Detailed information NTG1141154

Bioinformatically predicted

Overview

• Name: vicK
• Type: Regulator
• Locus tag: DQN36_RS06930
• Genome accession: NZ_LS483425
• Coordinates: 1387364..1388716 (-)
• Length: 450 a.a.
• NCBI ID: WP_002995609.1
• Uniprot ID: A0A4U7GC27
• Organism: Streptococcus pyogenes strain NCTC13737
• Function: repress comCDE expression; repress comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 1382364..1393716

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQN36_RS06920 (NCTC13737_01370)	rnc	1385416..1386108 (-)	693	WP_002990670.1	ribonuclease III	-
DQN36_RS06925 (NCTC13737_01371)	vicX	1386551..1387360 (-)	810	WP_002985641.1	MBL fold metallo-hydrolase	Regulator
DQN36_RS06930 (NCTC13737_01372)	vicK	1387364..1388716 (-)	1353	WP_002995609.1	cell wall metabolism sensor histidine kinase VicK	Regulator
DQN36_RS06935 (NCTC13737_01373)	vicR	1388709..1389419 (-)	711	WP_002985645.1	response regulator YycF	Regulator
DQN36_RS06940 (NCTC13737_01374)	-	1389581..1390615 (-)	1035	WP_162472284.1	DUF3114 domain-containing protein	-
DQN36_RS06945 (NCTC13737_01375)	-	1390671..1391918 (-)	1248	WP_010921989.1	AMP-binding protein	-
DQN36_RS06950 (NCTC13737_01376)	-	1391875..1393023 (-)	1149	WP_111704296.1	acetyl-CoA C-acyltransferase	-

Sequence

Protein

• Length: 450 a.a.
• Molecular weight: 51391.82 Da
• Isoelectric Point: 5.4026

>NTDB_id=1141154 DQN36_RS06930 WP_002995609.1 1387364..1388716(-) (vicK) [Streptococcus pyogenes strain NCTC13737]
MTRDIIGNLSTFELAILILLVFVAFYFIHLAVRDYRNARIIRMMSHKIRDLINGRYTDIIDEKADIELMELSDQLNDLSD
VFRLTHENLAQEKNRLASILAYMSDGVLATDRSGKIIMINETARKQLNLSKEEALKKNITDLLEGDTSYTYRDLVSKTPV
VTVNSRNDMGEFVSLRLRFALNRRESGFISGLVVVLHDTTEQEKEERERRLFVSNVSHELRTPLTSVKSYLEALDEGALK
EDIAPSFIKVSLDETNRMMRMISDLLNLSRIDNQVTQLAVEMTNFTAFITSILNRFDLVKNQHTGTGKVYEIVRDYPITS
VWIEIDNDKMTQVIENILNNAIKYSPDGGKITVRMKTTDTQLIISISDQGLGIPKTDLPLIFDRFYRVDKARSRAQGGTG
LGLAIAKEIIKQHHGFIWAKSDYGKGSTFTIVLPYEKDAAIYEEWEEDVD

Nucleotide

• Length: 1353 bp

>NTDB_id=1141154 DQN36_RS06930 WP_002995609.1 1387364..1388716(-) (vicK) [Streptococcus pyogenes strain NCTC13737]
ATGACTAGAGATATCATTGGAAACTTATCCACATTTGAATTAGCGATCCTTATCTTACTTGTTTTTGTTGCTTTTTACTT
TATCCATCTTGCGGTGCGTGATTACCGAAATGCACGTATTATTCGGATGATGAGCCATAAAATCCGAGACTTGATTAATG
GTCGCTATACTGATATAATCGACGAAAAAGCAGACATTGAGTTAATGGAGCTTTCAGACCAGTTAAATGACCTGTCAGAT
GTTTTTCGCTTGACGCATGAAAATCTTGCCCAAGAAAAAAATCGCTTGGCAAGTATTTTGGCTTATATGTCAGATGGTGT
ACTTGCTACAGACCGGTCTGGTAAAATCATCATGATTAACGAGACAGCTCGCAAGCAATTAAATTTAAGTAAAGAAGAGG
CACTAAAGAAAAACATTACAGATTTGTTAGAAGGTGATACTTCATATACCTACCGTGATTTGGTATCCAAAACACCAGTG
GTAACTGTTAATAGCCGAAATGATATGGGTGAGTTTGTCTCATTACGCTTGCGCTTTGCGTTGAATAGGAGAGAGAGTGG
TTTTATTTCGGGCTTGGTTGTGGTGCTCCATGACACCACAGAACAGGAAAAAGAAGAACGTGAACGCCGTCTTTTTGTCT
CTAATGTAAGTCATGAATTAAGGACCCCTTTAACTTCGGTTAAATCCTATTTGGAGGCTCTTGATGAAGGTGCACTTAAA
GAAGATATTGCTCCAAGTTTCATAAAAGTTTCTCTTGATGAAACTAATCGGATGATGCGTATGATTTCAGATCTTTTAAA
CCTGTCTCGGATTGATAATCAAGTAACCCAATTAGCAGTAGAGATGACTAATTTTACTGCTTTTATAACTTCTATTTTAA
ACAGATTTGATTTGGTTAAAAATCAGCATACAGGTACAGGAAAAGTCTATGAAATTGTAAGAGATTACCCTATTACCTCT
GTCTGGATTGAAATTGATAATGATAAAATGACACAGGTTATCGAGAATATTTTGAACAATGCCATTAAGTATTCTCCAGA
TGGTGGAAAAATTACAGTCCGTATGAAAACAACAGATACCCAATTAATTATTTCCATTTCAGACCAAGGACTAGGTATCC
CTAAAACAGATTTGCCTCTTATTTTTGATCGGTTCTATCGTGTAGACAAGGCAAGAAGTCGTGCCCAAGGAGGGACCGGT
CTAGGCCTTGCCATTGCTAAAGAAATCATCAAGCAGCACCATGGCTTTATCTGGGCTAAGAGTGACTATGGTAAAGGATC
GACCTTTACTATTGTCTTGCCTTATGAAAAAGATGCAGCCATCTATGAAGAATGGGAGGAAGATGTAGACTAA

Domains

Predicted by InterproScan.

• PAS fold (PAS) (95-162)

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (326-436)

• His Kinase A (phospho-acceptor) domain (HisKA) (209-273)

3D structure

• AlphaFold DB: A0A4U7GC27

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vicK	Streptococcus mutans UA159	72.947	92	0.671
micB	Streptococcus pneumoniae Cp1015	67.765	94.444	0.64