Detailed information NTG1140812

Bioinformatically predicted

Overview

• Name: vicK
• Type: Regulator
• Locus tag: DQN57_RS02375
• Genome accession: NZ_LS483415
• Coordinates: 429911..431263 (+)
• Length: 450 a.a.
• NCBI ID: WP_111705500.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain NCTC8304
• Function: repress comCDE expression; repress comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 424911..436263

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQN57_RS02350 (NCTC8304_00462)	-	425066..425635 (+)	570	WP_011017490.1	hypothetical protein	-
DQN57_RS02355 (NCTC8304_00463)	-	425604..426752 (+)	1149	WP_002985651.1	acetyl-CoA C-acyltransferase	-
DQN57_RS02360 (NCTC8304_00464)	-	426709..427956 (+)	1248	WP_038433654.1	AMP-binding protein	-
DQN57_RS02365 (NCTC8304_00465)	-	428012..429046 (+)	1035	WP_172453934.1	DUF3114 domain-containing protein	-
DQN57_RS02370 (NCTC8304_00466)	vicR	429208..429918 (+)	711	WP_002985645.1	response regulator YycF	Regulator
DQN57_RS02375 (NCTC8304_00467)	vicK	429911..431263 (+)	1353	WP_111705500.1	cell wall metabolism sensor histidine kinase VicK	Regulator
DQN57_RS02380 (NCTC8304_00468)	vicX	431267..432076 (+)	810	WP_002985641.1	MBL fold metallo-hydrolase	Regulator
DQN57_RS02385 (NCTC8304_00469)	rnc	432508..433200 (+)	693	WP_002990670.1	ribonuclease III	-

Sequence

Protein

• Length: 450 a.a.
• Molecular weight: 51421.84 Da
• Isoelectric Point: 5.4026

>NTDB_id=1140812 DQN57_RS02375 WP_111705500.1 429911..431263(+) (vicK) [Streptococcus pyogenes strain NCTC8304]
MTRDIIGNLSTFELAILILLVFVAFYFIHLAVRDYRNARIIRMMSHKIRDLINGRYTDIIDEKADIELMELSDQLNDLSD
VFRLTHENLAQEKNRLASILAYMSDGVLATDRSGKIIMINETARKQLNLSKEEALKKNITDLLEGDTSYTYRDLVSKTPV
VTVNSRNDMGEFVSLRLRFALNRRESGFISGLVVVLHDTTEQEKEERERRLFVSNVSHELRTPLTSVKSYLEALDEGALK
EDIAPSFIKVSLDETNRMMRMISDLLNLSRIDNQVTQLAVEMTNFTAFITSILNRFDLVKNQHTGTGKVYEIVRDYPITS
VWLEIDNDKMTQVIENILNNAIKYSPDGGKITVRMKTTDTQLIISISDQGLGIPKTDLPLIFDRFYRVDKARSRAQGGTG
LGLAIAKEIIKQHHGFIWAKSDYGKGSTFTIVLPYEKDTAIYEEWEEDVD

Nucleotide

• Length: 1353 bp

>NTDB_id=1140812 DQN57_RS02375 WP_111705500.1 429911..431263(+) (vicK) [Streptococcus pyogenes strain NCTC8304]
ATGACTAGAGATATCATTGGAAACTTATCCACATTTGAATTAGCGATCCTTATCTTACTTGTTTTTGTTGCTTTTTACTT
TATCCATCTTGCGGTGCGTGATTACCGAAATGCACGTATTATTCGGATGATGAGCCATAAAATCCGAGACTTGATTAATG
GTCGCTATACTGATATAATCGACGAAAAAGCAGACATTGAGTTAATGGAGCTTTCAGACCAGTTAAATGACCTGTCAGAT
GTTTTTCGCTTGACGCATGAAAATCTTGCCCAAGAAAAAAATCGCTTGGCAAGTATTTTGGCTTATATGTCAGATGGTGT
ACTTGCTACAGACCGGTCTGGTAAAATCATCATGATTAACGAGACAGCTCGCAAGCAATTAAATTTAAGTAAAGAAGAGG
CACTAAAGAAAAACATTACAGATTTGTTAGAAGGTGATACTTCATATACCTATCGTGATTTGGTATCCAAAACACCAGTG
GTAACTGTTAATAGCCGAAATGATATGGGTGAGTTTGTCTCATTACGCTTGCGCTTTGCGTTGAATAGGAGAGAGAGTGG
TTTTATTTCGGGCTTGGTTGTGGTGCTCCATGACACCACAGAACAAGAAAAAGAAGAACGTGAACGCCGTCTTTTTGTCT
CTAATGTAAGTCATGAATTAAGGACCCCTTTAACTTCGGTTAAATCCTACTTGGAGGCTCTTGATGAAGGTGCACTTAAA
GAAGATATTGCTCCAAGTTTCATAAAAGTTTCTCTTGATGAAACTAATCGGATGATGCGTATGATTTCAGATCTTTTAAA
CCTGTCTCGGATTGATAATCAAGTAACCCAATTAGCAGTAGAGATGACTAATTTTACTGCTTTTATAACTTCTATTTTAA
ACAGATTTGATTTGGTTAAAAATCAGCATACAGGTACAGGAAAAGTCTATGAAATTGTAAGAGATTACCCTATTACCTCT
GTCTGGCTTGAAATTGATAATGATAAAATGACACAGGTTATCGAGAATATTTTGAACAATGCCATTAAGTATTCTCCAGA
TGGTGGAAAAATTACAGTCCGTATGAAAACAACAGATACCCAATTAATTATTTCCATTTCAGACCAAGGACTAGGTATCC
CTAAAACAGATTTGCCTCTTATTTTTGATCGGTTCTATCGTGTAGACAAGGCAAGAAGTCGTGCCCAAGGAGGGACCGGT
CTAGGCCTTGCCATTGCTAAAGAAATCATCAAGCAGCACCATGGCTTTATCTGGGCTAAGAGTGACTATGGTAAAGGATC
GACCTTTACTATTGTCTTGCCTTATGAAAAAGATACAGCCATCTATGAAGAATGGGAGGAAGATGTAGACTAA

Domains

Predicted by InterproScan.

• His Kinase A (phospho-acceptor) domain (HisKA) (209-273)

• PAS fold (PAS) (95-162)

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (326-436)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vicK	Streptococcus mutans UA159	72.705	92	0.669
micB	Streptococcus pneumoniae Cp1015	67.529	94.444	0.638