Detailed information    

insolico Bioinformatically predicted

Overview

Name   crp   Type   Regulator
Locus tag   NTHIC486_RS00085 Genome accession   NZ_CP007471
Coordinates   15427..16101 (-) Length   224 a.a.
NCBI ID   WP_005647998.1    Uniprot ID   Q4QLV0
Organism   Haemophilus influenzae strain C486     
Function   promote expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 10427..21101
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  NTHIC486_RS00065 (NTHIC486_00012) - 12131..12481 (+) 351 WP_005686227.1 HIT domain-containing protein -
  NTHIC486_RS00070 (NTHIC486_00013) - 12481..12831 (+) 351 WP_005686225.1 YcfL family protein -
  NTHIC486_RS00075 (NTHIC486_00014) nagZ 12835..13887 (+) 1053 WP_005686223.1 beta-N-acetylhexosaminidase -
  NTHIC486_RS00080 (NTHIC486_00015) rlmC 13884..15062 (+) 1179 WP_005686221.1 23S rRNA (uracil(747)-C(5))-methyltransferase RlmC -
  NTHIC486_RS00085 (NTHIC486_00016) crp 15427..16101 (-) 675 WP_005647998.1 cAMP-activated global transcriptional regulator CRP Regulator
  NTHIC486_RS00090 (NTHIC486_00017) - 16086..16337 (-) 252 WP_005647999.1 YheU family protein -
  NTHIC486_RS00095 (NTHIC486_00018) slmA 16359..17015 (-) 657 WP_005648000.1 nucleoid occlusion factor SlmA -
  NTHIC486_RS00100 (NTHIC486_00019) dut 17019..17474 (-) 456 WP_005631431.1 dUTP diphosphatase -
  NTHIC486_RS00105 (NTHIC486_00020) coaBC 17522..18724 (-) 1203 WP_005686217.1 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase CoaBC -
  NTHIC486_RS00110 (NTHIC486_00021) radC 18888..19553 (+) 666 WP_032821549.1 RadC family protein -
  NTHIC486_RS00115 (NTHIC486_00022) rpmB 19767..20003 (+) 237 WP_005542826.1 50S ribosomal protein L28 -
  NTHIC486_RS00120 (NTHIC486_00023) rpmG 20015..20185 (+) 171 WP_005613503.1 50S ribosomal protein L33 -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25151.85 Da        Isoelectric Point: 6.8375

>NTDB_id=119720 NTHIC486_RS00085 WP_005647998.1 15427..16101(-) (crp) [Haemophilus influenzae strain C486]
MSNELTEIDEVVTSSQEEATQRDPVLDWFLTHCHLHKYPAKSTLIHAGEDATTLYYVIKGSVMVSSKDDEGKEMILTYLG
AGQFFGEAGLFDEGSKRSAWVKTKTTCEIAEISYKKYRQLIQANPEILMFLTAQLARRLQNTSRQVTNLAFLDVAGRIAQ
TLMNLAKQPEAMTHPDGMQIKITRQEIGQMVGCSRETVGRIIKMLEDQNLIHAHGKTIVVYGAR

Nucleotide


Download         Length: 675 bp        

>NTDB_id=119720 NTHIC486_RS00085 WP_005647998.1 15427..16101(-) (crp) [Haemophilus influenzae strain C486]
ATGTCAAATGAATTAACCGAAATTGATGAAGTTGTAACCTCCTCTCAAGAAGAAGCAACTCAACGAGATCCCGTTTTAGA
TTGGTTTCTTACTCACTGCCATTTGCATAAGTATCCTGCAAAATCAACTTTAATTCATGCTGGGGAAGATGCGACCACGC
TGTATTACGTAATTAAAGGTTCTGTAATGGTATCTTCAAAAGATGATGAAGGCAAAGAGATGATCCTCACTTACTTAGGT
GCAGGACAATTTTTTGGCGAAGCGGGATTATTTGATGAAGGTTCAAAACGATCAGCTTGGGTAAAAACAAAAACAACATG
TGAAATTGCTGAAATTTCCTATAAGAAATATCGCCAGTTGATTCAGGCAAACCCTGAAATCTTAATGTTTCTCACTGCAC
AATTGGCAAGACGTTTGCAAAATACATCACGTCAAGTCACGAATTTGGCATTTTTAGACGTCGCAGGTCGCATCGCTCAA
ACTTTAATGAACTTAGCTAAACAGCCTGAAGCAATGACGCATCCTGATGGTATGCAAATCAAAATTACACGCCAAGAAAT
AGGGCAAATGGTGGGTTGTTCACGAGAAACTGTGGGGCGCATTATTAAGATGTTGGAGGATCAGAATCTTATCCACGCTC
ATGGAAAAACAATCGTTGTATATGGCGCAAGATAA

Domains

Predicted by InterproScan.

Cyclic nucleotide-binding domain (cNMP_binding)

(36-124)

Crp-like helix-turn-helix domain (HTH_Crp_2)

(156-220)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q4QLV0

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  crp Haemophilus influenzae Rd KW20

100

100

1
  crp Vibrio cholerae strain A1552

75.49

91.071

0.687
  crp Acinetobacter baumannii D1279779

48.705

86.161

0.42

Multiple sequence alignment