Detailed information NTG0108965

Bioinformatically predicted

Overview

• Name: micA
• Type: Regulator
• Locus tag: ACAM23_RS06275
• Genome accession: NZ_AP031394
• Coordinates: 1210246..1210950 (-)
• Length: 234 a.a.
• NCBI ID: WP_000722076.1
• Uniprot ID: Q9S1K0
• Organism: Streptococcus pneumoniae strain 16P28
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 1205246..1215950

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACAM23_RS06245 (SPNE16P28_12210)	-	1205439..1206425 (+)	987	WP_000204727.1	L-lactate dehydrogenase	-
ACAM23_RS06250 (SPNE16P28_12220)	-	1206681..1207457 (-)	777	WP_000731138.1	potassium channel family protein	-
ACAM23_RS06255 (SPNE16P28_12230)	-	1207504..1207758 (-)	255	WP_001809704.1	type II toxin-antitoxin system RelE/ParE family toxin	-
ACAM23_RS06260 (SPNE16P28_12240)	relB	1207760..1208002 (-)	243	WP_000208080.1	type II toxin-antitoxin system RelB family antitoxin	-
ACAM23_RS06265 (SPNE16P28_12250)	vicX	1208093..1208902 (-)	810	WP_001289493.1	MBL fold metallo-hydrolase	Regulator
ACAM23_RS06270 (SPNE16P28_12260)	micB	1208904..1210253 (-)	1350	WP_000886210.1	cell wall metabolism sensor histidine kinase VicK	Regulator
ACAM23_RS06275 (SPNE16P28_12270)	micA	1210246..1210950 (-)	705	WP_000722076.1	response regulator YycF	Regulator
ACAM23_RS06280 (SPNE16P28_12280)	mutY	1211005..1212180 (-)	1176	WP_000886145.1	A/G-specific adenine glycosylase	-
ACAM23_RS06285	-	1212277..1212402 (+)	126	WP_001818232.1	hypothetical protein	-
ACAM23_RS06290 (SPNE16P28_12290)	-	1212508..1214178 (-)	1671	WP_000845279.1	formate--tetrahydrofolate ligase	-
ACAM23_RS06295 (SPNE16P28_12300)	coaB	1214408..1215097 (+)	690	WP_000699499.1	phosphopantothenate--cysteine ligase	-
ACAM23_RS06300 (SPNE16P28_12310)	coaC	1215109..1215660 (+)	552	WP_001284124.1	phosphopantothenoylcysteine decarboxylase	-

Sequence

Protein

• Length: 234 a.a.
• Molecular weight: 26815.63 Da
• Isoelectric Point: 4.7164

>NTDB_id=108965 ACAM23_RS06275 WP_000722076.1 1210246..1210950(-) (micA) [Streptococcus pneumoniae strain 16P28]
MKKILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSSVPILMLSA
KDSEFDKVIGLELGADDYVTKPFSNRELQARVKALLRRSQPMPVDGQEADSKPQPIQIGDLEIVPDAYVAKKYGEELDLT
HREFELLYHLASHTGQVITREHLLETVWGYDYFGDVRTVDVTVRRLREKIEDTPSRPEYILTRRGVGYYMRNNA

Nucleotide

• Length: 705 bp

>NTDB_id=108965 ACAM23_RS06275 WP_000722076.1 1210246..1210950(-) (micA) [Streptococcus pneumoniae strain 16P28]
ATGAAAAAAATACTAATTGTAGATGATGAGAAACCAATCTCGGATATTATCAAGTTTAATATGACCAAGGAAGGTTACGA
AGTTGTAACTGCTTTTAATGGTCGTGAAGCGCTAGAGCAATTTGAAGCAGAGCAACCAGATATTATTATTCTGGATTTGA
TGCTTCCAGAAATTGATGGTTTAGAAGTTGCTAAGACCATTCGTAAGACAAGCAGTGTGCCCATTCTTATGCTTTCAGCC
AAAGATAGTGAATTTGATAAGGTTATCGGTTTGGAACTTGGGGCAGATGACTATGTAACGAAACCCTTCTCCAATCGTGA
GTTGCAGGCGCGTGTTAAAGCTCTTCTGCGTCGTTCTCAACCTATGCCAGTAGATGGTCAGGAAGCAGATAGTAAACCTC
AACCTATCCAAATTGGGGATTTAGAAATTGTTCCAGACGCCTACGTGGCTAAAAAATATGGCGAAGAACTAGACTTAACC
CATCGTGAATTTGAGCTTTTGTATCATTTAGCATCGCATACAGGTCAAGTCATCACGCGCGAACACTTGCTTGAGACTGT
CTGGGGTTATGACTATTTTGGTGATGTCCGCACAGTTGATGTGACTGTACGACGTCTGCGTGAGAAGATTGAAGATACGC
CCAGCCGACCAGAGTATATCTTGACGCGCCGTGGTGTAGGGTATTACATGAGAAATAATGCTTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (4-112)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (154-229)

3D structure

• PDB: 1NXS
• PDB: 2A9O
• PDB: 2A9P

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
micA	Streptococcus pneumoniae Cp1015	100	100	1
vicR	Streptococcus mutans UA159	78.541	99.573	0.782
covR	Streptococcus salivarius strain HSISS4	44.156	98.718	0.436
covR	Lactococcus lactis subsp. lactis strain DGCC12653	43.478	98.291	0.427
scnR	Streptococcus mutans UA159	38.197	99.573	0.38