Detailed information NTG1122398

Bioinformatically predicted

Overview

• Name: letS
• Type: Regulator
• Locus tag: EL239_RS05490
• Genome accession: NZ_LR134374
• Coordinates: 1261807..1264563 (+)
• Length: 918 a.a.
• NCBI ID: WP_058482311.1
• Uniprot ID: A0A0W0Z965
• Organism: Legionella spiritensis strain NCTC12082
• Function: regulate competence development (predicted from homology) Competence regulation

Genomic Context

Location: 1256807..1269563

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EL239_RS05470 (NCTC12082_01112)	-	1256962..1257546 (-)	585	WP_058482314.1	hypothetical protein	-
EL239_RS05475 (NCTC12082_01113)	-	1257716..1258747 (+)	1032	WP_126338715.1	hypothetical protein	-
EL239_RS05480 (NCTC12082_01114)	-	1258753..1260204 (-)	1452	WP_126338716.1	protein adenylyltransferase SelO	-
EL239_RS05485 (NCTC12082_01115)	gltX	1260241..1261656 (-)	1416	WP_126338717.1	glutamate--tRNA ligase	-
EL239_RS05490 (NCTC12082_01116)	letS	1261807..1264563 (+)	2757	WP_058482311.1	two-component system sensor histidine kinase LetS	Regulator
EL239_RS05495 (NCTC12082_01117)	-	1264593..1265828 (+)	1236	WP_126338718.1	6-phosphofructokinase	-
EL239_RS05500 (NCTC12082_01118)	pilA2	1265986..1266393 (-)	408	WP_126338719.1	pilin	Machinery gene
EL239_RS05505 (NCTC12082_01119)	pilA2	1266501..1266911 (-)	411	WP_126338720.1	pilin	Machinery gene
EL239_RS05510 (NCTC12082_01120)	-	1267264..1267581 (+)	318	WP_126338721.1	BolA family protein	-
EL239_RS05515 (NCTC12082_01121)	-	1267574..1268017 (+)	444	WP_126338722.1	secondary thiamine-phosphate synthase enzyme YjbQ	-
EL239_RS05520 (NCTC12082_01122)	-	1268091..1269488 (+)	1398	WP_126339973.1	APC family permease	-

Sequence

Protein

• Length: 918 a.a.
• Molecular weight: 103088.21 Da
• Isoelectric Point: 6.8499

>NTDB_id=1122398 EL239_RS05490 WP_058482311.1 1261807..1264563(+) (letS) [Legionella spiritensis strain NCTC12082]
MKGLGIKYQLRLTTLIPVLLVAVLFAVIYNGQFSKDLTQHMSRLGESYIRQLLPAAQLAMMRNDRRILQGLIDASTINPE
IISLAFYNADGQLIAYRGGKHSINKPIKPLEYTGDYIESTQTAPYSINFLAPITIPKYNLYTPGLFQSTPDITNLRPDDI
LGWLSIDLDTKSMIIKRYQMYIITIFITLVGLLVSLSIHYFLSRRLYLPIARLRRSMKQILSNEFETHIAVTSKGELGLV
EKGCAHLQKQYLDTVRDLNHHIEVATEDLQQSLELLEEKNIELTMEKKKTEEKSRQKSEFIANMSHEIRTPMNGVIGFTN
VLLESKLDPLQLDYVKTIKSSAQDLLTIINDILDYSKMDAGKLSLDCIPLDLRACIDEVLTLAAPNAHKKGIDLIPSTDI
AVPKTVLGDPIRIKQILTNLVNNAIKFTERGYVLIKTVVEQESEKDYSLCISVTDTGIGISAEDQTKLFNAFNQADTTIT
RRFGGSGLGLVICKKLAEEMKGRITLTSELHKGSTFTVRIRLEKFPAYEAEKHQNNRFDDLKAICFDDNPLHLEGICNGL
EYCGIHSVPVTTLKELEQALTERKDCKIALVNVNDGCEEQIAGILKNHTTPTILISKTVIHDPQSLGGCAFLFRPISIQK
LQDTIESLLNQKIHNKASMEANHELDKLRAQLRLSHPDVLIAEDNPVNRMLLQSFLNEGAQVETVQDGEEAVKASLGKRY
NIILLDLQMPKLGGIDAAKLIHQDSLLNKSTPIVIISADQVSLSADKLKQAGIHLCLQKPIEEKQFLTHLLQLLTKNKTI
AIDWQLCIQKVSGNQALAEEFLTRFVAELRKNRQEFIQLFHNKDIKNLEKAAHKLHGACCFCGVPRLQSQVTRLENQAGT
AQDIKELETAFAALIRCIDDVLDEFDNLYNTSSSDSQK

Nucleotide

• Length: 2757 bp

>NTDB_id=1122398 EL239_RS05490 WP_058482311.1 1261807..1264563(+) (letS) [Legionella spiritensis strain NCTC12082]
ATGAAAGGATTAGGCATCAAATACCAGTTGCGCCTGACTACTTTGATACCGGTATTGCTGGTCGCGGTACTGTTTGCCGT
GATCTATAACGGCCAGTTCAGCAAGGATTTAACGCAACATATGTCCCGTTTGGGCGAATCGTATATACGACAACTTCTCC
CGGCAGCCCAGCTTGCCATGATGCGTAACGACCGACGTATTCTCCAGGGATTAATCGATGCCTCCACGATTAATCCGGAA
ATTATCTCACTGGCATTTTATAACGCGGACGGCCAGTTAATTGCTTATCGGGGAGGGAAACACTCCATTAACAAACCGAT
CAAACCCCTCGAATACACCGGAGACTACATCGAAAGCACCCAAACGGCCCCGTACAGTATTAATTTTCTGGCCCCGATTA
CCATCCCCAAATATAATCTCTACACTCCGGGACTCTTTCAATCCACACCGGATATCACCAACCTGCGCCCGGATGACATA
TTGGGATGGCTGTCTATTGATCTTGATACCAAGTCCATGATCATCAAGCGTTATCAAATGTATATCATCACCATTTTCAT
TACCCTCGTCGGCCTGTTGGTCAGCTTAAGCATCCATTATTTCCTTTCCAGGCGTTTATACCTGCCCATCGCCCGTTTAC
GGCGCAGCATGAAACAAATCCTGAGCAACGAATTTGAAACGCATATTGCGGTCACCAGCAAAGGCGAGCTGGGCCTCGTT
GAAAAAGGATGCGCCCACTTGCAAAAGCAATATCTCGATACCGTTCGCGATCTCAATCACCATATTGAAGTAGCGACGGA
AGATTTACAGCAAAGTCTTGAATTGCTGGAAGAAAAAAACATCGAACTCACTATGGAAAAGAAAAAGACGGAAGAGAAAA
GCCGTCAGAAATCCGAATTCATAGCCAATATGAGTCATGAAATCAGAACACCGATGAATGGTGTGATTGGCTTTACCAAT
GTTTTACTGGAAAGCAAGCTGGATCCATTGCAGCTGGATTATGTGAAAACCATCAAATCATCCGCCCAGGATTTATTAAC
CATTATCAACGACATTCTCGATTATTCCAAAATGGATGCCGGAAAACTAAGCCTGGACTGTATTCCTCTGGATTTGAGAG
CCTGTATCGATGAAGTGCTAACCCTGGCGGCTCCTAACGCCCATAAAAAAGGCATCGACCTGATTCCCTCAACGGATATC
GCTGTTCCTAAAACCGTCCTCGGCGATCCCATACGTATCAAGCAGATTCTCACTAATCTGGTCAACAACGCCATAAAATT
TACCGAGCGTGGCTATGTGCTGATAAAAACCGTCGTCGAACAGGAATCGGAAAAAGACTATTCCTTATGTATTTCCGTCA
CAGACACCGGCATCGGTATTTCAGCCGAAGATCAGACCAAACTGTTTAATGCCTTTAACCAGGCGGACACTACCATTACC
CGACGGTTCGGGGGATCCGGGCTTGGTCTGGTGATTTGCAAAAAACTGGCTGAGGAAATGAAAGGACGTATTACCCTGAC
CAGCGAACTGCACAAGGGTTCAACCTTCACCGTGCGGATCCGGCTTGAAAAATTCCCGGCGTATGAGGCGGAAAAGCATC
AAAATAACCGTTTTGATGATCTGAAAGCGATTTGTTTTGATGATAACCCCCTGCATCTGGAAGGTATATGCAACGGGCTT
GAATACTGCGGTATCCATTCTGTTCCGGTAACGACTCTGAAAGAACTGGAACAGGCTTTAACGGAAAGAAAGGACTGTAA
AATAGCGTTGGTCAACGTCAATGACGGATGCGAGGAACAAATCGCCGGGATTTTGAAAAATCACACCACGCCAACTATTC
TCATATCCAAAACGGTCATTCATGATCCGCAATCGCTGGGCGGCTGTGCCTTTTTATTTCGTCCAATCAGCATCCAGAAA
CTACAGGATACGATCGAATCACTGCTTAACCAAAAAATACACAACAAAGCGTCCATGGAAGCAAACCATGAACTGGACAA
ACTGCGCGCACAGCTTCGCCTTTCCCATCCGGATGTGTTAATTGCCGAAGACAATCCGGTCAACCGCATGCTTCTTCAAT
CATTCCTGAATGAAGGCGCCCAGGTTGAAACGGTGCAAGACGGTGAGGAAGCCGTTAAGGCATCGCTTGGCAAACGCTAT
AATATTATTCTTCTTGATTTGCAAATGCCAAAACTGGGTGGTATTGACGCCGCGAAATTGATACATCAGGATTCATTACT
TAACAAATCAACACCGATTGTTATCATCAGCGCTGATCAAGTCAGCTTGTCCGCTGACAAACTGAAACAAGCCGGCATCC
ATCTCTGTCTGCAAAAGCCCATTGAAGAAAAACAATTTTTGACTCATTTGCTGCAGTTACTGACCAAAAACAAAACCATT
GCCATTGACTGGCAACTCTGTATCCAGAAAGTTTCAGGAAATCAGGCGCTTGCCGAGGAATTTCTCACCCGCTTTGTTGC
CGAACTTCGTAAAAACCGTCAGGAATTTATCCAATTATTTCATAACAAGGATATTAAAAATCTGGAAAAAGCGGCCCATA
AACTTCATGGTGCCTGCTGTTTTTGCGGCGTTCCACGCCTGCAATCCCAGGTAACCCGTCTGGAAAACCAGGCCGGAACA
GCGCAGGATATTAAAGAACTCGAAACCGCATTCGCAGCTCTCATACGCTGTATTGATGACGTTCTGGATGAATTTGACAA
TTTATACAATACCAGTTCATCGGATTCACAAAAATAA

Domains

Predicted by InterproScan.

• Hpt domain (Hpt) (820-896)

• His Kinase A (phospho-acceptor) domain (HisKA) (297-361)

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (408-523)

• Response regulator receiver domain (Response_reg) (679-789)

• Single cache domain 4 (sCache_4) (35-179)

3D structure

• AlphaFold DB: A0A0W0Z965

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
letS	Legionella pneumophila strain ERS1305867	68.456	99.455	0.681