Detailed information NTG1141895

Bioinformatically predicted

Overview

• Name: ciaH
• Type: Regulator
• Locus tag: DQK98_RS03950
• Genome accession: NZ_LS483449
• Coordinates: 748345..749679 (+)
• Length: 444 a.a.
• NCBI ID: WP_000491790.1
• Uniprot ID: Q7B3G0
• Organism: Streptococcus pneumoniae strain 4041STDY6836170
• Function: repress competence development; post-transcriptional repression of CSP production (predicted from homology) Competence regulation

Genomic Context

Location: 743345..754679

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQK98_RS03930	-	743619..744488 (+)	870	WP_001245821.1	putative PEP-binding protein	-
DQK98_RS03935	-	744463..744903 (+)	441	WP_050090206.1	ASCH domain-containing protein	-
DQK98_RS03940	-	745026..747572 (+)	2547	WP_001149118.1	M1 family metallopeptidase	-
DQK98_RS03945	ciaR	747681..748355 (+)	675	WP_000590640.1	two-component system response regulator CiaR	Regulator
DQK98_RS03950	ciaH	748345..749679 (+)	1335	WP_000491790.1	two-component system sensor histidine kinase CiaH	Regulator
DQK98_RS03955	-	749713..750000 (-)	288	WP_001145225.1	DUF3270 domain-containing protein	-
DQK98_RS03960	-	750140..751069 (+)	930	WP_000411850.1	peptidase U32 family protein	-
DQK98_RS03970	-	751269..753719 (+)	2451	WP_050227485.1	bifunctional DnaQ family exonuclease/ATP-dependent helicase	-

Sequence

Protein

• Length: 444 a.a.
• Molecular weight: 50673.39 Da
• Isoelectric Point: 9.1661

>NTDB_id=1141895 DQK98_RS03950 WP_000491790.1 748345..749679(+) (ciaH) [Streptococcus pneumoniae strain 4041STDY6836170]
MFSKLKKTWYADDFSYFIRNFGVFTLIFSTMTLIILQVMHSSLYTSVDDKLHGLSENPQAVIQLAINRATEEIKDLENAR
ADASKVEIKPNVSSNTEVILFDKDFTQLLSGNRFLGLDKIKLEKKELGHIYQIQVFNSYGQEEIYRVILMETNISSVSTN
IKYAAVLINTSQLEQASQKHEQLIVVVMASFWILSLLASLYLARVSVRPLLESMQKQQSFVENASHELRTPLAVLQNRLE
TLFRKPEATIMDVSESIASSLEEVRNMRFLTTSLLNLARRDDGIKPELAEVPTSFFNTTFTNYEMIASENNRVFRFENRI
HRTIVTDQLLLKQLMTILFDNAVKYTEEDGEIDFLISATDRNLYLLVSDNGIGISTEDKKKIFDRFYRVDKARTRQKGGF
GLGLSLAKQIVDALKGTVTVKDNKPKGTIFEVKIAIQTPSKKKK

Nucleotide

• Length: 1335 bp

>NTDB_id=1141895 DQK98_RS03950 WP_000491790.1 748345..749679(+) (ciaH) [Streptococcus pneumoniae strain 4041STDY6836170]
ATGTTCAGTAAACTTAAAAAAACATGGTATGCGGATGACTTTAGTTATTTTATCCGCAACTTCGGTGTCTTCACCCTGAT
TTTTTCTACAATGACTCTGATTATTTTACAAGTCATGCATTCGAGTCTTTATACTTCGGTGGACGATAAGCTTCATGGAC
TGAGTGAAAATCCTCAAGCAGTTATTCAGCTGGCTATAAATAGGGCAACAGAAGAGATTAAAGATTTAGAAAATGCTAGG
GCGGACGCTAGTAAAGTAGAAATAAAACCTAATGTCAGTTCCAATACGGAAGTCATTCTCTTTGATAAGGACTTTACTCA
ACTTCTTTCTGGAAATCGATTTTTGGGCTTGGATAAGATTAAGTTAGAAAAGAAAGAACTAGGACATATCTACCAGATTC
AGGTTTTTAATAGCTATGGGCAGGAAGAAATCTATCGTGTGATTTTGATGGAGACCAATATTAGTTCGGTTTCAACCAAT
ATCAAGTATGCTGCTGTCTTGATTAATACCAGTCAGTTGGAGCAGGCTAGTCAAAAGCATGAGCAATTGATTGTGGTCGT
GATGGCTAGTTTCTGGATTTTGTCTTTACTTGCCAGTCTCTATCTAGCTAGGGTCAGTGTTAGGCCCCTGCTTGAGAGTA
TGCAGAAGCAACAGTCTTTTGTGGAAAATGCCAGTCATGAGTTACGAACTCCACTCGCAGTTTTGCAAAATCGCTTAGAG
ACCCTTTTTCGTAAGCCAGAAGCTACCATTATGGATGTGAGTGAAAGCATTGCATCGAGTTTGGAAGAAGTCCGAAATAT
GCGTTTTTTAACGACAAGCTTGCTGAACTTAGCTCGGAGAGATGATGGGATTAAGCCAGAGCTTGCAGAAGTTCCAACTA
GCTTTTTTAATACAACTTTCACAAACTATGAGATGATTGCTTCGGAAAATAATCGTGTCTTCCGTTTTGAAAATCGTATC
CATCGAACAATTGTCACAGATCAGCTTCTTCTGAAACAACTGATGACCATTCTTTTCGATAATGCCGTCAAGTATACTGA
GGAGGATGGTGAAATTGATTTTCTTATCTCGGCGACCGATCGCAATCTTTATTTACTTGTTTCTGATAATGGAATCGGTA
TTTCGACAGAAGATAAAAAGAAAATTTTTGACCGTTTTTATCGAGTAGACAAGGCTAGAACCCGGCAAAAAGGTGGTTTT
GGTTTAGGATTATCCCTAGCCAAGCAAATTGTAGATGCTCTAAAAGGAACTGTTACTGTCAAAGATAATAAACCCAAGGG
AACAATCTTTGAAGTGAAGATTGCCATTCAGACACCATCTAAAAAGAAAAAATAA

Domains

Predicted by InterproScan.

• His Kinase A (phospho-acceptor) domain (HisKA) (217-283)

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (327-434)

3D structure

• AlphaFold DB: Q7B3G0

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaH	Streptococcus pneumoniae Rx1	100	100	1
ciaH	Streptococcus pneumoniae D39	100	100	1
ciaH	Streptococcus pneumoniae R6	100	100	1
ciaH	Streptococcus pneumoniae TIGR4	100	100	1
ciaH	Streptococcus mutans UA159	55.632	97.973	0.545