Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaH   Type   Regulator
Locus tag   ACLV7D_RS07085 Genome accession   NZ_OZ217345
Coordinates   1448001..1449335 (-) Length   444 a.a.
NCBI ID   WP_049511744.1    Uniprot ID   -
Organism   Streptococcus mitis isolate S. mitis F22     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 1443001..1454335
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ACLV7D_RS07070 (SMIF22_13930) - 1443966..1446416 (-) 2451 WP_050971615.1 bifunctional DnaQ family exonuclease/ATP-dependent helicase -
  ACLV7D_RS07075 (SMIF22_13940) - 1446616..1447545 (-) 930 WP_000411189.1 peptidase U32 family protein -
  ACLV7D_RS07080 (SMIF22_13950) - 1447685..1447972 (+) 288 WP_049511743.1 DUF3270 domain-containing protein -
  ACLV7D_RS07085 (SMIF22_13960) ciaH 1448001..1449335 (-) 1335 WP_049511744.1 two-component system sensor histidine kinase CiaH Regulator
  ACLV7D_RS07090 (SMIF22_13970) ciaR 1449325..1449999 (-) 675 WP_000590628.1 two-component system response regulator CiaR Regulator
  ACLV7D_RS07095 (SMIF22_13980) - 1450107..1452653 (-) 2547 WP_218764505.1 M1 family metallopeptidase -
  ACLV7D_RS07100 (SMIF22_13990) - 1452776..1453216 (-) 441 WP_218764504.1 ASCH domain-containing protein -
  ACLV7D_RS07105 (SMIF22_14000) - 1453191..1454060 (-) 870 WP_173250045.1 putative PEP-binding protein -

Sequence

Protein


Download         Length: 444 a.a.        Molecular weight: 50704.37 Da        Isoelectric Point: 8.8716

>NTDB_id=1170379 ACLV7D_RS07085 WP_049511744.1 1448001..1449335(-) (ciaH) [Streptococcus mitis isolate S. mitis F22]
MFSKLKKTWYADDFSYFIRNFGVFTLIFSTMTLIILQVMHSSLYTSVDDKLHGLSENPQAVIQLAVNRATEEIKDLENAA
TDTSKTEVKPNVSSNTEVILFDKNFTQLLSGNRFLGLDKIKLEKKELGHIYQIQVFNSYGQEEIYRMILMETNISSVSTN
IKYAAVLINTSQLEQASQKHEQLIVIVMASFWILSLLASLYLARVSVRPLLESMQKQQSFVENASHELRTPLAVLQNRLE
TLFRKPEATIMDVSESIASSLEEVRNMRFLTTNLLNLARRDDGIKPELAEVPTSFFNTTFTNYEMIASENDRVFRFENRI
HRTIVTDQLLLKQLMTILFDNAVKYTEEDGEIDFLISATDRNLYLLVSDNGVGISTEDKKKIFDRFYRVDKARTRQKGGF
GLGLSLAKQIVDALKGTITVKDNKPKGTIFEVKIAIHTPSKKKK

Nucleotide


Download         Length: 1335 bp        

>NTDB_id=1170379 ACLV7D_RS07085 WP_049511744.1 1448001..1449335(-) (ciaH) [Streptococcus mitis isolate S. mitis F22]
ATGTTCAGTAAACTAAAAAAAACATGGTATGCGGATGACTTTAGTTATTTTATCCGCAACTTTGGTGTCTTCACTCTGAT
TTTCTCCACCATGACCTTGATTATTTTACAAGTCATGCATTCGAGTCTCTATACTTCGGTGGATGATAAGCTTCATGGAC
TGAGTGAAAATCCTCAGGCAGTTATTCAGCTTGCGGTAAATAGGGCGACAGAAGAGATTAAAGATTTAGAGAATGCCGCT
ACAGATACTAGCAAGACTGAGGTGAAACCCAATGTCAGCTCCAATACGGAGGTTATTCTTTTTGATAAGAATTTTACCCA
GCTCCTTTCTGGAAATCGATTTTTGGGCTTGGATAAGATTAAGTTAGAAAAGAAAGAACTAGGACATATCTACCAGATTC
AAGTTTTTAATAGCTATGGACAAGAAGAAATCTATCGCATGATCTTGATGGAAACGAATATCAGTTCGGTTTCAACCAAT
ATCAAGTATGCTGCTGTCTTGATTAATACCAGTCAGTTGGAGCAGGCCAGTCAAAAGCATGAGCAATTGATTGTGATTGT
GATGGCAAGTTTCTGGATTTTGTCTTTACTTGCCAGTCTCTATCTAGCTAGAGTCAGTGTTCGGCCCCTGCTTGAGAGTA
TGCAGAAGCAACAGTCCTTTGTGGAAAATGCCAGTCATGAGTTACGAACTCCACTTGCAGTTTTGCAAAATCGCTTAGAG
ACCCTTTTCCGTAAGCCAGAAGCAACCATTATGGATGTGAGTGAAAGCATTGCATCGAGTTTGGAAGAAGTTCGAAATAT
GCGGTTTTTGACGACGAACTTGTTGAATTTAGCTCGGAGAGATGATGGGATTAAGCCGGAACTTGCAGAAGTTCCAACCA
GTTTTTTCAATACGACTTTCACAAACTATGAGATGATTGCTTCGGAAAATGATCGTGTCTTCCGTTTTGAAAATCGCATC
CATCGAACGATTGTCACAGACCAGCTTCTCTTGAAGCAGTTGATGACGATTCTCTTCGATAATGCCGTCAAGTATACTGA
AGAGGATGGTGAAATTGATTTTCTTATCTCAGCGACCGATCGCAATCTGTATTTACTGGTTTCTGATAATGGAGTCGGTA
TTTCGACAGAAGATAAGAAGAAAATTTTTGACCGCTTTTATCGAGTTGATAAGGCTAGAACGCGCCAAAAAGGTGGTTTT
GGTTTAGGATTATCCCTAGCCAAGCAAATTGTAGATGCTTTAAAAGGAACCATTACTGTCAAAGATAATAAACCCAAGGG
TACAATCTTTGAAGTGAAGATTGCCATCCACACACCGTCTAAAAAGAAAAAATAA

Domains

Predicted by InterproScan.

His Kinase A (phospho-acceptor) domain (HisKA)

(217-283)

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(327-434)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaH Streptococcus pneumoniae Rx1

96.847

100

0.968
  ciaH Streptococcus pneumoniae D39

96.847

100

0.968
  ciaH Streptococcus pneumoniae R6

96.847

100

0.968
  ciaH Streptococcus pneumoniae TIGR4

96.847

100

0.968
  ciaH Streptococcus mutans UA159

55.632

97.973

0.545

Multiple sequence alignment