Detailed information NTG1143868

Bioinformatically predicted

Overview

• Name: agrA
• Type: Regulator
• Locus tag: BN6763_RS09000
• Genome accession: NZ_LT571449
• Coordinates: 1768275..1768991 (+)
• Length: 238 a.a.
• NCBI ID: WP_001829999.1
• Uniprot ID: C0LF82
• Organism: Staphylococcus epidermidis isolate BPH0662
• Function: promote expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1763275..1773991

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
BN6763_RS08975	-	1764673..1765458 (+)	786	WP_001830000.1	carbon-nitrogen family hydrolase	-
BN6763_RS08980	hld	1765839..1765916 (-)	78	WP_002494082.1	delta-hemolysin	-
BN6763_RS08985	-	1766234..1766818 (+)	585	WP_001830005.1	accessory gene regulator AgrB	-
BN6763_RS08990	agrD	1766802..1766942 (+)	141	WP_001830021.1	cyclic lactone autoinducer peptide AgrD	-
BN6763_RS08995	agrC	1766969..1768258 (+)	1290	WP_002440376.1	quorum-sensing sensor histidine kinase AgrC	-
BN6763_RS09000	agrA	1768275..1768991 (+)	717	WP_001829999.1	quorum-sensing response regulator AgrA	Regulator
BN6763_RS09005	-	1769059..1770018 (-)	960	WP_063964228.1	carbohydrate kinase family protein	-
BN6763_RS09010	-	1770025..1771497 (-)	1473	WP_002469009.1	sucrose-6-phosphate hydrolase	-
BN6763_RS09020	-	1771757..1772710 (-)	954	WP_063964229.1	LacI family DNA-binding transcriptional regulator	-

Sequence

Protein

• Length: 238 a.a.
• Molecular weight: 27936.97 Da
• Isoelectric Point: 5.6250

>NTDB_id=1143868 BN6763_RS09000 WP_001829999.1 1768275..1768991(+) (agrA) [Staphylococcus epidermidis isolate BPH0662]
MKIFVCEDDQRQREHMVSIIKNYIMIEEKPMELALATNDPYEVLEQSKELNDIGCYFLDIQLEADMNGIKLASEIRKHDP
VGNIIFVTSHSELTYLTFVYKVAAMDFIFKDDPSELKMRIIDCLETAHTRLKLLSKESNVDTIELKRGSNSVYVQYDDIM
FFESSTKSHRLIAHLDNRQIEFYGNLKELAQLDERFFRCHNSFVINRHNIESIDSKERIVYFKNGENCFASVRNVKKI

Nucleotide

• Length: 717 bp

>NTDB_id=1143868 BN6763_RS09000 WP_001829999.1 1768275..1768991(+) (agrA) [Staphylococcus epidermidis isolate BPH0662]
ATGAAAATTTTTGTTTGTGAAGATGACCAAAGACAAAGAGAACATATGGTATCAATCATTAAAAACTACATAATGATTGA
AGAAAAGCCAATGGAGTTAGCCTTAGCAACAAATGATCCTTATGAGGTCTTAGAGCAATCAAAAGAACTTAATGACATTG
GTTGTTACTTCCTTGATATTCAATTAGAAGCTGATATGAACGGTATTAAATTAGCCAGTGAAATTCGTAAACATGATCCT
GTTGGTAATATTATATTTGTAACCAGTCACAGTGAACTGACTTATTTGACGTTTGTTTATAAAGTGGCTGCTATGGATTT
TATTTTTAAGGATGATCCATCTGAATTAAAAATGAGAATCATAGATTGTCTTGAAACAGCACATACACGACTCAAATTAT
TATCAAAAGAAAGTAATGTAGATACGATTGAGTTAAAGCGGGGAAGTAATTCAGTATACGTTCAATATGATGACATTATG
TTTTTTGAATCATCTACGAAATCTCATAGACTCATCGCACATCTTGATAATCGACAAATTGAATTTTATGGAAATTTAAA
GGAATTAGCACAGCTTGATGAACGTTTCTTTAGATGTCATAACAGTTTTGTGATAAACAGGCATAATATTGAATCTATTG
ATTCAAAAGAACGTATTGTTTACTTTAAGAATGGCGAAAATTGTTTCGCTTCAGTACGTAATGTTAAAAAAATATAA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-237)

• Response regulator receiver domain (Response_reg) (3-120)

3D structure

• AlphaFold DB: C0LF82

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
agrA	Staphylococcus aureus N315	87.815	100	0.878
comE/comE2	Streptococcus gordonii strain NCTC7865	35.178	100	0.374
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	35.178	100	0.374