Detailed information NTG1116505

Bioinformatically predicted

Overview

• Name: ciaH
• Type: Regulator
• Locus tag: EW021_RS04915
• Genome accession: NZ_LR130236
• Coordinates: 953525..954835 (-)
• Length: 436 a.a.
• NCBI ID: WP_047343328.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain 5448 isolate 5448
• Function: Required for optimal comC expression (predicted from homology) Competence regulation

Genomic Context

Location: 948525..959835

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EW021_RS04890	-	949129..950181 (-)	1053	WP_002989701.1	BMP family lipoprotein	-
EW021_RS04895	-	950275..950664 (-)	390	WP_011285547.1	cytidine deaminase	-
EW021_RS04900	-	951323..951910 (-)	588	WP_011285548.1	class I SAM-dependent methyltransferase	-
EW021_RS04905	coaA	952178..953098 (+)	921	WP_010922353.1	type I pantothenate kinase	-
EW021_RS04910	rpsT	953152..953400 (+)	249	WP_009881183.1	30S ribosomal protein S20	-
EW021_RS04915	ciaH	953525..954835 (-)	1311	WP_047343328.1	sensor histidine kinase	Regulator
EW021_RS04920	ciaR	954828..955502 (-)	675	WP_010922355.1	response regulator transcription factor	Regulator
EW021_RS04925	-	955848..958385 (-)	2538	WP_010922356.1	M1 family metallopeptidase	-
EW021_RS04935	phoU	958590..959243 (-)	654	WP_002984514.1	phosphate signaling complex protein PhoU	-

Sequence

Protein

• Length: 436 a.a.
• Molecular weight: 49987.49 Da
• Isoelectric Point: 9.0831

>NTDB_id=1116505 EW021_RS04915 WP_047343328.1 953525..954835(-) (ciaH) [Streptococcus pyogenes strain 5448 isolate 5448]
MNKLKKEILSDNYNHFFHFFAVFTGIFVIMTIIILQIMRFGVYSSVDSSLVSVSNNASSYANRTMARISSFYFDTENNII
KALADSDSSKLLGTPAANTDIILFSANGTILNAFDAFSNYQNFHLDKRRLGSIETTSLMNFYGQEEKYHTITVGVHIKNY
PAVAYMMAVVNVEQLDRANERYERIIIIVMSVFWLISILASIYLAKWSRKPILESYEKQKMFVENASHELRTPLAVLQNR
LESLFRKPNETILENSEHLASSLDEVRNMRILTTNLLNLARRDDGINPQWTHLDTDFFNAIFENYELVAKEYGKIFYFQN
QVNRSLRMDKALLKQLITILFDNAIKYTDKNGIIEIIVKTTDKNLLISVIDNGPGITDEEKKKIFDRFYRVDKARTRQTG
GFGLGLALAQQIVMSLKGNITVKDNDPKGSIFEVKL

Nucleotide

• Length: 1311 bp

>NTDB_id=1116505 EW021_RS04915 WP_047343328.1 953525..954835(-) (ciaH) [Streptococcus pyogenes strain 5448 isolate 5448]
ATGAATAAATTAAAAAAAGAGATTTTATCAGATAACTATAACCACTTTTTTCATTTTTTTGCGGTTTTTACAGGTATTTT
TGTCATTATGACTATTATTATCTTACAGATTATGCGGTTTGGCGTTTATTCGTCAGTTGACAGTAGTTTAGTTTCTGTTA
GTAATAATGCAAGTAGCTATGCTAATCGTACGATGGCTAGAATATCTTCTTTTTACTTTGATACTGAAAATAACATTATT
AAGGCGCTGGCTGATTCAGATAGTTCTAAGTTATTAGGAACGCCTGCAGCTAATACAGATATCATTTTGTTTAGTGCTAA
TGGAACAATTTTAAATGCTTTTGATGCGTTTTCTAACTATCAAAATTTTCATTTAGATAAACGCCGGTTGGGGAGTATTG
AAACCACCAGTTTAATGAATTTTTATGGACAAGAAGAAAAATACCATACGATAACTGTAGGGGTTCATATCAAAAATTAT
CCTGCAGTTGCCTATATGATGGCAGTAGTAAATGTGGAACAATTAGACCGCGCTAATGAACGTTATGAGCGCATTATTAT
TATAGTTATGAGTGTTTTTTGGCTAATTTCTATTTTAGCAAGTATTTATTTAGCCAAGTGGAGCAGAAAACCTATTTTAG
AAAGCTATGAAAAACAAAAAATGTTTGTTGAAAATGCTAGTCATGAATTAAGGACCCCTTTGGCGGTCTTACAGAATCGT
CTGGAATCGCTTTTTCGTAAGCCCAACGAAACGATATTAGAAAATAGTGAGCATCTCGCTTCTAGTTTAGACGAGGTTCG
CAACATGCGCATCTTAACAACTAATTTATTAAATTTAGCAAGACGAGATGATGGCATTAATCCACAGTGGACTCATTTAG
ATACAGATTTTTTTAATGCTATTTTTGAGAATTATGAACTAGTTGCTAAAGAATATGGAAAAATATTTTATTTTCAGAAC
CAAGTCAATAGATCGTTAAGAATGGATAAGGCTTTACTAAAACAATTAATAACGATTTTATTTGACAATGCTATTAAATA
TACAGATAAAAATGGTATTATTGAAATTATAGTGAAAACAACGGACAAAAATTTATTAATTTCTGTTATTGATAATGGTC
CAGGGATAACAGATGAAGAAAAGAAAAAGATTTTTGATCGTTTTTATCGAGTTGACAAAGCTAGAACACGGCAAACAGGT
GGATTTGGCTTGGGGTTGGCTTTAGCTCAGCAAATCGTGATGTCTTTAAAAGGAAATATTACAGTAAAGGATAATGATCC
TAAAGGTAGTATTTTTGAAGTCAAACTATAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (329-436)

• His Kinase A (phospho-acceptor) domain (HisKA) (220-285)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaH	Streptococcus mutans UA159	57.895	100	0.58
ciaH	Streptococcus pneumoniae Rx1	51.598	100	0.518
ciaH	Streptococcus pneumoniae D39	51.598	100	0.518
ciaH	Streptococcus pneumoniae R6	51.598	100	0.518
ciaH	Streptococcus pneumoniae TIGR4	51.598	100	0.518