Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaH   Type   Regulator
Locus tag   EL070_RS04650 Genome accession   NZ_LR134284
Coordinates   881339..882649 (+) Length   436 a.a.
NCBI ID   WP_011054528.1    Uniprot ID   A0A4U9BXV0
Organism   Streptococcus pyogenes strain NCTC8232     
Function   Required for optimal comC expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 876339..887649
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EL070_RS04630 (NCTC8232_00923) phoU 876931..877584 (+) 654 WP_002984514.1 phosphate signaling complex protein PhoU -
  EL070_RS04640 (NCTC8232_00924) - 877789..880326 (+) 2538 WP_111705628.1 M1 family metallopeptidase -
  EL070_RS04645 (NCTC8232_00925) ciaR 880672..881346 (+) 675 WP_002984519.1 response regulator transcription factor Regulator
  EL070_RS04650 (NCTC8232_00926) ciaH 881339..882649 (+) 1311 WP_011054528.1 sensor histidine kinase Regulator
  EL070_RS04655 (NCTC8232_00927) rpsT 882774..883022 (-) 249 WP_009881183.1 30S ribosomal protein S20 -
  EL070_RS04660 (NCTC8232_00928) coaA 883076..883996 (-) 921 WP_002984525.1 type I pantothenate kinase -
  EL070_RS04665 (NCTC8232_00929) - 884264..884857 (+) 594 WP_111705875.1 class I SAM-dependent methyltransferase -
  EL070_RS04670 (NCTC8232_00930) - 885511..885900 (+) 390 WP_011285547.1 cytidine deaminase -
  EL070_RS04675 (NCTC8232_00931) - 885994..887046 (+) 1053 WP_126405134.1 BMP family lipoprotein -

Sequence

Protein


Download         Length: 436 a.a.        Molecular weight: 50112.66 Da        Isoelectric Point: 9.2692

>NTDB_id=1120109 EL070_RS04650 WP_011054528.1 881339..882649(+) (ciaH) [Streptococcus pyogenes strain NCTC8232]
MNKLKKEILSDNYNHFFHFFAVFTGIFVIMTIIILQIMRFGVYSSVDSSLVSVSNNASSYANRTMARISSFYFDTENNII
KALPDSDSSKLLGTPAANTDIILFSANGTILNAFDAFSNYQNFHLDKRRLGSIETTSLMNFYGQEEKYHTITVRVHIKNY
PAVAYMMAVVNVEQLDRANERYERIIIIVMSVFWLISILASIYLAKWSRKPILESYEKQKMFVENASHELRTPLAVLQNR
LESLFRKPNETILENSEHLASSLDEVRNMRILTTNLLNLARRDDGINPQWTHLDTDFFNAIFENYELVAKEYGKIFYFQN
QVNRSLRMDKALLKQLITILFDNAIKYTDKNGIIEIIVKTTDKNLLISVIDNGPGITDEEKKKIFDRFYRVDKARTRQTG
GFGLGLALAQQIVMSLKGNITVKDNDPKGSIFEVKL

Nucleotide


Download         Length: 1311 bp        

>NTDB_id=1120109 EL070_RS04650 WP_011054528.1 881339..882649(+) (ciaH) [Streptococcus pyogenes strain NCTC8232]
ATGAATAAATTAAAAAAAGAGATTTTATCAGATAACTATAACCACTTTTTTCATTTTTTTGCGGTTTTTACAGGTATTTT
TGTCATTATGACTATTATTATCTTACAGATTATGCGGTTTGGCGTTTATTCGTCAGTTGACAGTAGTTTAGTTTCTGTTA
GTAATAATGCAAGTAGCTATGCTAATCGTACGATGGCTAGAATATCTTCTTTTTACTTTGATACTGAAAATAACATTATT
AAGGCGCTGCCTGATTCAGATAGTTCTAAGTTATTAGGAACGCCTGCAGCTAATACAGATATCATTTTGTTTAGTGCTAA
TGGAACAATTTTAAATGCTTTTGATGCGTTTTCTAACTATCAAAATTTTCATTTAGATAAACGCCGGTTGGGGAGTATTG
AAACCACCAGTTTAATGAATTTTTATGGACAAGAAGAAAAATACCATACGATAACTGTAAGGGTTCATATCAAAAATTAT
CCTGCAGTTGCCTATATGATGGCAGTAGTAAATGTGGAACAATTAGACCGCGCTAATGAACGTTACGAGCGCATTATTAT
TATAGTTATGAGTGTTTTTTGGCTAATTTCTATTTTAGCAAGTATTTATTTAGCCAAGTGGAGCAGAAAACCTATTTTAG
AAAGCTATGAAAAACAAAAAATGTTTGTTGAAAATGCTAGTCATGAATTAAGGACCCCTTTGGCGGTCTTACAGAATCGT
CTGGAATCGCTTTTTCGTAAGCCCAACGAAACGATATTAGAAAATAGTGAGCATCTCGCTTCTAGTTTAGACGAGGTTCG
CAACATGCGCATCTTAACAACTAATTTATTAAATTTAGCAAGACGAGATGATGGCATTAATCCACAGTGGACTCATTTAG
ATACAGATTTTTTTAATGCTATTTTTGAGAATTATGAACTAGTTGCTAAAGAATATGGAAAAATATTTTATTTTCAGAAC
CAAGTCAATAGATCGTTAAGAATGGATAAGGCTTTACTAAAACAATTAATAACGATTTTATTTGACAATGCTATTAAATA
TACAGATAAAAATGGTATTATTGAAATTATAGTGAAAACAACGGACAAAAATTTATTAATTTCTGTTATTGATAATGGTC
CAGGGATAACAGATGAAGAAAAGAAAAAGATTTTTGATCGTTTTTATCGAGTTGACAAAGCTAGAACACGGCAAACAGGT
GGATTTGGCTTGGGGTTGGCTTTAGCTCAGCAAATCGTGATGTCTTTAAAAGGAAATATTACAGTAAAGGATAATGATCC
TAAAGGTAGTATTTTTGAAGTCAAACTATAA

Domains

Predicted by InterproScan.

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(329-436)

His Kinase A (phospho-acceptor) domain (HisKA)

(220-285)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A4U9BXV0

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaH Streptococcus mutans UA159

57.895

100

0.58
  ciaH Streptococcus pneumoniae Rx1

51.37

100

0.516
  ciaH Streptococcus pneumoniae D39

51.37

100

0.516
  ciaH Streptococcus pneumoniae R6

51.37

100

0.516
  ciaH Streptococcus pneumoniae TIGR4

51.37

100

0.516

Multiple sequence alignment