Detailed information NTG1116737

Bioinformatically predicted

Overview

• Name: ciaH
• Type: Regulator
• Locus tag: EW022_RS04610
• Genome accession: NZ_LR130240
• Coordinates: 895723..897033 (+)
• Length: 436 a.a.
• NCBI ID: WP_011054528.1
• Uniprot ID: A0A4U9BXV0
• Organism: Streptococcus pyogenes strain PS006 isolate PS006
• Function: Required for optimal comC expression (predicted from homology) Competence regulation

Genomic Context

Location: 890723..902033

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EW022_RS04590	phoU	891314..891967 (+)	654	WP_002984514.1	phosphate signaling complex protein PhoU	-
EW022_RS04600	-	892172..894709 (+)	2538	WP_014407610.1	M1 family metallopeptidase	-
EW022_RS04605	ciaR	895056..895730 (+)	675	WP_002984519.1	response regulator transcription factor	Regulator
EW022_RS04610	ciaH	895723..897033 (+)	1311	WP_011054528.1	sensor histidine kinase	Regulator
EW022_RS04615	rpsT	897158..897406 (-)	249	WP_009881183.1	30S ribosomal protein S20	-
EW022_RS04620	coaA	897460..898380 (-)	921	WP_010922353.1	type I pantothenate kinase	-
EW022_RS04625	-	898648..899241 (+)	594	WP_021340920.1	class I SAM-dependent methyltransferase	-
EW022_RS04630	-	899892..900281 (+)	390	WP_002984531.1	cytidine deaminase	-
EW022_RS04635	-	900375..901427 (+)	1053	WP_002989701.1	BMP family lipoprotein	-

Sequence

Protein

• Length: 436 a.a.
• Molecular weight: 50112.66 Da
• Isoelectric Point: 9.2692

>NTDB_id=1116737 EW022_RS04610 WP_011054528.1 895723..897033(+) (ciaH) [Streptococcus pyogenes strain PS006 isolate PS006]
MNKLKKEILSDNYNHFFHFFAVFTGIFVIMTIIILQIMRFGVYSSVDSSLVSVSNNASSYANRTMARISSFYFDTENNII
KALPDSDSSKLLGTPAANTDIILFSANGTILNAFDAFSNYQNFHLDKRRLGSIETTSLMNFYGQEEKYHTITVRVHIKNY
PAVAYMMAVVNVEQLDRANERYERIIIIVMSVFWLISILASIYLAKWSRKPILESYEKQKMFVENASHELRTPLAVLQNR
LESLFRKPNETILENSEHLASSLDEVRNMRILTTNLLNLARRDDGINPQWTHLDTDFFNAIFENYELVAKEYGKIFYFQN
QVNRSLRMDKALLKQLITILFDNAIKYTDKNGIIEIIVKTTDKNLLISVIDNGPGITDEEKKKIFDRFYRVDKARTRQTG
GFGLGLALAQQIVMSLKGNITVKDNDPKGSIFEVKL

Nucleotide

• Length: 1311 bp

>NTDB_id=1116737 EW022_RS04610 WP_011054528.1 895723..897033(+) (ciaH) [Streptococcus pyogenes strain PS006 isolate PS006]
ATGAATAAATTAAAAAAAGAGATTTTATCAGATAACTATAACCACTTTTTTCATTTTTTTGCGGTTTTTACAGGTATTTT
TGTCATTATGACTATTATTATCTTACAGATTATGCGGTTTGGCGTTTATTCGTCAGTTGATAGTAGTTTAGTTTCTGTTA
GTAATAATGCAAGTAGCTATGCTAATCGTACGATGGCTAGAATATCTTCTTTTTACTTTGATACTGAAAATAACATTATT
AAGGCGCTGCCTGATTCAGATAGTTCTAAGTTATTAGGAACGCCTGCAGCTAATACAGATATCATTTTGTTTAGTGCTAA
TGGAACAATTTTAAATGCTTTTGATGCGTTTTCTAACTATCAAAATTTTCATTTAGATAAACGCCGGTTGGGGAGTATTG
AAACCACCAGTTTAATGAATTTTTATGGACAAGAAGAAAAATACCATACGATAACTGTAAGGGTTCATATCAAAAATTAT
CCTGCAGTTGCCTATATGATGGCAGTAGTAAATGTGGAACAATTAGACCGCGCTAATGAACGTTACGAGCGCATTATTAT
TATAGTTATGAGTGTTTTTTGGCTAATTTCTATTTTAGCAAGTATTTATTTAGCCAAGTGGAGCAGAAAACCTATTTTAG
AAAGCTATGAAAAACAAAAAATGTTTGTTGAAAATGCTAGTCATGAACTAAGGACCCCTTTGGCGGTCTTACAGAATCGT
CTGGAATCGCTTTTTCGTAAGCCCAACGAAACGATATTAGAAAATAGTGAGCATCTCGCTTCTAGTTTAGACGAGGTTCG
CAACATGCGCATCTTAACAACTAATTTATTAAATTTAGCAAGACGAGATGATGGCATTAATCCACAGTGGACTCATTTAG
ATACAGATTTTTTTAATGCTATTTTTGAGAATTATGAACTAGTTGCTAAAGAATATGGAAAAATATTTTATTTTCAGAAC
CAAGTCAATAGATCGTTAAGAATGGATAAGGCTTTACTAAAACAATTAATAACGATTTTATTTGACAATGCTATTAAATA
TACAGATAAAAATGGTATTATTGAAATTATAGTGAAAACAACGGACAAAAATTTATTAATTTCTGTTATTGATAATGGTC
CAGGGATAACAGATGAAGAAAAGAAAAAGATTTTTGATCGTTTTTATCGAGTTGACAAAGCTAGAACACGGCAAACAGGT
GGATTTGGCTTGGGGTTGGCTTTAGCTCAGCAAATCGTGATGTCTTTAAAAGGAAATATTACAGTAAAGGATAATGATCC
TAAAGGTAGTATTTTTGAAGTCAAATTATAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (329-436)

• His Kinase A (phospho-acceptor) domain (HisKA) (220-285)

3D structure

• AlphaFold DB: A0A4U9BXV0

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaH	Streptococcus mutans UA159	57.895	100	0.58
ciaH	Streptococcus pneumoniae Rx1	51.37	100	0.516
ciaH	Streptococcus pneumoniae D39	51.37	100	0.516
ciaH	Streptococcus pneumoniae R6	51.37	100	0.516
ciaH	Streptococcus pneumoniae TIGR4	51.37	100	0.516