Detailed information NTG0111994

Bioinformatically predicted

Overview

• Name: letS
• Type: Regulator
• Locus tag: LOA_RS04155
• Genome accession: NZ_CP004006
• Coordinates: 835282..838041 (-)
• Length: 919 a.a.
• NCBI ID: WP_025385263.1
• Uniprot ID: W0B9F3
• Organism: Legionella oakridgensis ATCC 33761 = DSM 21215
• Function: regulate competence development (predicted from homology) Competence regulation

Genomic Context

Location: 830282..843041

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
LOA_RS04130 (Loa_00922)	-	832028..832480 (-)	453	WP_025385258.1	secondary thiamine-phosphate synthase enzyme YjbQ	-
LOA_RS04135 (Loa_00923)	-	832473..832790 (-)	318	WP_025385259.1	BolA family protein	-
LOA_RS04145 (Loa_00924)	pilA2	833354..833803 (+)	450	WP_118996625.1	pilin	Machinery gene
LOA_RS04150 (Loa_00925)	-	833847..835082 (-)	1236	WP_025385262.1	6-phosphofructokinase	-
LOA_RS04155 (Loa_00926)	letS	835282..838041 (-)	2760	WP_025385263.1	two-component system sensor histidine kinase LetS	Regulator
LOA_RS04160 (Loa_00927)	gltX	838286..839698 (+)	1413	WP_025385264.1	glutamate--tRNA ligase	-
LOA_RS04165 (Loa_00928)	-	839785..840066 (+)	282	WP_025385265.1	hypothetical protein	-
LOA_RS04170 (Loa_00929)	-	840121..840537 (+)	417	WP_025385266.1	hypothetical protein	-
LOA_RS04175 (Loa_00930)	-	840675..841271 (+)	597	WP_025385267.1	hypothetical protein	-
LOA_RS04180 (Loa_00931)	-	841376..841708 (-)	333	WP_025385268.1	hypothetical protein	-
LOA_RS04185 (Loa_00932)	-	841781..842089 (+)	309	WP_025385269.1	DUF1840 domain-containing protein	-

Sequence

Protein

• Length: 919 a.a.
• Molecular weight: 103849.96 Da
• Isoelectric Point: 7.0522

>NTDB_id=111994 LOA_RS04155 WP_025385263.1 835282..838041(-) (letS) [Legionella oakridgensis ATCC 33761 = DSM 21215]
MKSIGIKYQLRITTLIPVLVVALLFALFYNGKFSRDLKQHTSHLGEAYIRQLLPAAQLALLRDDKRILQGLIDASTINQE
VQSLAFYNAKGQLLAYRGGKHSLKHPFTPPDYTGDYIESRQINPYSINFLAPITVPKFNLYSFTPFKSPTSMPDFQADDI
LGWLSIDIDTQATLIKRYQMYIVTIFITLFGLLTGLSIHYFFSKKIYIPIARLRRSMKQILSNEFETEIKLSSQAELGTI
EQGCAHLQKQYLSMVKDLNQYIETATTDLQKNLELLEEKNIELSLDKKKSEEKSRQKSEFIANMSHEIRTPMNGILGFTN
VLLESKLDSLQQEYVKTIKSSAQDLLAIINDILDYSKMDAGKLHLDYIPLDIRACIDDVVALLAPHAHKKGLDLIPATDI
AVPKTVLGDPLRLKQIISNLVSNAIKFTDHGYVLIRTHIEQESEKDYTICLAISDTGIGICSEDQTTLFNAFNQADTTIT
RRFGGSGLGLVISKKLAEHMQGRISLSSEPHKGSTFSVHIKLAKLMAYEIEKHQIHRFGNLKVLCFDDNPLHLEALCNGL
GYWGIQCIRIDAFNQLEQAFYQHQDCHLAFVSVNQGCEQQVAEVLRKQSMPCVLVSKWPIQNYQALGAQGFLFKPPNIQK
LHETIEHLFHQSSIPTSAESMHIQELDTLRARLRLAKPNLLVAEDNPINRMLLNALLSEKTCIDTVEDGQQAVTKCNSKR
FHAILLDLQMPKLDGFEAARLIRQQSLLNKTTPIILLSANSMNENNESMQKLGIDLCLQKPLDEASLLRHLLKIINQTTA
SAINWTLCVQKVSGNQALATEFLDRFVEELHKNREELLQLMASGQIKNLERAAHKLHGACCFCGVPQLQSQVAQLEALAK
QASHIDELQMPFSQFIQSLDAVIEEYEHSYRARDIVELL

Nucleotide

• Length: 2760 bp

>NTDB_id=111994 LOA_RS04155 WP_025385263.1 835282..838041(-) (letS) [Legionella oakridgensis ATCC 33761 = DSM 21215]
GTGAAAAGCATTGGGATTAAATATCAACTTAGAATAACGACTTTAATCCCAGTATTAGTGGTCGCTCTTTTATTTGCACT
GTTTTATAATGGCAAATTCAGCCGCGATTTAAAACAGCACACTTCTCATTTAGGCGAAGCCTATATTCGCCAGCTTTTGC
CCGCTGCTCAATTAGCTTTATTAAGAGATGACAAGCGTATTCTTCAGGGCTTGATCGATGCATCCACCATTAATCAGGAA
GTGCAATCACTGGCTTTTTATAATGCTAAAGGGCAGTTGTTGGCTTATCGCGGAGGCAAACACTCCTTGAAACACCCGTT
TACTCCCCCTGACTACACCGGTGATTACATTGAAAGCCGACAAATTAATCCATACAGCATCAATTTTTTAGCTCCCATTA
CCGTTCCAAAGTTCAATCTATATTCCTTTACGCCATTTAAGTCCCCAACCTCCATGCCTGATTTTCAAGCTGATGATATC
CTGGGTTGGTTATCCATTGATATTGATACGCAGGCTACATTAATCAAACGCTATCAAATGTACATTGTCACCATCTTCAT
TACTTTATTTGGCTTACTGACTGGCTTGAGTATTCATTATTTCTTTTCCAAAAAGATTTACATTCCCATCGCACGACTGC
GGCGCAGCATGAAGCAAATTCTTAGTAATGAATTTGAAACAGAAATCAAATTATCGAGTCAAGCAGAACTTGGTACCATC
GAACAAGGCTGCGCTCATTTACAAAAGCAGTATTTAAGCATGGTCAAAGACTTAAACCAGTATATCGAAACGGCCACCAC
TGATTTACAAAAAAATCTTGAATTGCTGGAAGAAAAAAACATCGAACTCTCTTTGGATAAAAAGAAAAGCGAGGAGAAAA
GCCGGCAGAAATCTGAATTCATCGCCAACATGAGTCATGAAATACGCACCCCGATGAATGGTATCCTTGGATTTACCAAT
GTCTTGTTAGAAAGCAAGCTGGATTCCTTGCAACAAGAATATGTGAAAACCATTAAATCATCCGCACAAGATCTTCTGGC
AATCATCAATGATATTCTTGACTATTCGAAGATGGACGCCGGTAAATTGCATCTGGATTATATTCCCTTAGACATTCGGG
CTTGCATTGATGACGTCGTTGCCCTGCTTGCTCCGCATGCCCATAAAAAAGGACTTGACCTCATTCCTGCAACCGATATT
GCGGTTCCTAAAACCGTGCTTGGTGACCCATTACGTCTTAAACAAATCATCAGTAATTTGGTCAGCAACGCCATCAAATT
CACCGATCATGGTTATGTGCTTATCCGTACCCATATTGAACAGGAATCAGAAAAAGATTATACCATTTGCCTCGCCATCA
GCGACACAGGCATAGGTATTTGCTCGGAAGATCAAACGACCCTATTTAATGCCTTTAATCAAGCAGATACCACCATCACT
CGTCGCTTCGGCGGCTCAGGTTTAGGATTGGTCATTAGTAAAAAACTTGCCGAACATATGCAGGGACGGATTTCATTAAG
CAGTGAACCGCATAAAGGCTCAACATTTTCAGTGCACATCAAATTAGCAAAGCTTATGGCCTATGAAATAGAAAAGCACC
AAATTCACCGCTTCGGTAATCTTAAAGTTCTCTGCTTTGATGACAATCCTCTGCACCTTGAAGCCCTCTGTAACGGGCTT
GGATATTGGGGCATTCAATGCATTCGTATTGACGCATTCAATCAGTTGGAACAAGCGTTTTATCAACATCAAGACTGCCA
CTTAGCGTTTGTCAGTGTCAATCAAGGCTGTGAACAGCAAGTTGCTGAAGTGTTACGTAAACAATCCATGCCTTGTGTAT
TGGTTTCAAAATGGCCCATTCAGAATTATCAGGCCTTAGGAGCACAGGGCTTTTTATTTAAACCACCTAACATTCAAAAA
CTGCACGAAACCATCGAGCATCTGTTCCATCAATCTTCCATACCAACGTCTGCGGAATCGATGCATATCCAAGAGCTCGA
TACTCTACGTGCCAGATTACGTTTAGCCAAGCCCAATTTACTGGTTGCCGAAGATAATCCAATCAATCGCATGTTGCTCA
ATGCCTTATTGAGTGAAAAAACCTGCATCGATACCGTAGAAGATGGACAACAAGCCGTCACTAAATGCAACAGCAAACGC
TTTCATGCCATTCTTCTCGATTTGCAAATGCCTAAACTTGATGGTTTCGAAGCAGCACGCCTAATTCGGCAACAATCACT
GCTTAATAAAACCACACCCATTATTTTACTGAGTGCCAACAGCATGAATGAAAATAATGAATCCATGCAAAAATTAGGCA
TAGACCTTTGCTTGCAAAAACCTCTGGATGAAGCATCGCTGTTGCGCCATTTGCTGAAAATTATTAATCAAACCACTGCT
TCAGCCATAAATTGGACATTATGCGTGCAAAAAGTCTCGGGTAATCAGGCGTTAGCCACCGAATTTCTTGACCGTTTTGT
TGAGGAATTGCATAAAAATCGCGAAGAACTCTTGCAATTAATGGCCAGTGGACAAATTAAAAACCTGGAAAGAGCCGCTC
ATAAATTGCACGGCGCCTGTTGTTTCTGTGGCGTACCACAATTGCAAAGTCAAGTGGCTCAATTGGAAGCCTTAGCCAAA
CAGGCAAGTCACATCGATGAATTGCAAATGCCATTCAGCCAGTTTATTCAAAGTCTTGATGCTGTGATTGAAGAATATGA
ACATTCTTATCGCGCCCGGGACATTGTGGAGTTGCTTTAA

Domains

Predicted by InterproScan.

• Single cache domain 4 (sCache_4) (36-179)

• Response regulator receiver domain (Response_reg) (681-790)

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (408-523)

• Hpt domain (Hpt) (821-902)

• His Kinase A (phospho-acceptor) domain (HisKA) (297-361)

3D structure

• AlphaFold DB: W0B9F3

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
letS	Legionella pneumophila strain ERS1305867	68.825	99.129	0.682