Detailed information NTG1137131

Bioinformatically predicted

Overview

• Name: vicK
• Type: Regulator
• Locus tag: DQL44_RS02350
• Genome accession: NZ_LS483335
• Coordinates: 429087..430439 (+)
• Length: 450 a.a.
• NCBI ID: WP_111677108.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain NCTC8332
• Function: repress comCDE expression; repress comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 424087..435439

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQL44_RS02325 (NCTC8332_00454)	-	424242..424811 (+)	570	WP_111677104.1	hypothetical protein	-
DQL44_RS02330 (NCTC8332_00455)	-	424780..425928 (+)	1149	WP_111677105.1	acetyl-CoA C-acyltransferase	-
DQL44_RS02335 (NCTC8332_00456)	-	425885..427132 (+)	1248	WP_111677106.1	AMP-binding protein	-
DQL44_RS02340 (NCTC8332_00457)	-	427188..428222 (+)	1035	WP_172448831.1	DUF3114 domain-containing protein	-
DQL44_RS02345 (NCTC8332_00458)	vicR	428384..429094 (+)	711	WP_002985645.1	response regulator YycF	Regulator
DQL44_RS02350 (NCTC8332_00459)	vicK	429087..430439 (+)	1353	WP_111677108.1	cell wall metabolism sensor histidine kinase VicK	Regulator
DQL44_RS02355 (NCTC8332_00460)	vicX	430443..431252 (+)	810	WP_002985641.1	MBL fold metallo-hydrolase	Regulator
DQL44_RS02360 (NCTC8332_00461)	rnc	431683..432375 (+)	693	WP_002985639.1	ribonuclease III	-

Sequence

Protein

• Length: 450 a.a.
• Molecular weight: 51347.77 Da
• Isoelectric Point: 5.4026

>NTDB_id=1137131 DQL44_RS02350 WP_111677108.1 429087..430439(+) (vicK) [Streptococcus pyogenes strain NCTC8332]
MTRDIIGNLSTFELAILILLVFVAFYFIHLAVRDYRNARIIRMMSHKIRDLINGRYTDIIDEKADIELMELSDQLNDLSD
VFRLTHENLAQEKNRLASILAYMSDGVLATDRSGKIIMINEAARKQLNLSKEEALKKNITDLLEGDTSYTYRDLVSKTPV
VTVNSRNDMGEFVSLRLRFALNRRESGFISGLVVVLHDTTEQEKEERERRLFVSNVSHELRTPLTSVKSYLEALDEGALK
EDIAPSFIKVSLDETNRMMRMISDLLNLSRIDNQVTQLAVEMTNFTAFITSILNRFDLVKNQHTGTGKVYEIVRDYPITS
VWLEIDNDKMTQVIENILNNAIKYSPDGGKITVRMKTTDTQLIISISDQGLGIPKTDLPLIFDRFYRVDKARSRAQGGTG
LGLAIAKEIIKQHHGFVWAKSDYGKGSTFTIVLPYEKDAAIYEEWEEDVD

Nucleotide

• Length: 1353 bp

>NTDB_id=1137131 DQL44_RS02350 WP_111677108.1 429087..430439(+) (vicK) [Streptococcus pyogenes strain NCTC8332]
ATGACTAGAGATATCATTGGAAACTTATCCACATTTGAATTAGCGATCCTTATCTTACTTGTTTTTGTTGCTTTTTACTT
TATCCATCTTGCGGTGCGTGATTACCGAAATGCACGTATTATTCGGATGATGAGCCATAAAATCCGAGACTTGATTAATG
GTCGCTATACTGATATAATCGACGAAAAAGCAGACATTGAGTTAATGGAGCTTTCAGACCAGTTAAATGACCTGTCAGAT
GTTTTTCGCTTGACGCATGAAAATCTTGCCCAAGAAAAAAATCGCTTGGCAAGTATTTTGGCTTATATGTCAGATGGTGT
ACTTGCTACAGACCGGTCTGGTAAAATCATCATGATTAACGAGGCAGCTCGCAAGCAATTAAATTTAAGTAAAGAAGAGG
CACTAAAGAAAAACATTACAGATTTGTTAGAAGGTGATACTTCATATACCTATCGTGATTTGGTATCCAAAACACCAGTG
GTAACTGTTAATAGCCGAAATGATATGGGTGAGTTTGTCTCATTACGCTTGCGCTTTGCGTTGAATAGGAGAGAGAGTGG
TTTTATTTCGGGCTTGGTTGTGGTGCTCCATGACACCACAGAACAAGAAAAAGAAGAACGTGAACGCCGTCTTTTTGTCT
CTAATGTAAGTCATGAATTAAGGACCCCTTTAACTTCGGTTAAATCCTACTTGGAGGCTCTTGATGAAGGTGCACTTAAA
GAAGATATTGCTCCAAGTTTCATAAAAGTTTCTCTTGATGAAACTAATCGGATGATGCGTATGATTTCAGATCTTTTAAA
CCTGTCTCGGATTGATAATCAAGTAACCCAATTAGCAGTAGAGATGACTAATTTTACTGCTTTTATAACTTCTATTTTAA
ACAGATTTGATTTGGTTAAAAATCAGCATACAGGTACAGGAAAAGTCTATGAAATTGTAAGAGATTACCCTATTACCTCT
GTCTGGCTTGAAATTGATAATGATAAAATGACACAGGTTATCGAGAATATTTTGAACAATGCCATTAAGTATTCTCCAGA
TGGTGGAAAAATTACAGTCCGTATGAAAACAACAGATACCCAATTAATTATTTCCATTTCAGACCAAGGACTAGGTATCC
CTAAAACAGATTTGCCTCTTATTTTTGATCGGTTCTATCGTGTAGACAAGGCAAGAAGTCGTGCCCAAGGAGGGACCGGT
CTAGGCCTTGCCATTGCTAAAGAAATCATCAAGCAGCACCATGGCTTTGTCTGGGCTAAGAGTGACTATGGTAAAGGATC
GACCTTTACTATTGTCTTGCCTTATGAAAAAGATGCAGCCATCTATGAAGAATGGGAGGAAGATGTAGACTAA

Domains

Predicted by InterproScan.

• PAS fold (PAS) (95-162)

• His Kinase A (phospho-acceptor) domain (HisKA) (209-273)

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (326-436)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vicK	Streptococcus mutans UA159	72.464	92	0.667
micB	Streptococcus pneumoniae Cp1015	67.294	94.444	0.636