Detailed information NTG1170138

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: ACLV65_RS08020
• Genome accession: NZ_OZ217342
• Coordinates: 1613817..1614554 (-)
• Length: 245 a.a.
• NCBI ID: WP_301352169.1
• Uniprot ID: -
• Organism: Streptococcus mitis isolate S. mitis B22
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
Genomic island	1611632..1620224	1613817..1614554	within	0

Gene organization within MGE regions

Location: 1611632..1620224

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACLV65_RS08010 (SMIB22_15750)	-	1611632..1611751 (-)	120	WP_001829206.1	PncF family bacteriocin immunity protein	-
ACLV65_RS08015 (SMIB22_15770)	-	1612454..1613803 (-)	1350	WP_411864994.1	sensor histidine kinase	-
ACLV65_RS08020 (SMIB22_15780)	comE/blpR	1613817..1614554 (-)	738	WP_301352169.1	response regulator transcription factor	Regulator
ACLV65_RS08025 (SMIB22_15790)	-	1614559..1614897 (-)	339	WP_000682127.1	LytTR family DNA-binding domain-containing protein	-
ACLV65_RS08030 (SMIB22_15800)	-	1615174..1615503 (+)	330	WP_411864995.1	helicase BlpT	-
ACLV65_RS08035 (SMIB22_15810)	-	1615566..1616615 (-)	1050	WP_411864996.1	ABC transporter permease	-
ACLV65_RS08040 (SMIB22_15820)	pptA	1616612..1617343 (-)	732	WP_411864997.1	ABC transporter ATP-binding protein	Regulator
ACLV65_RS08045 (SMIB22_15830)	-	1617411..1617821 (+)	411	WP_411864998.1	HIT family protein	-
ACLV65_RS08050 (SMIB22_15840)	-	1617831..1618118 (+)	288	WP_411864999.1	hypothetical protein	-
ACLV65_RS08055 (SMIB22_15850)	dnaJ	1618408..1619544 (-)	1137	WP_411865000.1	molecular chaperone DnaJ	-
ACLV65_RS08060 (SMIB22_15860)	-	1619823..1620224 (-)	402	WP_218774467.1	tRNA (guanine-N7)-methyltransferase	-

Sequence

Protein

• Length: 245 a.a.
• Molecular weight: 28720.96 Da
• Isoelectric Point: 6.5886

>NTDB_id=1170138 ACLV65_RS08020 WP_301352169.1 1613817..1614554(-) (comE/blpR) [Streptococcus mitis isolate S. mitis B22]
MRIFVLEDDFSQQTRIETTIEKLLKEHHITPSSFEVFGKPAQLLAEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIRDRD
PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSAEEFESRIETALLYANGQDSKSLAEDCFYFKSKFAQFQYPFKEVYY
LETSPRAHRVILYTKTDRLEFTASLEEILKQEPRLLQCHRSFLINPANVIHLDKKEKLLFFPNGGSCLIARYKVREVSEA
INKLH

Nucleotide

• Length: 738 bp

>NTDB_id=1170138 ACLV65_RS08020 WP_301352169.1 1613817..1614554(-) (comE/blpR) [Streptococcus mitis isolate S. mitis B22]
ATGAGAATATTTGTTTTAGAAGATGATTTTTCCCAACAGACTAGAATTGAAACGACGATTGAGAAACTTTTGAAGGAACA
TCATATCACTCCGAGTTCTTTTGAAGTTTTTGGTAAGCCAGCTCAACTGCTGGCAGAGGTGCATGAGAAGGGAGCCCATC
AGCTATTCTTTTTGGACATTGAGATTCGAAATGAGGAGATGAAGGGTCTGGAAGTGGCTAGAAAGATTCGGGATCGGGAT
CCTTATGCCCTCATCGTCTTTGTGACGACTCACTCAGAGTTTATGCCCCTGTCTTTTCGCTACCAAGTGTCTGCTTTGGA
CTACATTGATAAGGCCTTGTCAGCAGAGGAGTTTGAATCTCGGATCGAGACAGCCCTCCTCTATGCCAATGGTCAAGACA
GTAAAAGTCTGGCGGAAGATTGCTTTTACTTTAAATCAAAATTTGCCCAATTCCAGTATCCTTTTAAAGAGGTTTATTAT
CTTGAAACATCGCCCAGAGCCCATCGTGTTATTCTCTATACCAAGACAGACAGACTGGAATTTACAGCGAGTTTAGAGGA
GATTCTCAAGCAGGAGCCTCGTCTCCTGCAGTGTCATCGCTCTTTTCTCATCAATCCAGCCAATGTGATACATTTGGATA
AGAAAGAAAAACTGCTTTTCTTTCCCAATGGTGGAAGTTGTCTAATCGCCCGTTATAAGGTCAGGGAAGTGTCTGAGGCC
ATCAATAAATTACACTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (3-122)

• LytTr DNA-binding domain (LytTR) (151-241)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	54.251	100	0.547
comE/comE1	Streptococcus equinus JB1	43.038	96.735	0.416
comE/comE2	Streptococcus equinus JB1	36.777	98.776	0.363