Detailed information NTG1138043

Bioinformatically predicted

Overview

• Name: vicK
• Type: Regulator
• Locus tag: DQL37_RS02455
• Genome accession: NZ_LS483352
• Coordinates: 441314..442666 (+)
• Length: 450 a.a.
• NCBI ID: WP_111685688.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain NCTC12052
• Function: repress comCDE expression; repress comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 436314..447666

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQL37_RS02430	-	436463..436612 (+)	150	WP_002994198.1	hypothetical protein	-
DQL37_RS02435 (NCTC12052_00476)	-	437007..438155 (+)	1149	WP_011054267.1	acetyl-CoA C-acyltransferase	-
DQL37_RS02440 (NCTC12052_00477)	-	438112..439359 (+)	1248	WP_038432850.1	AMP-binding protein	-
DQL37_RS02445 (NCTC12052_00478)	-	439415..440449 (+)	1035	WP_011284595.1	DUF3114 domain-containing protein	-
DQL37_RS02450 (NCTC12052_00479)	vicR	440611..441321 (+)	711	WP_002985645.1	response regulator YycF	Regulator
DQL37_RS02455 (NCTC12052_00480)	vicK	441314..442666 (+)	1353	WP_111685688.1	cell wall metabolism sensor histidine kinase VicK	Regulator
DQL37_RS02460 (NCTC12052_00481)	vicX	442670..443479 (+)	810	WP_023612763.1	MBL fold metallo-hydrolase	Regulator
DQL37_RS02465 (NCTC12052_00482)	rnc	443911..444603 (+)	693	WP_002985639.1	ribonuclease III	-

Sequence

Protein

• Length: 450 a.a.
• Molecular weight: 51419.83 Da
• Isoelectric Point: 5.4026

>NTDB_id=1138043 DQL37_RS02455 WP_111685688.1 441314..442666(+) (vicK) [Streptococcus pyogenes strain NCTC12052]
MTRDIIGNLSTFELAILILLVFVAFYFIHLAVRDYRNARIIRMMSHKIRDLINGRYTDIIDEKADIELMELSDQLNDLSD
VFRLTHENLAQEKNRLASILAYMSDGVLATDRSGKIIMINETARRQLNLSKEEALKKNITDLLEGDTSYTYRDLVSKTPV
VTVNSRNDMGEFVSLRLRFALNRRESGFISGLVVVLHDTTEQEKEERERRLFVSNVSHELRTPLTSVKSYLEALDEGALK
EDIAPSFIKVSLDETNRMMRMISDLLNLSRIDNQVTQLAVEMTNFTAFITSILNRFDLVKNQHTGTGKVYEIVRDYPITS
VWLEIDNDKMTQVIENILNNAIKYSPDGGKITVRMKTTDTQLIISISDQGLGIPKTDLPLIFDRFYRVDKARSRAQGGTG
LGLAIAKEIIKQHHGFIWAKSDYGKGSTFTIVLPYEKDAAIYEEWEEDVD

Nucleotide

• Length: 1353 bp

>NTDB_id=1138043 DQL37_RS02455 WP_111685688.1 441314..442666(+) (vicK) [Streptococcus pyogenes strain NCTC12052]
ATGACTAGAGATATCATTGGAAACTTATCCACATTTGAATTAGCGATCCTTATCTTACTTGTTTTTGTTGCTTTTTACTT
TATCCATCTTGCGGTGCGTGACTACCGAAATGCACGTATTATTCGGATGATGAGCCATAAAATCCGAGACTTGATTAATG
GTCGCTATACTGATATAATCGACGAAAAAGCAGACATTGAGTTAATGGAGCTTTCAGACCAGTTAAATGACCTGTCAGAT
GTTTTTCGCTTGACGCATGAAAATCTTGCCCAAGAAAAAAATCGCTTGGCAAGTATTTTGGCTTATATGTCAGATGGTGT
ACTTGCTACAGACCGGTCTGGTAAAATCATCATGATTAACGAGACAGCTCGCAGGCAATTAAATTTAAGTAAAGAAGAGG
CACTAAAGAAAAACATTACAGATCTGTTAGAAGGTGATACTTCATATACCTACCGTGATTTGGTATCCAAAACACCAGTG
GTAACTGTTAATAGCCGAAATGATATGGGTGAGTTTGTCTCATTACGCTTGCGCTTTGCGTTGAATAGGAGAGAGAGTGG
TTTTATTTCGGGCTTGGTTGTGGTGCTCCATGACACCACAGAACAAGAAAAAGAAGAACGTGAACGCCGTCTTTTTGTCT
CTAATGTAAGTCATGAATTAAGGACCCCTTTAACTTCGGTTAAATCCTACTTGGAGGCTCTTGATGAAGGTGCACTTAAA
GAAGATATTGCTCCAAGTTTCATAAAAGTTTCTCTTGATGAAACTAATCGGATGATGCGTATGATTTCAGATCTTTTAAA
CCTGTCTCGGATTGATAATCAAGTAACCCAATTAGCAGTAGAGATGACTAATTTTACTGCTTTTATAACTTCTATTTTAA
ACAGATTTGATTTGGTTAAAAATCAGCATACAGGTACAGGAAAAGTCTATGAAATTGTAAGAGATTACCCTATTACCTCT
GTCTGGCTTGAAATTGATAATGATAAAATGACACAGGTTATCGAGAATATTTTGAACAATGCCATTAAGTATTCTCCAGA
TGGTGGAAAAATTACAGTCCGTATGAAAACAACAGATACTCAATTAATTATTTCCATTTCAGACCAAGGACTAGGTATTC
CTAAAACAGATTTGCCTCTTATTTTTGATCGGTTCTATCGTGTAGACAAGGCAAGAAGTCGTGCCCAAGGAGGGACCGGT
CTAGGCCTTGCCATTGCTAAAGAAATCATCAAGCAGCACCATGGCTTTATCTGGGCTAAGAGTGACTATGGTAAAGGATC
GACCTTTACTATTGTCTTGCCTTATGAAAAAGATGCAGCCATCTATGAAGAATGGGAGGAAGATGTAGACTAA

Domains

Predicted by InterproScan.

• His Kinase A (phospho-acceptor) domain (HisKA) (209-273)

• PAS fold (PAS) (95-162)

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (326-436)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vicK	Streptococcus mutans UA159	72.464	92	0.667
micB	Streptococcus pneumoniae Cp1015	67.529	94.444	0.638