Detailed information NTG1121268

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: EL136_RS03880
• Genome accession: NZ_LR134317
• Coordinates: 809825..810562 (-)
• Length: 245 a.a.
• NCBI ID: WP_154803854.1
• Uniprot ID: A0A7Z8ZWL9
• Organism: Streptococcus equi subsp. zooepidemicus strain NCTC6180
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 804825..815562

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EL136_RS03855 (NCTC6180_00791)	-	805026..805877 (-)	852	WP_012515597.1	thioredoxin family protein	-
EL136_RS03860 (NCTC6180_00792)	-	806670..806900 (-)	231	WP_043038961.1	Blp family class II bacteriocin	-
EL136_RS03865 (NCTC6180_00793)	-	807162..808325 (-)	1164	WP_154803853.1	ABC transporter permease subunit	-
EL136_RS03870 (NCTC6180_00794)	-	808331..809185 (-)	855	WP_012515593.1	ABC transporter ATP-binding protein	-
EL136_RS03875 (NCTC6180_00795)	-	809252..809452 (-)	201	WP_012679509.1	ComC/BlpC family leader-containing pheromone/bacteriocin	-
EL136_RS03880 (NCTC6180_00796)	comE/blpR	809825..810562 (-)	738	WP_154803854.1	response regulator transcription factor	Regulator
EL136_RS03885 (NCTC6180_00797)	-	811334..811639 (-)	306	WP_154803855.1	acetate kinase	-
EL136_RS03890 (NCTC6180_00798)	-	811641..811979 (-)	339	WP_012677982.1	cupin domain-containing protein	-
EL136_RS03895 (NCTC6180_00799)	-	812007..812762 (-)	756	WP_154803856.1	class I SAM-dependent methyltransferase	-
EL136_RS03900 (NCTC6180_00800)	-	813022..813477 (+)	456	WP_012515587.1	DUF1836 domain-containing protein	-
EL136_RS03905 (NCTC6180_00801)	trhA	813461..814111 (+)	651	WP_154803857.1	PAQR family membrane homeostasis protein TrhA	-
EL136_RS03910 (NCTC6180_00802)	-	814222..815127 (+)	906	WP_154803858.1	diacylglycerol/lipid kinase family protein	-

Sequence

Protein

• Length: 245 a.a.
• Molecular weight: 28930.40 Da
• Isoelectric Point: 7.8796

>NTDB_id=1121268 EL136_RS03880 WP_154803854.1 809825..810562(-) (comE/blpR) [Streptococcus equi subsp. zooepidemicus strain NCTC6180]
MNIFILEDDLGQQFRLEMKIQEILDKHHWTCDRFEVYGKPYQLLANVTERGRHQLFFLDIQIRNDEKKGLAVAREIRKRD
PYALIVFVTTHSELMPVSFRYQVSALDFIDKELSMKHFSDRIERAIIYAYEEQENVTSEGLFIFVTAKAQVQVPFSSLLF
IETSSTPHKLILHSQNERIEFYGFLSEVLKQDPRLVQCHRSYVINPYNVSFLDRDKRLLYFKNGQSCMVSRLKMKALEAS
IKALH

Nucleotide

• Length: 738 bp

>NTDB_id=1121268 EL136_RS03880 WP_154803854.1 809825..810562(-) (comE/blpR) [Streptococcus equi subsp. zooepidemicus strain NCTC6180]
ATGAATATTTTTATTCTCGAAGATGATCTAGGCCAACAGTTTAGGCTTGAGATGAAGATTCAAGAGATATTGGATAAGCA
TCACTGGACTTGTGATCGTTTTGAAGTTTATGGAAAGCCCTACCAGCTTCTGGCAAATGTTACAGAGAGAGGCAGGCATC
AGCTTTTCTTTCTCGATATTCAAATTCGAAATGATGAGAAAAAGGGCTTAGCTGTTGCTCGTGAGATCAGAAAGCGTGAC
CCTTATGCCCTCATTGTTTTTGTCACCACACATTCTGAGCTTATGCCAGTTTCTTTTCGTTATCAGGTGTCTGCTCTAGA
TTTTATCGATAAGGAATTGTCAATGAAACATTTCTCAGATAGGATTGAAAGAGCCATTATATATGCTTATGAAGAGCAAG
AAAATGTAACCTCAGAGGGCTTATTTATTTTTGTAACGGCTAAGGCTCAGGTGCAGGTTCCTTTTTCAAGCCTATTGTTC
ATTGAGACCTCTAGTACTCCTCACAAGTTGATTTTGCATTCTCAAAACGAGCGAATAGAATTTTATGGCTTTCTTTCAGA
GGTTCTTAAGCAAGATCCCAGACTAGTCCAATGTCATCGTTCTTATGTTATCAATCCTTACAATGTTTCGTTTCTTGATC
GTGATAAGCGTTTACTCTATTTCAAGAATGGGCAGTCTTGCATGGTTTCAAGACTAAAAATGAAAGCACTTGAGGCGTCT
ATTAAGGCTTTGCATTGA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-240)

• Response regulator receiver domain (Response_reg) (18-122)

3D structure

• AlphaFold DB: A0A7Z8ZWL9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	54.132	98.776	0.535
comE/comE1	Streptococcus equinus JB1	45.455	98.776	0.449
comE/comE2	Streptococcus equinus JB1	37.295	99.592	0.371