Detailed information NTG1086025

Bioinformatically predicted

Overview

• Name: comEA
• Type: Machinery gene
• Locus tag: ACJWMD_RS07920
• Genome accession: NZ_CP177182
• Coordinates: 1682001..1682696 (-)
• Length: 231 a.a.
• NCBI ID: WP_004183181.1
• Uniprot ID: -
• Organism: Streptococcus salivarius strain MRD6060
• Function: dsDNA binding to the cell surface (predicted from homology) DNA binding and uptake

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
ICE	1669335..1686040	1682001..1682696	within	0

Gene organization within MGE regions

Location: 1669335..1686040

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACJWMD_RS07875	-	1671359..1672126 (+)	768	WP_004183166.1	replication-relaxation family protein	-
ACJWMD_RS07880	-	1672302..1673969 (+)	1668	WP_004183168.1	recombinase family protein	-
ACJWMD_RS07885	-	1674078..1674587 (-)	510	WP_004183169.1	QueT transporter family protein	-
ACJWMD_RS07890	-	1674678..1675637 (-)	960	WP_004183170.1	YihY/virulence factor BrkB family protein	-
ACJWMD_RS07895	-	1675639..1676499 (-)	861	WP_004183173.1	methionyl aminopeptidase	-
ACJWMD_RS07900	spxR	1676539..1677819 (-)	1281	WP_004183175.1	CBS-HotDog domain-containing transcription factor SpxR	-
ACJWMD_RS07905	-	1677812..1678357 (-)	546	WP_004183177.1	GNAT family N-acetyltransferase	-
ACJWMD_RS07910	-	1678423..1679685 (-)	1263	WP_004183178.1	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	-
ACJWMD_RS07915	-	1679771..1682011 (-)	2241	WP_004183180.1	DNA internalization-related competence protein ComEC/Rec2	-
ACJWMD_RS07920	comEA	1682001..1682696 (-)	696	WP_004183181.1	helix-hairpin-helix domain-containing protein	Machinery gene
ACJWMD_RS07925	-	1682805..1683560 (-)	756	WP_004183182.1	lysophospholipid acyltransferase family protein	-
ACJWMD_RS07930	-	1683690..1684625 (+)	936	WP_037605714.1	polysaccharide deacetylase family protein	-
ACJWMD_RS07935	-	1684675..1685439 (+)	765	WP_004183185.1	tRNA1(Val) (adenine(37)-N6)-methyltransferase	-
ACJWMD_RS07940	-	1685443..1685712 (+)	270	WP_004183187.1	GIY-YIG nuclease family protein	-

Sequence

Protein

• Length: 231 a.a.
• Molecular weight: 24284.10 Da
• Isoelectric Point: 4.5517

>NTDB_id=1086025 ACJWMD_RS07920 WP_004183181.1 1682001..1682696(-) (comEA) [Streptococcus salivarius strain MRD6060]
MKEKILAYVKDNCLFVSVIAVLMVIFCFFLWMTYGAGNSMEAETSYTDVTALSTSSSKQSSQSLSEASSQSKTEGSEKGE
SKVTVDVKGAVANPGVYTLKASARVTDAIKAAGGMTEDADAKSVNLAASLSDEEVVYVATKDENLSVLGQSGTGQVSDKG
GQTSAKDGKINLNTATSEELQTISGIGAKRAEDIIAYRESHGGFQSVDDLKNVSGIGDKTLDKIRESLYVA

Nucleotide

• Length: 696 bp

>NTDB_id=1086025 ACJWMD_RS07920 WP_004183181.1 1682001..1682696(-) (comEA) [Streptococcus salivarius strain MRD6060]
GTGAAGGAAAAGATTCTAGCCTATGTCAAAGATAATTGTCTGTTTGTGAGTGTTATTGCTGTACTGATGGTGATTTTTTG
CTTCTTCCTATGGATGACTTACGGTGCCGGCAACAGCATGGAGGCGGAGACGTCTTATACAGATGTGACAGCTTTGTCAA
CCTCCTCCTCCAAACAAAGCTCACAGTCTCTTTCTGAGGCGTCTTCCCAGTCAAAGACTGAAGGAAGTGAAAAGGGTGAG
TCAAAAGTAACGGTAGATGTTAAGGGGGCTGTGGCTAATCCGGGTGTTTATACCTTAAAAGCAAGCGCTAGGGTGACTGA
TGCCATCAAAGCCGCTGGGGGAATGACTGAGGATGCGGATGCTAAGAGTGTTAACTTAGCTGCAAGCTTGTCAGACGAAG
AGGTTGTCTATGTGGCAACTAAGGATGAAAACCTCTCTGTTCTTGGTCAATCAGGAACTGGTCAGGTCTCTGACAAAGGA
GGGCAAACTAGTGCTAAGGATGGCAAAATCAACTTAAACACAGCGACTTCAGAGGAGTTGCAAACCATTTCTGGGATTGG
AGCTAAGCGTGCTGAGGATATCATTGCCTATCGTGAAAGTCATGGTGGCTTTCAATCCGTAGATGACTTGAAAAATGTCT
CAGGAATTGGTGATAAAACTTTAGATAAAATCAGAGAGTCCCTCTATGTGGCTTAA

Domains

Predicted by InterproScan.

• SLBB domain (SLBB) (85-138)

• Helix-hairpin-helix motif (HHH_3) (168-228)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comEA	Streptococcus thermophilus LMD-9	91.775	100	0.918
comEA/celA/cilE	Streptococcus mitis SK321	41.048	99.134	0.407
comEA/celA/cilE	Streptococcus pneumoniae TIGR4	40.611	99.134	0.403