Detailed information NTG1091877

Bioinformatically predicted

Overview

• Name: agrA
• Type: Regulator
• Locus tag: ACLZHS_RS04090
• Genome accession: NZ_CP178841
• Coordinates: 882659..883375 (-)
• Length: 238 a.a.
• NCBI ID: WP_001829999.1
• Uniprot ID: C0LF82
• Organism: Staphylococcus epidermidis strain HE23
• Function: promote expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 877659..888375

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACLZHS_RS04075	-	878940..879893 (+)	954	WP_001830022.1	LacI family DNA-binding transcriptional regulator	-
ACLZHS_RS04080	-	880153..881625 (+)	1473	WP_001830011.1	sucrose-6-phosphate hydrolase	-
ACLZHS_RS04085	-	881632..882591 (+)	960	WP_002485130.1	carbohydrate kinase family protein	-
ACLZHS_RS04090	agrA	882659..883375 (-)	717	WP_001829999.1	quorum-sensing response regulator AgrA	Regulator
ACLZHS_RS04095	agrC	883392..884681 (-)	1290	WP_010959211.1	quorum-sensing sensor histidine kinase AgrC	-
ACLZHS_RS04100	agrD	884708..884848 (-)	141	WP_001830021.1	cyclic lactone autoinducer peptide AgrD	-
ACLZHS_RS04105	-	884832..885416 (-)	585	WP_002489905.1	accessory gene regulator AgrB	-
ACLZHS_RS04110	hld	885733..885810 (+)	78	WP_002494082.1	delta-hemolysin	-
ACLZHS_RS04115	-	886191..886976 (-)	786	WP_002469371.1	carbon-nitrogen family hydrolase	-

Sequence

Protein

• Length: 238 a.a.
• Molecular weight: 27936.97 Da
• Isoelectric Point: 5.6250

>NTDB_id=1091877 ACLZHS_RS04090 WP_001829999.1 882659..883375(-) (agrA) [Staphylococcus epidermidis strain HE23]
MKIFVCEDDQRQREHMVSIIKNYIMIEEKPMELALATNDPYEVLEQSKELNDIGCYFLDIQLEADMNGIKLASEIRKHDP
VGNIIFVTSHSELTYLTFVYKVAAMDFIFKDDPSELKMRIIDCLETAHTRLKLLSKESNVDTIELKRGSNSVYVQYDDIM
FFESSTKSHRLIAHLDNRQIEFYGNLKELAQLDERFFRCHNSFVINRHNIESIDSKERIVYFKNGENCFASVRNVKKI

Nucleotide

• Length: 717 bp

>NTDB_id=1091877 ACLZHS_RS04090 WP_001829999.1 882659..883375(-) (agrA) [Staphylococcus epidermidis strain HE23]
ATGAAAATTTTTGTTTGTGAAGATGACCAAAGACAAAGAGAACATATGGTATCAATCATTAAAAACTACATAATGATTGA
AGAAAAGCCAATGGAGTTAGCTTTAGCAACAAATGATCCTTATGAGGTCTTAGAGCAATCAAAAGAACTTAATGACATTG
GTTGTTACTTCCTTGATATTCAATTAGAAGCTGATATGAACGGTATTAAATTAGCCAGTGAAATTCGTAAACATGATCCT
GTTGGTAATATTATATTTGTAACCAGTCACAGTGAGCTGACTTATTTGACGTTTGTTTATAAAGTGGCTGCTATGGATTT
TATTTTTAAAGATGATCCATCTGAATTAAAAATGAGAATCATAGATTGTCTTGAAACAGCACATACACGACTCAAATTAT
TATCAAAAGAAAGTAATGTAGATACGATTGAGTTAAAGCGGGGAAGTAATTCAGTATACGTTCAATATGATGATATTATG
TTTTTTGAATCATCTACGAAATCTCATAGACTCATTGCACATCTTGATAATCGACAAATTGAATTTTATGGAAATTTAAA
GGAATTAGCACAGCTTGATGAACGTTTCTTTAGATGTCATAACAGTTTTGTAATAAACAGGCATAATATTGAATCTATTG
ACTCAAAAGAACGTATTGTTTACTTTAAGAATGGCGAAAATTGTTTCGCTTCAGTACGTAATGTTAAAAAAATATAA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-237)

• Response regulator receiver domain (Response_reg) (3-120)

3D structure

• AlphaFold DB: C0LF82

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
agrA	Staphylococcus aureus N315	87.815	100	0.878
comE/comE2	Streptococcus gordonii strain NCTC7865	35.178	100	0.374
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	35.178	100	0.374