Detailed information
Bioinformatically predicted
Overview
| Name | vraR | Type | Regulator |
| Locus tag | E0E14_RS10580 | Genome accession | NZ_LR027877 |
| Coordinates | 2044270..2044899 (-) | Length | 209 a.a. |
| NCBI ID | WP_000153530.1 | Uniprot ID | D9IFM7 |
| Organism | Staphylococcus aureus isolate BPH3244 | ||
| Function | repress expression of competence genes (predicted from homology) Competence regulation |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| ICE | 2036981..2078850 | 2044270..2044899 | within | 0 |
Gene organization within MGE regions
Location: 2036981..2078850
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| E0E14_RS10540 | - | 2037191..2038237 (+) | 1047 | WP_001145732.1 | tyrosine-type recombinase/integrase | - |
| E0E14_RS10545 | yfkAB | 2038282..2039427 (+) | 1146 | WP_001245448.1 | radical SAM/CxCxxxxC motif protein YfkAB | - |
| E0E14_RS10550 | - | 2039687..2040217 (-) | 531 | WP_095344333.1 | acyl-CoA thioesterase | - |
| E0E14_RS10555 | - | 2040307..2041563 (-) | 1257 | WP_001795438.1 | aminopeptidase | - |
| E0E14_RS10560 | - | 2041566..2041766 (-) | 201 | WP_000180461.1 | DUF1128 family protein | - |
| E0E14_RS10565 | - | 2041913..2042377 (+) | 465 | WP_000228666.1 | low molecular weight protein-tyrosine-phosphatase | - |
| E0E14_RS10570 | - | 2042384..2042659 (+) | 276 | WP_000428172.1 | YtxH domain-containing protein | - |
| E0E14_RS10575 | - | 2042937..2044154 (+) | 1218 | WP_000037075.1 | YihY/virulence factor BrkB family protein | - |
| E0E14_RS10580 | vraR | 2044270..2044899 (-) | 630 | WP_000153530.1 | two-component system response regulator VraR | Regulator |
| E0E14_RS10585 | vraS | 2044889..2045932 (-) | 1044 | WP_130828154.1 | sensor histidine kinase | Regulator |
| E0E14_RS10590 | liaF | 2045929..2046630 (-) | 702 | WP_000149064.1 | cell wall-active antibiotics response protein LiaF | - |
| E0E14_RS10595 | - | 2046645..2047031 (-) | 387 | WP_001110179.1 | hypothetical protein | - |
| E0E14_RS10600 | map | 2047248..2048006 (-) | 759 | WP_000636142.1 | type I methionyl aminopeptidase | - |
| E0E14_RS10610 | - | 2048593..2049579 (+) | 987 | WP_000999713.1 | FUSC family protein | - |
| E0E14_RS10620 | - | 2050010..2050423 (-) | 414 | WP_001549145.1 | hypothetical protein | - |
| E0E14_RS10625 | - | 2050452..2050562 (-) | 111 | WP_001790257.1 | hypothetical protein | - |
| E0E14_RS10630 | - | 2050648..2051379 (-) | 732 | WP_000544967.1 | type 1 glutamine amidotransferase | - |
| E0E14_RS10635 | murT | 2051381..2052694 (-) | 1314 | WP_001250336.1 | lipid II isoglutaminyl synthase subunit MurT | - |
| E0E14_RS10640 | ftnA | 2052986..2053486 (+) | 501 | WP_000949467.1 | H-type ferritin FtnA | - |
| E0E14_RS10645 | - | 2053845..2054399 (+) | 555 | WP_000613733.1 | 3'-5' exonuclease | - |
| E0E14_RS10650 | dinB | 2054467..2055537 (-) | 1071 | WP_000140176.1 | DNA polymerase IV | - |
| E0E14_RS10655 | - | 2055784..2056314 (-) | 531 | WP_000548781.1 | DUF3267 domain-containing protein | - |
| E0E14_RS10660 | rlmD | 2056484..2057845 (-) | 1362 | WP_001147868.1 | 23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD | - |
| E0E14_RS10665 | - | 2057926..2058873 (-) | 948 | WP_001231451.1 | diacylglycerol kinase | - |
| E0E14_RS10675 | - | 2059456..2059602 (-) | 147 | WP_001797372.1 | hypothetical protein | - |
| E0E14_RS10680 | gatB | 2059642..2061069 (-) | 1428 | WP_000545370.1 | Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB | - |
| E0E14_RS10685 | gatA | 2061082..2062539 (-) | 1458 | WP_000027928.1 | Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatA | - |
| E0E14_RS10690 | gatC | 2062541..2062843 (-) | 303 | WP_000170162.1 | Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC | - |
| E0E14_RS10695 | putP | 2063210..2064748 (+) | 1539 | WP_000957015.1 | sodium/proline symporter PutP | - |
| E0E14_RS10700 | - | 2064837..2066036 (-) | 1200 | WP_000831698.1 | CamS family sex pheromone protein | - |
| E0E14_RS10705 | ligA | 2066049..2068052 (-) | 2004 | WP_000774565.1 | NAD-dependent DNA ligase LigA | - |
| E0E14_RS10710 | pcrA | 2068056..2070248 (-) | 2193 | WP_000992921.1 | DNA helicase PcrA | - |
| E0E14_RS10715 | - | 2070245..2070937 (-) | 693 | WP_000272068.1 | heptaprenylglyceryl phosphate synthase | - |
| E0E14_RS10720 | - | 2071109..2071411 (-) | 303 | WP_001165363.1 | YerC/YecD family TrpR-related protein | - |
| E0E14_RS10725 | purB | 2071520..2072815 (-) | 1296 | WP_000572878.1 | adenylosuccinate lyase | - |
| E0E14_RS10735 | scpA | 2073676..2074842 (+) | 1167 | WP_000827748.1 | cysteine protease staphopain A | - |
| E0E14_RS10740 | - | 2074873..2075199 (+) | 327 | WP_000434933.1 | staphostatin A | - |
| E0E14_RS10745 | - | 2075491..2075664 (-) | 174 | WP_000669862.1 | NETI motif-containing protein | - |
| E0E14_RS10750 | - | 2075645..2076247 (-) | 603 | WP_000011542.1 | DUF2179 domain-containing protein | - |
| E0E14_RS10755 | nadE | 2076518..2077339 (-) | 822 | WP_000040873.1 | ammonia-dependent NAD(+) synthetase | - |
| E0E14_RS10760 | - | 2077332..2078801 (-) | 1470 | WP_000284431.1 | nicotinate phosphoribosyltransferase | - |
Sequence
Protein
Download Length: 209 a.a. Molecular weight: 23545.29 Da Isoelectric Point: 5.3889
>NTDB_id=1116016 E0E14_RS10580 WP_000153530.1 2044270..2044899(-) (vraR) [Staphylococcus aureus isolate BPH3244]
MTIKVLFVDDHEMVRIGISSYLSTQSDIEVVGEGASGKEAIAKAHELKPDLILMDLLMDDMDGVEATTQIKKDLPQIKVL
MLTSFIEDKEVYRALDAGVDSYILKTTSAKDIADAVRKTSRGESVFEPEVLVKMRNRMKKRAELYEMLTEREMEILLLIA
KGYSNQEIASASHITIKTVKTHVSNILSKLEVQDRTQAVIYAFQHNLIQ
MTIKVLFVDDHEMVRIGISSYLSTQSDIEVVGEGASGKEAIAKAHELKPDLILMDLLMDDMDGVEATTQIKKDLPQIKVL
MLTSFIEDKEVYRALDAGVDSYILKTTSAKDIADAVRKTSRGESVFEPEVLVKMRNRMKKRAELYEMLTEREMEILLLIA
KGYSNQEIASASHITIKTVKTHVSNILSKLEVQDRTQAVIYAFQHNLIQ
Nucleotide
Download Length: 630 bp
>NTDB_id=1116016 E0E14_RS10580 WP_000153530.1 2044270..2044899(-) (vraR) [Staphylococcus aureus isolate BPH3244]
ATGACGATTAAAGTATTGTTTGTGGATGATCATGAAATGGTACGTATAGGAATTTCAAGTTATCTATCAACGCAAAGTGA
TATTGAAGTAGTTGGTGAAGGCGCTTCTGGTAAAGAAGCAATTGCCAAAGCCCATGAGTTGAAGCCAGATTTAATTTTAA
TGGATTTACTTATGGATGACATGGATGGTGTAGAAGCGACGACTCAGATTAAAAAAGATTTACCGCAAATTAAAGTATTA
ATGTTAACTAGTTTTATTGAAGATAAAGAGGTATATCGTGCATTAGATGCAGGTGTCGATAGTTACATTTTAAAAACAAC
AAGTGCAAAAGATATCGCCGATGCAGTTCGTAAAACTTCTAGAGGAGAATCTGTTTTTGAACCGGAAGTTTTAGTGAAAA
TGCGTAACCGTATGAAAAAGCGCGCAGAGTTATATGAAATGCTTACAGAACGAGAAATGGAAATATTATTATTGATTGCG
AAAGGTTACTCAAATCAAGAAATTGCTAGTGCATCGCATATTACTATTAAAACGGTTAAGACACATGTGAGTAACATTTT
AAGTAAGTTAGAAGTGCAAGATAGAACACAAGCTGTTATCTATGCATTCCAACATAATTTAATTCAATAG
ATGACGATTAAAGTATTGTTTGTGGATGATCATGAAATGGTACGTATAGGAATTTCAAGTTATCTATCAACGCAAAGTGA
TATTGAAGTAGTTGGTGAAGGCGCTTCTGGTAAAGAAGCAATTGCCAAAGCCCATGAGTTGAAGCCAGATTTAATTTTAA
TGGATTTACTTATGGATGACATGGATGGTGTAGAAGCGACGACTCAGATTAAAAAAGATTTACCGCAAATTAAAGTATTA
ATGTTAACTAGTTTTATTGAAGATAAAGAGGTATATCGTGCATTAGATGCAGGTGTCGATAGTTACATTTTAAAAACAAC
AAGTGCAAAAGATATCGCCGATGCAGTTCGTAAAACTTCTAGAGGAGAATCTGTTTTTGAACCGGAAGTTTTAGTGAAAA
TGCGTAACCGTATGAAAAAGCGCGCAGAGTTATATGAAATGCTTACAGAACGAGAAATGGAAATATTATTATTGATTGCG
AAAGGTTACTCAAATCAAGAAATTGCTAGTGCATCGCATATTACTATTAAAACGGTTAAGACACATGTGAGTAACATTTT
AAGTAAGTTAGAAGTGCAAGATAGAACACAAGCTGTTATCTATGCATTCCAACATAATTTAATTCAATAG
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| vraR | Staphylococcus aureus N315 |
99.522 |
100 |
0.995 |
| degU | Bacillus subtilis subsp. subtilis str. 168 |
34.821 |
100 |
0.373 |