Detailed information NTG1137824

Bioinformatically predicted

Overview

• Name: ciaH
• Type: Regulator
• Locus tag: DQM48_RS05545
• Genome accession: NZ_LS483348
• Coordinates: 1058437..1059765 (-)
• Length: 442 a.a.
• NCBI ID: WP_020916819.1
• Uniprot ID: A0AB33ALY3
• Organism: Streptococcus lutetiensis strain NCTC8738
• Function: Required for optimal comC expression (predicted from homology) Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
IScluster/Tn	1057391..1058394	1058437..1059765	flank	43

Gene organization within MGE regions

Location: 1057391..1059765

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQM48_RS05545 (NCTC8738_01146)	ciaH	1058437..1059765 (-)	1329	WP_020916819.1	sensor histidine kinase	Regulator

Sequence

Protein

• Length: 442 a.a.
• Molecular weight: 50230.16 Da
• Isoelectric Point: 6.5190

>NTDB_id=1137824 DQM48_RS05545 WP_020916819.1 1058437..1059765(-) (ciaH) [Streptococcus lutetiensis strain NCTC8738]
MLNNIHKKLSTGTFSNFFHFFIVFTGIFIIMTTIILQIMRYGLYSSVDTTLKNAADNASDYVTRTMERSDSIQSNNSFSN
SGKSKPSSNVASLSNVSVLLYDTNGKIVNAIDAFVQFGTLASSVDEDTIGEIKDEKMTTIFGQTEKYHVLTVRVYSSDYP
TIEYATFLISVSQLDEANERYVTITVSVMIIFWMISILASIYLANWMRKPILESYEKQKRFVENASHELRTPLAVLQNRL
ESLFRRPNATILDNSESIAASLDEVRNMRILTTNLLNLARRDDGLKVELEEIQPSIFNEIFENYNMIAEENGKTFVSHNF
ADRPIKTDRTLLKQLMTILFDNAIKYTDDDGFIEFTVKTTERQTILTVADNGPGISDADKAKIFDRFYRVDKARTRQKGG
FGLGLSLAKQIVDALKGDIQVKDNHPKGTIFEVRFNRYNFGK

Nucleotide

• Length: 1329 bp

>NTDB_id=1137824 DQM48_RS05545 WP_020916819.1 1058437..1059765(-) (ciaH) [Streptococcus lutetiensis strain NCTC8738]
ATGCTGAATAACATACACAAAAAATTATCAACAGGAACGTTTTCTAATTTTTTCCATTTCTTCATTGTATTTACAGGAAT
TTTCATCATTATGACCACGATTATCTTGCAGATTATGCGTTATGGTCTATATTCTTCTGTAGATACTACTTTAAAAAATG
CAGCTGACAATGCAAGTGATTACGTCACACGAACAATGGAGCGTAGTGATTCCATACAATCTAATAATAGTTTTAGTAAT
TCTGGAAAAAGTAAACCCAGCTCAAATGTGGCAAGTTTAAGTAATGTCAGTGTGCTACTGTACGATACAAATGGGAAAAT
CGTAAATGCAATTGATGCGTTTGTCCAGTTCGGGACATTAGCATCTAGTGTTGATGAAGACACTATTGGTGAGATTAAAG
ATGAGAAAATGACAACTATCTTTGGTCAAACCGAAAAATACCATGTTTTAACGGTTAGAGTGTATAGTAGTGACTATCCA
ACGATTGAATACGCGACTTTCTTAATCAGTGTTAGTCAGCTTGATGAGGCAAACGAACGTTATGTAACCATAACAGTTTC
AGTCATGATTATTTTCTGGATGATTTCAATTTTAGCAAGTATTTACTTGGCAAATTGGATGCGTAAACCAATTTTAGAAA
GTTATGAAAAACAAAAGCGTTTTGTTGAAAATGCTAGTCACGAATTAAGAACGCCTTTAGCGGTGCTTCAAAACCGACTT
GAAAGTCTTTTTAGACGACCGAATGCAACAATTCTTGATAACAGTGAAAGTATTGCAGCGAGTCTTGACGAAGTTCGTAA
TATGCGTATTTTAACAACCAATCTTTTGAATCTTGCTAGGCGAGATGATGGATTGAAAGTTGAATTAGAAGAAATTCAAC
CTTCAATATTTAATGAAATTTTTGAGAATTACAACATGATTGCCGAAGAAAACGGTAAAACTTTTGTTTCTCATAATTTT
GCGGATCGTCCGATAAAAACTGATCGCACCTTGCTTAAACAATTGATGACAATCTTGTTTGATAATGCGATTAAGTACAC
TGATGATGACGGTTTTATTGAATTTACGGTTAAAACAACAGAACGCCAGACTATTCTAACCGTTGCTGATAATGGACCGG
GTATTAGTGACGCCGATAAAGCGAAAATTTTTGATCGCTTTTATCGCGTTGATAAGGCAAGGACACGTCAAAAAGGTGGC
TTTGGGCTTGGGCTATCTTTAGCTAAACAAATTGTTGATGCCTTAAAAGGTGACATTCAAGTTAAGGATAATCATCCAAA
AGGAACCATATTTGAAGTTCGTTTTAACCGATATAATTTTGGTAAATAA

Domains

Predicted by InterproScan.

• His Kinase A (phospho-acceptor) domain (HisKA) (218-284)

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (328-435)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaH	Streptococcus mutans UA159	59.77	98.416	0.588
ciaH	Streptococcus pneumoniae Rx1	52.403	98.869	0.518
ciaH	Streptococcus pneumoniae D39	52.403	98.869	0.518
ciaH	Streptococcus pneumoniae R6	52.403	98.869	0.518
ciaH	Streptococcus pneumoniae TIGR4	52.403	98.869	0.518