Detailed information    

insolico Bioinformatically predicted

Overview

Name   vraR   Type   Regulator
Locus tag   BKMNNEJI_RS00465 Genome accession   NZ_LR822061
Coordinates   83925..84554 (+) Length   209 a.a.
NCBI ID   WP_000153535.1    Uniprot ID   W8TS97
Organism   Staphylococcus aureus isolate HU-14     
Function   repress expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 78925..89554
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  BKMNNEJI_RS00440 (LJDFIFNA_00076) - 79301..80287 (-) 987 WP_000999717.1 FUSC family protein -
  BKMNNEJI_RS00445 (LJDFIFNA_00077) map 80818..81576 (+) 759 WP_000636142.1 type I methionyl aminopeptidase -
  BKMNNEJI_RS00450 (LJDFIFNA_00078) - 81793..82179 (+) 387 WP_001110179.1 hypothetical protein -
  BKMNNEJI_RS00455 (LJDFIFNA_00079) liaF 82194..82895 (+) 702 WP_000149067.1 cell wall-active antibiotics response protein LiaF -
  BKMNNEJI_RS00460 (LJDFIFNA_00080) vraS 82892..83935 (+) 1044 WP_001017131.1 sensor histidine kinase Regulator
  BKMNNEJI_RS00465 (LJDFIFNA_00081) vraR 83925..84554 (+) 630 WP_000153535.1 two-component system response regulator VraR Regulator
  BKMNNEJI_RS00470 (LJDFIFNA_00082) - 84667..85884 (-) 1218 WP_000037075.1 YihY/virulence factor BrkB family protein -
  BKMNNEJI_RS00475 (LJDFIFNA_00083) - 86162..86437 (-) 276 WP_000428172.1 YtxH domain-containing protein -
  BKMNNEJI_RS00480 (LJDFIFNA_00084) - 86444..86908 (-) 465 WP_000228666.1 low molecular weight protein-tyrosine-phosphatase -
  BKMNNEJI_RS00485 (LJDFIFNA_00085) - 87055..87255 (+) 201 WP_000180460.1 DUF1128 family protein -
  BKMNNEJI_RS00490 (LJDFIFNA_00086) - 87258..88514 (+) 1257 WP_001835023.1 aminopeptidase -
  BKMNNEJI_RS00495 (LJDFIFNA_00087) - 88604..89134 (+) 531 WP_000184383.1 acyl-CoA thioesterase -

Sequence

Protein


Download         Length: 209 a.a.        Molecular weight: 23559.32 Da        Isoelectric Point: 5.3935

>NTDB_id=1132258 BKMNNEJI_RS00465 WP_000153535.1 83925..84554(+) (vraR) [Staphylococcus aureus isolate HU-14]
MTIKVLFVDDHEMVRIGISSYLSTQSDIEVVGEGASGKEAIAKAHELKPDLILMDLLMEDMDGVEATTQIKKDLPQIKVL
MLTSFIEDKEVYRALDAGVDSYILKTTSAKDIADAVRKTSRGESVFEPEVLVKMRNRMKKRAELYEMLTEREMEILLLIA
KGYSNQEIASASHITIKTVKTHVSNILSKLEVQDRTQAVIYAFQHNLIQ

Nucleotide


Download         Length: 630 bp        

>NTDB_id=1132258 BKMNNEJI_RS00465 WP_000153535.1 83925..84554(+) (vraR) [Staphylococcus aureus isolate HU-14]
ATGACGATTAAAGTATTGTTTGTGGATGATCATGAAATGGTACGTATAGGAATTTCAAGTTATCTATCAACGCAAAGTGA
TATTGAAGTAGTTGGTGAAGGCGCTTCTGGTAAAGAAGCAATTGCCAAAGCCCATGAGTTGAAGCCAGATTTAATTTTAA
TGGATTTACTTATGGAAGACATGGATGGTGTAGAAGCGACGACTCAGATTAAAAAAGATTTACCGCAAATTAAAGTATTA
ATGTTAACTAGTTTTATTGAAGATAAAGAGGTATATCGTGCATTAGATGCAGGTGTCGATAGTTACATTTTAAAAACAAC
AAGTGCAAAAGATATCGCCGATGCAGTTCGTAAAACTTCTAGAGGAGAATCTGTTTTTGAACCGGAAGTTTTAGTGAAAA
TGCGTAACCGTATGAAAAAGCGCGCAGAGTTATATGAAATGCTTACAGAACGAGAAATGGAAATATTATTATTGATTGCG
AAAGGTTACTCAAATCAAGAAATTGCTAGTGCATCGCATATTACTATTAAAACGGTTAAGACACATGTGAGTAACATTTT
AAGTAAGTTAGAAGTGCAAGATAGAACACAAGCTGTCATCTATGCATTCCAACATAATTTAATTCAATAG

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(5-116)

Bacterial regulatory proteins, luxR family (GerE)

(147-202)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB W8TS97

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vraR Staphylococcus aureus N315

100

100

1
  degU Bacillus subtilis subsp. subtilis str. 168

34.821

100

0.373

Multiple sequence alignment