Detailed information NTG1152134

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: MMH06_RS10765
• Genome accession: NZ_OV904788
• Coordinates: 2096211..2096948 (-)
• Length: 245 a.a.
• NCBI ID: WP_001219126.1
• Uniprot ID: A7XHJ0
• Organism: Streptococcus pneumoniae strain RMV7 isolate RMV7domi
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 2091211..2101948

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
MMH06_RS10750	-	2092608..2092823 (+)	216	WP_001814708.1	S24 family peptidase	-
MMH06_RS11080	-	2092985..2093098 (+)	114	Protein_2096	site-specific integrase	-
MMH06_RS10755 (IONPJBJN_02142)	-	2093272..2094618 (+)	1347	WP_001821303.1	IS1380-like element ISSpn5 family transposase	-
MMH06_RS10760 (IONPJBJN_02143)	-	2094858..2096198 (-)	1341	WP_000275284.1	sensor histidine kinase	-
MMH06_RS10765 (IONPJBJN_02144)	comE/blpR	2096211..2096948 (-)	738	WP_001219126.1	response regulator transcription factor	Regulator
MMH06_RS10770 (IONPJBJN_02145)	-	2096953..2097291 (-)	339	WP_000682122.1	LytTR family DNA-binding domain-containing protein	-
MMH06_RS10775 (IONPJBJN_02146)	-	2097567..2097896 (+)	330	WP_000132575.1	hypothetical protein	-
MMH06_RS10780 (IONPJBJN_02147)	-	2098064..2099113 (-)	1050	WP_000653752.1	ABC transporter permease	-
MMH06_RS10785 (IONPJBJN_02148)	pptA	2099110..2099841 (-)	732	WP_000889923.1	ABC transporter ATP-binding protein	Regulator
MMH06_RS10790 (IONPJBJN_02149)	-	2099909..2100319 (+)	411	WP_001278301.1	HIT family protein	-
MMH06_RS10795 (IONPJBJN_02150)	-	2100329..2100616 (+)	288	WP_000777760.1	hypothetical protein	-
MMH06_RS10800	-	2100778..2100972 (+)	195	WP_001808905.1	hypothetical protein	-

Sequence

Protein

• Length: 245 a.a.
• Molecular weight: 28752.92 Da
• Isoelectric Point: 6.2357

>NTDB_id=1152134 MMH06_RS10765 WP_001219126.1 2096211..2096948(-) (comE/blpR) [Streptococcus pneumoniae strain RMV7 isolate RMV7domi]
MRIFVLEDDFSQQTRIETTIEKLLKAHHIIPSSFEVFGKPDQLLAEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIREQD
PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSAEEFESRIETALLYANSQDSKSLAEDCFYFKSKFAQFQYPFKEVYY
LETSPRPHRVILYTKTDRLEFTASLEEVFKQEPRLLQCHRSFLINPANVVHLDKKEKLLFFPNGGSCLIARYKVREVSEA
INNLH

Nucleotide

• Length: 738 bp

>NTDB_id=1152134 MMH06_RS10765 WP_001219126.1 2096211..2096948(-) (comE/blpR) [Streptococcus pneumoniae strain RMV7 isolate RMV7domi]
ATGAGAATATTTGTTTTAGAAGATGATTTTTCCCAACAGACTAGAATTGAAACGACGATTGAGAAACTTTTGAAAGCACA
TCATATCATTCCTAGCTCTTTTGAGGTATTTGGCAAGCCGGACCAACTGCTGGCAGAGGTGCATGAGAAGGGGGCCCATC
AGCTATTCTTTTTGGATATTGAGATTCGAAATGAAGAGATGAAGGGACTGGAAGTGGCTAGAAAGATTCGGGAACAAGAC
CCTTATGCCCTAATCGTCTTTGTGACGACTCACTCGGAGTTTATGCCTCTGTCCTTTCGCTACCAAGTGTCAGCTTTGGA
CTACATTGATAAGGCCCTTTCGGCAGAGGAGTTTGAATCTCGTATCGAGACAGCCCTCCTCTATGCCAATAGTCAAGATA
GTAAAAGTCTGGCGGAAGATTGCTTTTACTTTAAATCAAAATTTGCCCAATTCCAATATCCTTTCAAAGAGGTTTACTAT
CTCGAAACATCCCCAAGACCCCATCGTGTTATTCTCTATACCAAGACGGACAGGCTAGAATTTACGGCGAGTTTAGAGGA
GGTTTTTAAGCAGGAACCCCGTCTCTTGCAGTGCCATCGCTCTTTTCTCATCAATCCTGCAAATGTGGTGCATTTGGATA
AGAAAGAAAAACTCCTTTTCTTTCCCAATGGTGGAAGCTGTCTGATCGCGCGTTATAAGGTCAGGGAAGTGTCTGAGGCT
ATTAATAACTTACACTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (3-122)

• LytTr DNA-binding domain (LytTR) (151-241)

3D structure

• AlphaFold DB: A7XHJ0

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	53.909	99.184	0.535
comE/comE1	Streptococcus equinus JB1	43.882	96.735	0.424
comE/comE2	Streptococcus equinus JB1	38.843	98.776	0.384