Detailed information NTG1147650

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: CKV88_RS08855
• Genome accession: NZ_LT906460
• Coordinates: 1891507..1892550 (-)
• Length: 347 a.a.
• NCBI ID: WP_002464446.1
• Uniprot ID: G5JJU1
• Organism: Staphylococcus simiae strain NCTC13838
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1886507..1897550

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
CKV88_RS08825 (SAMEA4384339_01799)	-	1886814..1888058 (-)	1245	WP_002464452.1	aminopeptidase	-
CKV88_RS08830 (SAMEA4384339_01800)	-	1888073..1888273 (-)	201	WP_088177495.1	DUF1128 family protein	-
CKV88_RS08835 (SAMEA4384339_01801)	-	1888420..1888884 (+)	465	WP_002464450.1	low molecular weight protein-tyrosine-phosphatase	-
CKV88_RS08840 (SAMEA4384339_01802)	-	1888891..1889166 (+)	276	WP_002464449.1	hypothetical protein	-
CKV88_RS08845 (SAMEA4384339_01803)	-	1889462..1890679 (+)	1218	WP_002464448.1	YihY/virulence factor BrkB family protein	-
CKV88_RS08850 (SAMEA4384339_01804)	vraR	1890888..1891517 (-)	630	WP_002464447.1	two-component system response regulator VraR	Regulator
CKV88_RS08855 (SAMEA4384339_01805)	vraS	1891507..1892550 (-)	1044	WP_002464446.1	sensor histidine kinase	Regulator
CKV88_RS08860 (SAMEA4384339_01806)	liaF	1892547..1893248 (-)	702	WP_002464445.1	cell wall-active antibiotics response protein LiaF	-
CKV88_RS08865 (SAMEA4384339_01807)	-	1893263..1893649 (-)	387	WP_002464444.1	hypothetical protein	-
CKV88_RS08870 (SAMEA4384339_01808)	map	1893886..1894641 (-)	756	WP_002464443.1	type I methionyl aminopeptidase	-
CKV88_RS08875 (SAMEA4384339_01809)	-	1894818..1895804 (+)	987	WP_002464442.1	aromatic acid exporter family protein	-
CKV88_RS08880 (SAMEA4384339_01810)	-	1896149..1896871 (-)	723	WP_002464101.1	type 1 glutamine amidotransferase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40117.54 Da
• Isoelectric Point: 5.2947

>NTDB_id=1147650 CKV88_RS08855 WP_002464446.1 1891507..1892550(-) (vraS) [Staphylococcus simiae strain NCTC13838]
MNHYIRTIGSMLILVYSMLAAFFFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIIFLCIIVGSILAYKINQQNEWIKT
QIERSIEGETVGINDQNIELYSETIELYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETTLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVVDLQKKVPMKVVHEI
QEFKVPKGIEDHLFRITQEAISNTLRHSDGTKVTVELFNKEDYLLLRIQDNGKGFDMNDEVKQSYGLKNMEERALEIGAT
FHIISMPDAGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=1147650 CKV88_RS08855 WP_002464446.1 1891507..1892550(-) (vraS) [Staphylococcus simiae strain NCTC13838]
ATGAATCACTATATAAGAACGATAGGTTCTATGTTGATTTTAGTATATAGTATGTTAGCAGCATTTTTCTTTATTGATAA
AGTGTTTGTTAATATCATTTATTTTCAAGGGATGTTTTATACCCAAATTTTTGGTATTCCAGTATTTTTATTTTTAAATT
TAATTATTATTTTCTTATGTATTATTGTAGGATCTATTTTAGCTTATAAGATTAATCAACAAAATGAATGGATTAAGACT
CAAATTGAACGCTCTATAGAAGGTGAAACAGTTGGTATTAATGACCAAAATATTGAATTATATAGTGAAACAATTGAGTT
ATATCATACGTTAGTCCCTTTAAATCAAGAATTACATAAATTAAGATTAAAGACACAAAATTTAACTAACGAGAATTATA
ATATTAATGATGTCAAAGTTAAAAAAATAATCGAAGATGAACGACAACGCTTAGCTAGAGAATTACATGACTCGGTCAGT
CAGCAATTATTCGCTGCGAGTATGATGCTTTCTGCAATTAAGGAAACAACTTTAGAGCCACCTTTAGATCAACAAATTCC
TATTTTAGAAAAAATGGTGCAAGATTCGCAATTGGAAATGCGAGCACTATTATTACATTTGAGACCTCTAGGCCTAAAAG
ATAAGTCGTTAGGTGAAGGTATTAAAGACTTAGTTGTAGATTTACAGAAGAAAGTACCAATGAAAGTTGTCCATGAAATT
CAAGAGTTCAAAGTACCAAAAGGAATTGAAGATCATCTATTTAGAATTACACAAGAAGCAATTTCTAATACACTTAGACA
TTCCGATGGTACTAAAGTGACTGTCGAATTATTTAATAAAGAAGATTATCTGTTATTAAGAATTCAAGATAACGGTAAAG
GCTTCGATATGAACGATGAAGTAAAACAAAGTTATGGCTTGAAGAACATGGAAGAAAGAGCATTAGAAATTGGTGCGACA
TTCCATATTATTTCAATGCCGGATGCAGGAACGCGTATAGAGGTAAAAGCACCTCTTAATAAGGAGGATTCATATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase (HisKA_3) (147-210)

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

3D structure

• AlphaFold DB: G5JJU1

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	93.084	100	0.931