Detailed information    

insolico Bioinformatically predicted

Overview

Name   comFA/cflA   Type   Machinery gene
Locus tag   FGL12_RS03000 Genome accession   NZ_LR594041
Coordinates   642469..643770 (+) Length   433 a.a.
NCBI ID   WP_012000102.1    Uniprot ID   A8AVW4
Organism   Streptococcus gordonii strain NCTC9124     
Function   ssDNA transport into the cell (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 637469..648770
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  FGL12_RS02975 (NCTC9124_00595) - 638211..638843 (+) 633 WP_138101145.1 response regulator transcription factor -
  FGL12_RS02980 (NCTC9124_00596) - 638931..640334 (+) 1404 WP_012000098.1 Cof-type HAD-IIB family hydrolase -
  FGL12_RS02985 (NCTC9124_00597) - 640331..640717 (+) 387 WP_012000099.1 S1 RNA-binding domain-containing protein -
  FGL12_RS02990 (NCTC9124_00598) cysK 640754..641683 (-) 930 WP_012000100.1 cysteine synthase A -
  FGL12_RS02995 (NCTC9124_00599) - 641781..642413 (-) 633 WP_041789573.1 YigZ family protein -
  FGL12_RS03000 (NCTC9124_00600) comFA/cflA 642469..643770 (+) 1302 WP_012000102.1 DEAD/DEAH box helicase Machinery gene
  FGL12_RS03005 (NCTC9124_00601) comFC/cflB 643767..644432 (+) 666 WP_012000103.1 ComF family protein Machinery gene
  FGL12_RS03010 (NCTC9124_00602) raiA 644520..645062 (+) 543 WP_012000104.1 ribosome-associated translation inhibitor RaiA -

Sequence

Protein


Download         Length: 433 a.a.        Molecular weight: 49301.30 Da        Isoelectric Point: 8.3754

>NTDB_id=1127481 FGL12_RS03000 WP_012000102.1 642469..643770(+) (comFA/cflA) [Streptococcus gordonii strain NCTC9124]
MLELQDCLGRIFTKEQLPTELLKIAQRLSSVFEKKGELFCSRCHSQIDKERNLLPIGAYYCRECILLGRVRSDEDLYYFS
QESFPIISSLKWLGQLTEYQERVSKGLLEGVQSKQDTLVHAVTGAGKTEMIYQVVAQVLDQGGAVCIASPRIDVCLELYR
RLKGDFFCDISLLHGESDPYSRSPLVIATTHQLLKFYQAFDLLIVDEVDAFPYVDNPVLYHAVEQAVKNEGTTIFLTATS
TDELDKKVQKGILKRLSLPRRFHGNPLIIPQKVWLSDLNKDLKKAKLPAKLIKYLIKQRKTRFPLLIFASEIKKGQEIKQ
VLQKYFPEETVGFVASTTENRLEIVQDFRDKKISILITTTILERGVTFPCVDVIVLEANHRLFTRSALVQIGGRVGRSME
RPTGDLLFFHDGTNIQIEKAINEIKAMNREAGL

Nucleotide


Download         Length: 1302 bp        

>NTDB_id=1127481 FGL12_RS03000 WP_012000102.1 642469..643770(+) (comFA/cflA) [Streptococcus gordonii strain NCTC9124]
ATGTTAGAATTGCAAGATTGTCTCGGTCGAATTTTTACTAAAGAACAGTTACCTACTGAACTTCTGAAGATAGCTCAAAG
ACTATCATCAGTTTTTGAAAAAAAGGGAGAACTTTTTTGTTCTCGCTGCCACAGTCAAATTGATAAGGAAAGAAATTTAT
TACCAATTGGTGCATATTATTGTAGAGAATGCATTCTTCTAGGGAGAGTGCGTAGTGACGAAGATCTTTATTATTTTTCT
CAAGAATCTTTTCCTATAATATCGAGTTTGAAATGGCTCGGCCAATTGACAGAATATCAGGAAAGAGTTTCTAAGGGATT
ACTTGAAGGAGTACAAAGTAAACAGGATACTTTAGTCCACGCTGTAACTGGAGCAGGGAAAACGGAAATGATCTATCAAG
TAGTTGCTCAGGTGTTAGATCAAGGAGGGGCTGTCTGTATAGCTAGTCCTCGGATAGATGTCTGTTTGGAACTGTACCGA
CGTTTAAAAGGAGATTTCTTCTGTGATATTTCCCTTTTGCATGGGGAGTCCGACCCCTATTCACGGAGTCCCCTAGTGAT
TGCAACAACTCATCAACTACTAAAATTTTACCAAGCATTTGATCTACTCATTGTTGATGAGGTGGATGCCTTTCCCTATG
TAGATAATCCCGTGCTTTATCATGCAGTCGAGCAAGCAGTTAAAAATGAAGGAACTACAATATTCTTAACGGCTACGTCA
ACAGATGAGCTTGATAAAAAAGTTCAAAAGGGAATTTTAAAAAGGCTAAGTTTGCCAAGACGCTTTCATGGAAATCCCTT
GATTATCCCACAAAAAGTATGGCTTTCTGATCTAAATAAAGACCTTAAAAAAGCTAAGCTACCAGCTAAGTTAATCAAAT
ATCTAATAAAACAAAGAAAAACCAGATTTCCGCTCTTGATTTTTGCTTCGGAGATTAAGAAAGGACAAGAGATAAAGCAA
GTCTTACAGAAATATTTTCCAGAAGAAACTGTAGGCTTCGTAGCCTCTACAACGGAAAATAGATTAGAAATTGTGCAAGA
TTTCCGAGATAAAAAAATAAGTATATTGATCACAACAACCATATTAGAAAGAGGTGTAACCTTTCCTTGTGTTGATGTTA
TCGTTTTAGAAGCTAACCATCGTCTCTTTACAAGGAGTGCTTTAGTACAAATTGGCGGGCGAGTAGGAAGAAGTATGGAA
CGACCTACAGGTGACTTACTATTTTTTCATGATGGCACTAATATACAGATAGAAAAAGCAATCAATGAAATTAAAGCAAT
GAATAGAGAGGCTGGCTTATGA

Domains

Predicted by InterproScan.

DEAD/DEAH box helicase (DEAD)

(97-245)

Helicase conserved C-terminal domain (Helicase_C)

(290-397)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A8AVW4

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comFA/cflA Streptococcus pneumoniae TIGR4

69.393

98.845

0.686
  comFA/cflA Streptococcus pneumoniae Rx1

69.393

98.845

0.686
  comFA/cflA Streptococcus pneumoniae D39

69.393

98.845

0.686
  comFA/cflA Streptococcus pneumoniae R6

69.393

98.845

0.686
  comFA/cflA Streptococcus mitis NCTC 12261

69.484

98.383

0.684
  comFA/cflA Streptococcus mitis SK321

69.484

98.383

0.684
  comFA Lactococcus lactis subsp. cremoris KW2

54.569

90.993

0.497
  comFA Latilactobacillus sakei subsp. sakei 23K

39.302

99.307

0.39

Multiple sequence alignment