Detailed information NTG0107328

Bioinformatically predicted

Overview

• Name: micB
• Type: Regulator
• Locus tag: ACAM22_RS05545
• Genome accession: NZ_AP028929
• Coordinates: 1249783..1251132 (-)
• Length: 449 a.a.
• NCBI ID: WP_101785034.1
• Uniprot ID: -
• Organism: Streptococcus sp. SN-1
• Function: repress competence development (predicted from homology) Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
Genomic island	1232913..1248885	1249783..1251132	flank	898

Gene organization within MGE regions

Location: 1232913..1251132

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACAM22_RS05430 (MASAN616_10690)	-	1232913..1234127 (-)	1215	WP_369606484.1	MFS transporter	-
ACAM22_RS05435 (MASAN616_10700)	-	1234280..1235146 (-)	867	WP_369606485.1	helix-turn-helix domain-containing protein	-
ACAM22_RS05445 (MASAN616_10710)	rplS	1235925..1236272 (-)	348	WP_001068669.1	50S ribosomal protein L19	-
ACAM22_RS05450 (MASAN616_10720)	crcB	1236391..1236720 (-)	330	WP_369606486.1	fluoride efflux transporter CrcB	-
ACAM22_RS05455 (MASAN616_10730)	crcB	1236714..1237088 (-)	375	WP_369606487.1	fluoride efflux transporter CrcB	-
ACAM22_RS05460 (MASAN616_10740)	-	1237085..1237351 (-)	267	WP_101782013.1	chorismate mutase	-
ACAM22_RS05465 (MASAN616_10750)	-	1237467..1237910 (-)	444	WP_001162128.1	flavodoxin	-
ACAM22_RS05470 (MASAN616_10760)	-	1238014..1238949 (+)	936	WP_369606488.1	bifunctional oligoribonuclease/PAP phosphatase NrnA	-
ACAM22_RS05475 (MASAN616_10770)	-	1239045..1239287 (+)	243	WP_000710764.1	type B 50S ribosomal protein L31	-
ACAM22_RS05480 (MASAN616_10780)	-	1239392..1240549 (-)	1158	WP_261050019.1	site-specific integrase	-
ACAM22_RS05485 (MASAN616_10790)	-	1240614..1241180 (-)	567	WP_261050021.1	helix-turn-helix transcriptional regulator	-
ACAM22_RS05490 (MASAN616_10800)	-	1241333..1241611 (+)	279	WP_261050022.1	DNA-binding protein	-
ACAM22_RS05495 (MASAN616_10810)	-	1241617..1241946 (+)	330	WP_261050024.1	replication initiator protein A	-
ACAM22_RS05500 (MASAN616_10820)	-	1241949..1242608 (+)	660	WP_261050026.1	hypothetical protein	-
ACAM22_RS05505 (MASAN616_10830)	-	1242895..1243740 (+)	846	WP_261050028.1	replication initiation factor domain-containing protein	-
ACAM22_RS05510 (MASAN616_10840)	mobV	1244023..1245492 (+)	1470	WP_261050035.1	MobV family relaxase	-
ACAM22_RS05515 (MASAN616_10850)	-	1246286..1246570 (+)	285	WP_218774794.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	-
ACAM22_RS05520 (MASAN616_10860)	-	1246560..1246919 (+)	360	WP_261029296.1	type II toxin-antitoxin system RelE/ParE family toxin	-
ACAM22_RS05525 (MASAN616_10870)	-	1247073..1247517 (-)	445	Protein_1095	imelysin family protein	-
ACAM22_RS05530 (MASAN616_10880)	-	1247703..1248002 (+)	300	WP_000981526.1	YbaB/EbfC family nucleoid-associated protein	-
ACAM22_RS05535 (MASAN616_10890)	-	1248112..1248885 (-)	774	WP_285300906.1	ion channel	-
ACAM22_RS05540 (MASAN616_10900)	vicX	1248972..1249781 (-)	810	WP_000004961.1	MBL fold metallo-hydrolase	Regulator
ACAM22_RS05545 (MASAN616_10910)	micB	1249783..1251132 (-)	1350	WP_101785034.1	cell wall metabolism sensor histidine kinase VicK	Regulator

Sequence

Protein

• Length: 449 a.a.
• Molecular weight: 51452.95 Da
• Isoelectric Point: 4.7585

>NTDB_id=107328 ACAM22_RS05545 WP_101785034.1 1249783..1251132(-) (micB) [Streptococcus sp. SN-1]
MIKLIKDTVLTSDFIFILILLGFILVVTLLLLENRRDNIRLKQINQKVKDLIAGDYSQVLDMQGSSEITNITNNLNDLSE
VIRLTQENLEQESKRLHSILSYMTDGVLATNRRGKITMINDMAKKQLGVQKEDVLNKSILELLKIEDEYELRDLITQIPE
LIIDSQDANGEYLSLRVRFALIRRESGFISGLVAVLHDTTEQEKEERERRLFVSNVSHELRTPLTSVKSYLEALDEGALC
ETVAPDFIKVSLDETNRMMRMVTDLLHLSRIDNATSHLDVELINFTAFITFILNRFDQIRGQDEEKKYDLVRDYPITSVW
IEIDTDKMTQVIDNILNNAIKYSPDGGKITVTMKTTDDQMILSISDQGLGIPKQDLPRIFDRFYRVDRARSRAQGGTGLG
LSIAKEIIKQHKGFIWAKSEYGKGSTFTIVLPYDKDAVKEEVWEDEVED

Nucleotide

• Length: 1350 bp

>NTDB_id=107328 ACAM22_RS05545 WP_101785034.1 1249783..1251132(-) (micB) [Streptococcus sp. SN-1]
ATGATTAAACTAATTAAAGATACAGTTTTAACCAGTGATTTTATCTTTATCCTCATTCTACTTGGCTTTATTTTAGTGGT
GACCTTGCTCTTACTAGAAAATCGTCGGGATAATATTCGGTTGAAGCAAATCAATCAAAAGGTAAAAGACCTGATTGCAG
GAGATTATTCTCAGGTATTGGATATGCAGGGAAGCTCTGAAATCACCAATATTACTAATAATCTCAATGATTTATCAGAA
GTAATTCGTTTAACCCAAGAAAATCTGGAACAAGAGAGTAAACGATTACATAGTATCCTATCTTACATGACCGACGGAGT
CCTTGCGACCAATCGTCGTGGTAAGATTACTATGATTAATGACATGGCTAAGAAACAGTTAGGTGTTCAGAAAGAAGATG
TTCTTAACAAGAGTATCCTAGAGTTACTTAAGATTGAAGATGAGTATGAACTTCGTGATTTGATTACCCAAATTCCTGAG
CTCATCATTGATTCTCAGGATGCTAATGGTGAGTATCTAAGCCTCCGTGTTCGCTTTGCCTTGATTCGTCGAGAGTCTGG
CTTTATTTCGGGTCTGGTTGCTGTTTTGCATGATACGACGGAGCAGGAGAAGGAAGAACGCGAACGGAGGCTCTTTGTTT
CCAACGTTAGTCATGAGCTACGTACTCCTCTAACTAGTGTGAAATCTTATCTTGAAGCCTTGGATGAGGGGGCTTTGTGT
GAAACTGTAGCACCAGACTTTATCAAGGTATCTCTAGATGAAACCAACCGTATGATGCGAATGGTGACGGATCTCCTCCA
TCTCTCACGGATTGATAATGCGACCAGTCACCTAGATGTGGAACTGATTAACTTTACTGCCTTTATTACTTTTATCCTCA
ACCGTTTTGATCAGATAAGAGGGCAGGATGAAGAGAAAAAATATGATTTGGTAAGGGATTATCCAATTACCTCTGTCTGG
ATTGAAATTGATACAGATAAGATGACACAGGTGATTGATAATATTCTTAACAATGCCATCAAGTATTCGCCAGATGGTGG
AAAAATCACAGTGACCATGAAGACGACTGATGATCAGATGATTTTATCCATCTCAGACCAAGGTTTGGGTATTCCTAAGC
AGGATTTACCACGTATTTTTGACCGTTTTTATCGTGTGGATCGTGCTAGAAGTCGTGCCCAGGGTGGAACAGGTCTGGGA
CTGTCTATTGCCAAAGAAATTATCAAACAACATAAAGGCTTTATTTGGGCCAAGAGTGAATACGGTAAGGGATCAACCTT
TACCATTGTGCTCCCTTATGATAAGGATGCAGTGAAAGAAGAAGTATGGGAGGATGAAGTAGAAGACTAG

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (324-434)

• PAS fold (PAS) (95-198)

• His Kinase A (phospho-acceptor) domain (HisKA) (209-273)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
micB	Streptococcus pneumoniae Cp1015	91.116	97.773	0.891
vicK	Streptococcus mutans UA159	72.637	89.532	0.65