Detailed information NTG1132257

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: BKMNNEJI_RS00460
• Genome accession: NZ_LR822061
• Coordinates: 82892..83935 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus isolate HU-14
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 77892..88935

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
BKMNNEJI_RS00430 (LJDFIFNA_RS00430)	-	78318..78428 (+)	111	WP_001790257.1	hypothetical protein	-
BKMNNEJI_RS00435 (LJDFIFNA_00075)	-	78457..78870 (+)	414	WP_001557448.1	hypothetical protein	-
BKMNNEJI_RS00440 (LJDFIFNA_00076)	-	79301..80287 (-)	987	WP_000999717.1	FUSC family protein	-
BKMNNEJI_RS00445 (LJDFIFNA_00077)	map	80818..81576 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
BKMNNEJI_RS00450 (LJDFIFNA_00078)	-	81793..82179 (+)	387	WP_001110179.1	hypothetical protein	-
BKMNNEJI_RS00455 (LJDFIFNA_00079)	liaF	82194..82895 (+)	702	WP_000149067.1	cell wall-active antibiotics response protein LiaF	-
BKMNNEJI_RS00460 (LJDFIFNA_00080)	vraS	82892..83935 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
BKMNNEJI_RS00465 (LJDFIFNA_00081)	vraR	83925..84554 (+)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
BKMNNEJI_RS00470 (LJDFIFNA_00082)	-	84667..85884 (-)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
BKMNNEJI_RS00475 (LJDFIFNA_00083)	-	86162..86437 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
BKMNNEJI_RS00480 (LJDFIFNA_00084)	-	86444..86908 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
BKMNNEJI_RS00485 (LJDFIFNA_00085)	-	87055..87255 (+)	201	WP_000180460.1	DUF1128 family protein	-
BKMNNEJI_RS00490 (LJDFIFNA_00086)	-	87258..88514 (+)	1257	WP_001835023.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=1132257 BKMNNEJI_RS00460 WP_001017131.1 82892..83935(+) (vraS) [Staphylococcus aureus isolate HU-14]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=1132257 BKMNNEJI_RS00460 WP_001017131.1 82892..83935(+) (vraS) [Staphylococcus aureus isolate HU-14]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1