Detailed information NTG1136684

Bioinformatically predicted

Overview

• Name: vicK
• Type: Regulator
• Locus tag: DQL07_RS02370
• Genome accession: NZ_LS483327
• Coordinates: 428715..430067 (+)
• Length: 450 a.a.
• NCBI ID: WP_111702817.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain NCTC12069
• Function: repress comCDE expression; repress comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 423715..435067

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQL07_RS02345	-	423865..424014 (+)	150	WP_002994198.1	hypothetical protein	-
DQL07_RS02350	-	424409..425556 (+)	1148	Protein_400	acetyl-CoA C-acyltransferase	-
DQL07_RS02355 (NCTC12069_00460)	-	425513..426760 (+)	1248	WP_002995606.1	AMP-binding protein	-
DQL07_RS02360 (NCTC12069_00461)	-	426816..427850 (+)	1035	WP_011284595.1	DUF3114 domain-containing protein	-
DQL07_RS02365 (NCTC12069_00462)	vicR	428012..428722 (+)	711	WP_002985645.1	response regulator YycF	Regulator
DQL07_RS02370 (NCTC12069_00463)	vicK	428715..430067 (+)	1353	WP_111702817.1	cell wall metabolism sensor histidine kinase VicK	Regulator
DQL07_RS02375 (NCTC12069_00464)	vicX	430071..430880 (+)	810	WP_002985641.1	MBL fold metallo-hydrolase	Regulator
DQL07_RS02380 (NCTC12069_00465)	rnc	431323..432015 (+)	693	WP_021733153.1	ribonuclease III	-

Sequence

Protein

• Length: 450 a.a.
• Molecular weight: 51453.93 Da
• Isoelectric Point: 5.5556

>NTDB_id=1136684 DQL07_RS02370 WP_111702817.1 428715..430067(+) (vicK) [Streptococcus pyogenes strain NCTC12069]
MTRDIIGNLSTFELAILILLVFVAFYFIHLAVRDYRNARIIRMMSHKIRYLINGRYTDIIDEKADIELMELSDQLNDLSD
VFRLTHENLAQEKNRLASILAYMSDGVLATDRSGKIIMINETARKQLNLSKEEALKKNITDLLEGDTSYTYRDLVSKTPV
VTVNSRNDMGEFVSLRLRFALNRRESGFISGLVVVLHDTTEQEKEERERRLFVSNVSHELRTPLTSVKSYLEALDEGALK
EDIAPSFIKVSLDETNRMMRMISDLLNLSRIDNQVTQLAVEMTNFTAFITSILNRFDLVKNQHTGTGKVYEIVRDYPITS
VWIEIDNDKMTQVIENILNNAIKYSPDGGKITVRMKTTDTQLIISISDQGLGIPKTDLPLIFDRFYRVDKARSRAQGGTG
LGLAIAKEIIKQHHGFIWAKSDYGKGSTFTIVLPYEKDAAIYEEWEEDLD

Nucleotide

• Length: 1353 bp

>NTDB_id=1136684 DQL07_RS02370 WP_111702817.1 428715..430067(+) (vicK) [Streptococcus pyogenes strain NCTC12069]
ATGACTAGAGATATCATTGGAAACTTATCCACATTTGAATTAGCGATCCTTATCTTACTTGTTTTTGTTGCTTTTTACTT
TATCCATCTTGCGGTGCGTGATTACCGAAATGCACGTATTATTCGGATGATGAGCCATAAAATCCGATACTTGATTAATG
GTCGCTATACTGATATAATCGACGAAAAAGCAGACATTGAGTTAATGGAGCTTTCAGACCAGTTAAATGACCTGTCAGAT
GTTTTTCGCTTGACGCATGAAAATCTTGCCCAAGAAAAAAATCGCTTGGCAAGTATTTTGGCTTATATGTCAGATGGTGT
ACTTGCTACAGACCGGTCTGGTAAAATCATCATGATTAACGAAACAGCTCGCAAGCAATTAAATTTAAGTAAAGAAGAGG
CACTAAAGAAAAACATTACAGATTTGTTAGAAGGTGATACTTCATATACCTACCGTGATTTGGTATCCAAAACACCAGTG
GTAACTGTTAATAGCCGAAATGATATGGGTGAGTTTGTCTCATTACGCTTGCGCTTTGCGTTGAATAGGAGAGAGAGTGG
TTTTATTTCGGGCTTGGTTGTGGTGCTCCATGACACCACAGAACAAGAAAAAGAAGAACGTGAACGCCGTCTTTTTGTCT
CTAATGTAAGTCATGAATTAAGGACCCCTTTAACTTCGGTTAAATCCTACTTGGAGGCTCTTGATGAAGGTGCACTTAAA
GAAGATATTGCTCCAAGTTTCATAAAAGTTTCTCTTGATGAAACTAATCGGATGATGCGTATGATTTCAGATCTTTTAAA
CCTGTCTCGGATTGATAATCAAGTAACCCAATTAGCAGTAGAGATGACTAATTTTACTGCTTTTATAACTTCTATTTTAA
ACAGATTTGATTTGGTTAAAAATCAGCATACAGGTACAGGAAAAGTCTATGAAATTGTAAGAGATTACCCTATTACCTCT
GTCTGGATTGAAATTGATAATGATAAAATGACACAGGTTATCGAGAATATTTTGAACAATGCCATTAAGTATTCTCCAGA
TGGTGGAAAAATCACAGTCCGTATGAAAACAACAGATACCCAATTAATTATTTCCATTTCAGACCAAGGACTAGGTATCC
CTAAAACAGATTTGCCTCTTATTTTTGATCGGTTCTATCGTGTAGACAAGGCAAGAAGTCGTGCCCAAGGAGGGACCGGT
CTAGGCCTTGCCATTGCTAAAGAAATCATCAAGCAGCACCATGGCTTTATCTGGGCTAAGAGTGACTATGGTAAAGGATC
GACCTTTACTATTGTCTTGCCTTATGAAAAAGATGCAGCCATCTATGAAGAATGGGAGGAAGATTTAGACTAA

Domains

Predicted by InterproScan.

• His Kinase A (phospho-acceptor) domain (HisKA) (209-273)

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (326-436)

• PAS fold (PAS) (95-162)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vicK	Streptococcus mutans UA159	72.947	92	0.671
micB	Streptococcus pneumoniae Cp1015	67.529	94.444	0.638