAACTTTAATTCATGCTGGGGAAGATGCGACCACGC
TGTATTATGTAATTAAAGGTTCTGTAATGGTATCTTCAAAAGATGATGAAGGCAAAGAGATGATCCTCACTTACTTAGGA
GCAGGACAATTTTTTGGCGAAGCGGGATTATTTGATGAAGGTTCAAAACGATCAGCTTGGGTAAAAACAAAAACAACATG
TGAAATTGCTGAAATTTCCTATAAGAAATATCGCCAGTTGATTCAGGCAAACCCTGAAATCTTAATGTTTCTCACTGCAC
AATTGGCAAGACGTTTGCAAAATACATCACGTCAAGTCACGAATTTGGCATTTTTGGACGTCGCAGGTCGCATCGCTCAA
ACTTTAATGAACTTAGCTAAACAGCCTGAAGCAATGACGCATCCTGATGGTATGCAAATCAAAATTACACGCCAAGAAAT
AGGGCAAATGGTGGGTTGTTCACGAGAAACTGTGGGGCGCATTATTAAGATGTTGGAGGATCAGAATCTTATCCACGCTC
ATGGAAAAACAATCGTTGTATATGGCGCAAGATAA

Domains

Predicted by InterproScan.

Cyclic nucleotide-binding domain (cNMP_binding)

(36-124)

Crp-like helix-turn-helix domain (HTH_Crp_2)

(156-220)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q4QLV0

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  crp Haemophilus influenzae Rd KW20

100

100

1
  crp Vibrio cholerae strain A1552

75.49

91.071

0.687
  crp Acinetobacter baumannii D1279779

48.705

86.161

0.42

Multiple sequence alignment