Detailed information    

insolico Bioinformatically predicted

Overview

Name   micB   Type   Regulator
Locus tag   ACAM23_RS06270 Genome accession   NZ_AP031394
Coordinates   1208904..1210253 (-) Length   449 a.a.
NCBI ID   WP_000886210.1    Uniprot ID   A0A064BZM9
Organism   Streptococcus pneumoniae strain 16P28     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 1203904..1215253
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ACAM23_RS06245 (SPNE16P28_12210) - 1205439..1206425 (+) 987 WP_000204727.1 L-lactate dehydrogenase -
  ACAM23_RS06250 (SPNE16P28_12220) - 1206681..1207457 (-) 777 WP_000731138.1 potassium channel family protein -
  ACAM23_RS06255 (SPNE16P28_12230) - 1207504..1207758 (-) 255 WP_001809704.1 type II toxin-antitoxin system RelE/ParE family toxin -
  ACAM23_RS06260 (SPNE16P28_12240) relB 1207760..1208002 (-) 243 WP_000208080.1 type II toxin-antitoxin system RelB family antitoxin -
  ACAM23_RS06265 (SPNE16P28_12250) vicX 1208093..1208902 (-) 810 WP_001289493.1 MBL fold metallo-hydrolase Regulator
  ACAM23_RS06270 (SPNE16P28_12260) micB 1208904..1210253 (-) 1350 WP_000886210.1 cell wall metabolism sensor histidine kinase VicK Regulator
  ACAM23_RS06275 (SPNE16P28_12270) micA 1210246..1210950 (-) 705 WP_000722076.1 response regulator YycF Regulator
  ACAM23_RS06280 (SPNE16P28_12280) mutY 1211005..1212180 (-) 1176 WP_000886145.1 A/G-specific adenine glycosylase -
  ACAM23_RS06285 - 1212277..1212402 (+) 126 WP_001818232.1 hypothetical protein -
  ACAM23_RS06290 (SPNE16P28_12290) - 1212508..1214178 (-) 1671 WP_000845279.1 formate--tetrahydrofolate ligase -
  ACAM23_RS06295 (SPNE16P28_12300) coaB 1214408..1215097 (+) 690 WP_000699499.1 phosphopantothenate--cysteine ligase -

Sequence

Protein


Download         Length: 449 a.a.        Molecular weight: 51712.42 Da        Isoelectric Point: 4.9706

>NTDB_id=108964 ACAM23_RS06270 WP_000886210.1 1208904..1210253(-) (micB) [Streptococcus pneumoniae strain 16P28]
MLDLLKQTIFTRDFIFILILLGFILVVTLLLLENRRDNIQLKQINQKVKDLIAGDYSKVLDMQGGSEITNITNNLNDLSE
VIRLTQENLEQESKRLNSILFYMTDGVLATNRRGQIIMINDTAKKQLGLVKEDVLNRSILELLKIEENYELRDLITQSPE
LLLDSQDINGEYLNLRVRFALIRRESGFISGLVAVLHDTTEQEKEERERRLFVSNVSHELRTPLTSVKSYLEALDEGALC
ETVAPDFIKVSLDETNRMMRMVTDLLHLSRIDNATSHLDVELINFTAFITFILNRFDKMKGQEKEKKYELVRDYPINSIW
MEIDTDKMTQVVDNILNNAIKYSPDGGKITVRMKTTEDQMILSISDHGLGIPKQDLPRIFDRFYRVDRARSRAQGGTGLG
LSIAKEIIKQHKGFIWAKSEYGKGSTFTIVLPYDKDAVKEEVWEDEVED

Nucleotide


Download         Length: 1350 bp        

>NTDB_id=108964 ACAM23_RS06270 WP_000886210.1 1208904..1210253(-) (micB) [Streptococcus pneumoniae strain 16P28]
ATGCTTGATTTACTGAAACAAACCATTTTTACCAGAGATTTTATCTTTATCCTGATTTTGTTAGGTTTCATCCTTGTTGT
GACCCTCTTATTACTGGAAAATAGACGTGATAATATTCAGTTGAAGCAAATCAATCAAAAGGTTAAAGATTTGATTGCAG
GAGATTATTCCAAGGTTCTTGATATGCAAGGTGGGTCTGAAATCACCAATATTACCAATAATTTGAATGACTTGTCGGAG
GTTATTCGTCTCACTCAGGAAAATCTAGAACAAGAGAGTAAGAGGCTAAATAGTATTCTGTTTTATATGACAGATGGGGT
TCTTGCGACCAACCGTCGGGGTCAGATTATCATGATTAACGATACAGCCAAGAAGCAACTGGGGTTGGTTAAGGAAGATG
TTCTGAATAGAAGCATTTTGGAATTGCTCAAGATAGAAGAAAACTATGAATTGCGTGATTTGATTACCCAAAGTCCAGAA
TTGTTGCTAGATTCCCAAGATATCAATGGCGAATATTTGAACCTTCGAGTTCGCTTTGCCTTGATACGTCGAGAGTCTGG
CTTTATTTCAGGTTTGGTGGCTGTTTTGCATGATACGACGGAGCAGGAGAAGGAAGAACGCGAACGAAGACTCTTTGTTT
CCAATGTTAGCCATGAGTTACGGACTCCTCTGACTAGCGTAAAATCCTATCTTGAAGCCTTGGATGAGGGGGCTTTGTGT
GAAACTGTAGCACCAGACTTTATCAAGGTTTCTCTTGATGAAACCAACCGTATGATGCGCATGGTGACGGATCTCCTCCA
TCTTTCACGTATTGATAATGCTACCAGTCATCTAGATGTGGAACTGATTAACTTCACTGCTTTTATTACCTTTATCCTCA
ATCGTTTTGACAAGATGAAAGGACAGGAAAAGGAAAAAAAATATGAGTTGGTGAGAGATTATCCCATCAATTCTATCTGG
ATGGAAATTGATACAGATAAGATGACGCAGGTTGTCGACAATATTTTAAATAATGCTATTAAGTATTCGCCAGATGGGGG
TAAAATCACTGTCAGAATGAAGACAACTGAAGACCAGATGATTTTATCCATTTCTGACCACGGTTTGGGGATTCCTAAGC
AGGATTTACCACGTATCTTTGACCGTTTCTATCGTGTGGATCGTGCTAGAAGTCGTGCACAAGGTGGTACAGGTCTAGGA
CTGTCTATCGCTAAAGAAATTATCAAACAACATAAGGGCTTTATTTGGGCCAAGAGTGAATACGGCAAGGGTTCAACCTT
TACCATTGTGCTCCCTTATGATAAGGATGCAGTGAAAGAAGAAGTATGGGAGGATGAAGTAGAAGACTAG

Domains

Predicted by InterproScan.

PAS fold (PAS)

(98-198)

His Kinase A (phospho-acceptor) domain (HisKA)

(209-273)

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(324-434)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A064BZM9

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  micB Streptococcus pneumoniae Cp1015

99.777

100

0.998
  vicK Streptococcus mutans UA159

69.9

89.532

0.626

Multiple sequence alignment