Detailed information    

insolico Bioinformatically predicted

Overview

Name   vraR   Type   Regulator
Locus tag   DQL80_RS09695 Genome accession   NZ_LS483302
Coordinates   1922263..1922892 (-) Length   209 a.a.
NCBI ID   WP_000153535.1    Uniprot ID   W8TS97
Organism   Staphylococcus aureus strain NCTC8726     
Function   repress expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 1917263..1927892
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DQL80_RS09665 (NCTC8726_01830) - 1917682..1918212 (-) 531 WP_000184383.1 acyl-CoA thioesterase -
  DQL80_RS09670 (NCTC8726_01831) - 1918302..1919558 (-) 1257 WP_001793983.1 aminopeptidase -
  DQL80_RS09675 (NCTC8726_01832) - 1919561..1919761 (-) 201 WP_000180460.1 DUF1128 family protein -
  DQL80_RS09680 (NCTC8726_01833) - 1919908..1920372 (+) 465 WP_000228666.1 low molecular weight protein-tyrosine-phosphatase -
  DQL80_RS09685 (NCTC8726_01834) - 1920379..1920654 (+) 276 WP_000428172.1 YtxH domain-containing protein -
  DQL80_RS09690 (NCTC8726_01835) - 1920933..1922150 (+) 1218 WP_111680448.1 YihY/virulence factor BrkB family protein -
  DQL80_RS09695 (NCTC8726_01836) vraR 1922263..1922892 (-) 630 WP_000153535.1 two-component system response regulator VraR Regulator
  DQL80_RS09700 (NCTC8726_01837) vraS 1922882..1923925 (-) 1044 WP_111680449.1 sensor histidine kinase Regulator
  DQL80_RS09705 (NCTC8726_01838) liaF 1923922..1924623 (-) 702 WP_000149064.1 cell wall-active antibiotics response protein LiaF -
  DQL80_RS09710 (NCTC8726_01839) - 1924638..1925024 (-) 387 WP_111680450.1 hypothetical protein -
  DQL80_RS09715 (NCTC8726_01840) map 1925241..1925999 (-) 759 WP_111680451.1 type I methionyl aminopeptidase -
  DQL80_RS09725 (NCTC8726_01841) - 1926474..1927460 (+) 987 WP_000999713.1 FUSC family protein -

Sequence

Protein


Download         Length: 209 a.a.        Molecular weight: 23559.32 Da        Isoelectric Point: 5.3935

>NTDB_id=1135613 DQL80_RS09695 WP_000153535.1 1922263..1922892(-) (vraR) [Staphylococcus aureus strain NCTC8726]
MTIKVLFVDDHEMVRIGISSYLSTQSDIEVVGEGASGKEAIAKAHELKPDLILMDLLMEDMDGVEATTQIKKDLPQIKVL
MLTSFIEDKEVYRALDAGVDSYILKTTSAKDIADAVRKTSRGESVFEPEVLVKMRNRMKKRAELYEMLTEREMEILLLIA
KGYSNQEIASASHITIKTVKTHVSNILSKLEVQDRTQAVIYAFQHNLIQ

Nucleotide


Download         Length: 630 bp        

>NTDB_id=1135613 DQL80_RS09695 WP_000153535.1 1922263..1922892(-) (vraR) [Staphylococcus aureus strain NCTC8726]
ATGACGATTAAAGTATTGTTTGTGGATGATCATGAAATGGTACGTATAGGAATTTCAAGTTATCTATCAACGCAAAGTGA
TATTGAAGTAGTTGGTGAAGGCGCTTCTGGTAAAGAAGCAATTGCCAAAGCACATGAGTTGAAGCCAGATTTAATTTTAA
TGGATTTACTTATGGAAGACATGGATGGTGTAGAAGCGACGACTCAGATTAAAAAAGATTTACCGCAAATTAAAGTATTA
ATGTTAACTAGTTTTATTGAAGATAAAGAGGTATATCGTGCATTAGATGCAGGTGTCGATAGTTACATTTTAAAAACAAC
AAGTGCAAAAGATATCGCCGATGCAGTTCGTAAAACTTCTAGAGGAGAATCTGTTTTTGAACCGGAAGTTTTAGTGAAAA
TGCGTAACCGTATGAAAAAGCGTGCAGAGTTATATGAAATGCTTACAGAACGAGAAATGGAAATATTATTATTGATTGCG
AAAGGTTACTCAAATCAAGAAATTGCTAGTGCATCGCATATTACTATTAAAACGGTTAAGACACATGTGAGTAACATTTT
AAGTAAGTTAGAAGTGCAAGATAGAACACAAGCTGTTATCTATGCATTCCAACATAATTTAATTCAATAG

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(5-116)

Bacterial regulatory proteins, luxR family (GerE)

(147-202)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB W8TS97

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vraR Staphylococcus aureus N315

100

100

1
  degU Bacillus subtilis subsp. subtilis str. 168

34.821

100

0.373

Multiple sequence alignment