Detailed information NTG1138159

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: DQL13_RS04955
• Genome accession: NZ_LS483354
• Coordinates: 1042803..1043540 (+)
• Length: 245 a.a.
• NCBI ID: WP_012515591.1
• Uniprot ID: B4U2V5
• Organism: Streptococcus equi subsp. zooepidemicus strain NCTC11606
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 1037803..1048540

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQL13_RS04925 (NCTC11606_00983)	-	1038253..1039158 (-)	906	WP_012515585.1	diacylglycerol/lipid kinase family protein	-
DQL13_RS04930 (NCTC11606_00984)	trhA	1039268..1039918 (-)	651	WP_012515586.1	PAQR family membrane homeostasis protein TrhA	-
DQL13_RS04935 (NCTC11606_00985)	-	1039902..1040357 (-)	456	WP_012515587.1	DUF1836 domain-containing protein	-
DQL13_RS04940 (NCTC11606_00986)	-	1040617..1041372 (+)	756	WP_012515588.1	class I SAM-dependent methyltransferase	-
DQL13_RS04945 (NCTC11606_00987)	-	1041400..1041738 (+)	339	WP_012515589.1	cupin domain-containing protein	-
DQL13_RS04950 (NCTC11606_00988)	-	1041740..1042045 (+)	306	WP_012515590.1	hypothetical protein	-
DQL13_RS04955 (NCTC11606_00989)	comE/blpR	1042803..1043540 (+)	738	WP_012515591.1	response regulator transcription factor	Regulator
DQL13_RS04960 (NCTC11606_00990)	-	1043913..1044113 (+)	201	WP_012515592.1	hypothetical protein	-
DQL13_RS04965 (NCTC11606_00991)	-	1044180..1045034 (+)	855	WP_012515593.1	ABC transporter ATP-binding protein	-
DQL13_RS04970 (NCTC11606_00992)	-	1045040..1046203 (+)	1164	WP_111721682.1	ABC transporter permease subunit	-
DQL13_RS04975 (NCTC11606_00993)	-	1046465..1046695 (+)	231	WP_012515596.1	Blp family class II bacteriocin	-
DQL13_RS04985 (NCTC11606_00994)	-	1047488..1048339 (+)	852	WP_012515597.1	thioredoxin family protein	-

Sequence

Protein

• Length: 245 a.a.
• Molecular weight: 28894.28 Da
• Isoelectric Point: 7.8796

>NTDB_id=1138159 DQL13_RS04955 WP_012515591.1 1042803..1043540(+) (comE/blpR) [Streptococcus equi subsp. zooepidemicus strain NCTC11606]
MNIFILEDDLGQQFRLEMKIQEILDKHHWTCDRFEVYGKPYQLLANVTERGRHQLFFLDSQIRNDEKKGLAVAREIRKRD
PYALIVFVTTHSELMPVSFRYQVSALDFIDKELSMKHFSDRIERAIIYAYEEQENVTSEGLFIFVTAKAQVQVPFSSLLF
IETSSTPHKLILHSQNERIEFYGFLSEVLKQDSRLVQCHRSYVINPYNVSFLDRDKRLLYFKNGQSCMVSRLKMKALEAS
IKALH

Nucleotide

• Length: 738 bp

>NTDB_id=1138159 DQL13_RS04955 WP_012515591.1 1042803..1043540(+) (comE/blpR) [Streptococcus equi subsp. zooepidemicus strain NCTC11606]
ATGAATATTTTTATTCTCGAAGATGATCTAGGCCAACAGTTTAGGCTTGAGATGAAGATTCAAGAGATATTGGATAAGCA
TCACTGGACTTGTGATCGTTTTGAAGTTTATGGAAAGCCCTACCAGCTTCTGGCAAATGTTACAGAGAGAGGCAGGCATC
AGCTTTTCTTTCTCGATAGTCAAATTCGAAATGATGAGAAAAAGGGCTTAGCTGTTGCTCGTGAGATCAGAAAGCGTGAC
CCTTATGCCCTCATTGTTTTTGTCACCACACATTCTGAGCTTATGCCAGTTTCTTTTCGTTATCAGGTGTCTGCTCTAGA
TTTTATCGATAAGGAATTGTCAATGAAACATTTCTCAGATAGGATTGAAAGAGCCATTATATATGCTTATGAAGAGCAAG
AAAATGTAACCTCAGAGGGCTTATTTATTTTTGTAACGGCTAAGGCTCAGGTGCAGGTTCCTTTTTCAAGCCTATTGTTC
ATTGAGACCTCTAGTACTCCTCACAAGTTGATTTTGCATTCTCAAAACGAGCGAATAGAATTTTATGGCTTTCTTTCAGA
GGTTCTTAAGCAAGATTCCAGACTAGTCCAATGTCATCGTTCTTATGTTATCAATCCTTACAATGTTTCGTTTCTTGATC
GTGATAAGCGTTTACTCTATTTCAAGAATGGGCAGTCTTGCATGGTTTCAAGACTAAAAATGAAAGCACTTGAGGCGTCT
ATTAAGGCTTTGCATTGA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-240)

• Response regulator receiver domain (Response_reg) (18-122)

3D structure

• AlphaFold DB: B4U2V5

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	53.719	98.776	0.531
comE/comE1	Streptococcus equinus JB1	45.455	98.776	0.449
comE/comE2	Streptococcus equinus JB1	36.885	99.592	0.367