Detailed information NTG1138171

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: DQL13_RS07585
• Genome accession: NZ_LS483354
• Coordinates: 1609244..1609993 (-)
• Length: 249 a.a.
• NCBI ID: WP_012516119.1
• Uniprot ID: B4U4E3
• Organism: Streptococcus equi subsp. zooepidemicus strain NCTC11606
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
IScluster/Tn	1610291..1616935	1609244..1609993	flank	298

Gene organization within MGE regions

Location: 1609244..1616935

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQL13_RS07585 (NCTC11606_01520)	comE/blpR	1609244..1609993 (-)	750	WP_012516119.1	LytR/AlgR family response regulator transcription factor	Regulator
DQL13_RS07590 (NCTC11606_01521)	-	1610291..1611244 (-)	954	WP_012514856.1	IS30 family transposase	-
DQL13_RS07595 (NCTC11606_01522)	-	1611713..1611916 (-)	204	WP_012516120.1	TmhB bacteriocin enhancer peptide	-
DQL13_RS07600 (NCTC11606_01523)	-	1611933..1612190 (-)	258	WP_012516121.1	Blp family class II bacteriocin	-
DQL13_RS07605 (NCTC11606_01524)	rlmD	1612511..1613878 (-)	1368	WP_111721727.1	23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD	-
DQL13_RS07610 (NCTC11606_01525)	-	1613875..1614843 (-)	969	WP_012516123.1	helix-hairpin-helix domain-containing protein	-
DQL13_RS07615 (NCTC11606_01526)	-	1614964..1615122 (-)	159	WP_228275460.1	DUF4368 domain-containing protein	-
DQL13_RS07620 (NCTC11606_01528)	-	1615593..1616935 (+)	1343	WP_165626751.1	IS3 family transposase	-

Sequence

Protein

• Length: 249 a.a.
• Molecular weight: 29208.64 Da
• Isoelectric Point: 8.4569

>NTDB_id=1138171 DQL13_RS07585 WP_012516119.1 1609244..1609993(-) (comE/blpR) [Streptococcus equi subsp. zooepidemicus strain NCTC11606]
MRVVILEDDMIQQRYLEKLIKELEVKHQLLFQGLDCFGRSHQLLSAIKKNCGQQLFFLDIEIKNEDKKGLEVARQIRQIN
PDAMIVFVTTHSEFMPLAFQYQVSALDYIDKELPQTEFVQRVETALLYAVRQNSETIAESAFYFTSRYAQVQVPFNDILY
IETSSRAHRVNLYTKKERMQFTGTLTDILKQESRFLQCHRSFLINPRNVVRVDKIERVVYFRNGSSCLIARSKMNSVLTT
IENLHRGDN

Nucleotide

• Length: 750 bp

>NTDB_id=1138171 DQL13_RS07585 WP_012516119.1 1609244..1609993(-) (comE/blpR) [Streptococcus equi subsp. zooepidemicus strain NCTC11606]
GTGAGAGTAGTTATTTTAGAAGATGATATGATTCAGCAGAGATATTTAGAAAAGCTCATTAAAGAGCTTGAGGTTAAGCA
CCAGCTATTATTTCAAGGACTTGACTGTTTTGGAAGGTCTCACCAGCTATTAAGTGCTATCAAGAAGAACTGTGGTCAGC
AGCTATTCTTTTTAGATATTGAGATAAAAAATGAGGACAAAAAAGGGCTTGAGGTTGCTAGGCAAATTCGTCAGATAAAT
CCAGATGCGATGATTGTTTTTGTAACGACTCACTCGGAATTTATGCCCTTGGCTTTTCAGTATCAGGTATCTGCTTTGGA
CTATATCGATAAAGAGCTGCCCCAAACTGAGTTTGTTCAACGGGTAGAGACTGCTTTATTATATGCTGTGCGGCAAAATA
GTGAAACGATAGCGGAAAGTGCTTTTTATTTTACATCTCGTTATGCTCAGGTACAGGTGCCTTTTAATGATATCCTGTAT
ATTGAGACATCGTCACGAGCGCATCGTGTCAATTTGTATACAAAAAAGGAGAGAATGCAATTTACAGGGACTTTGACGGA
TATTTTGAAGCAAGAGTCTCGTTTTTTGCAATGTCATCGTTCTTTTTTGATTAATCCTAGGAATGTCGTTAGGGTAGATA
AGATTGAGCGAGTGGTTTATTTTCGAAATGGCTCTAGCTGCTTAATTGCTCGTAGTAAAATGAACAGTGTTTTAACAACA
ATTGAGAACCTACATAGAGGAGATAATTAA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-237)

• Response regulator receiver domain (Response_reg) (3-122)

3D structure

• AlphaFold DB: B4U4E3

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	52.209	100	0.522
comE/comE1	Streptococcus equinus JB1	40.586	95.984	0.39
comE/comE2	Streptococcus equinus JB1	36.29	99.598	0.361