Detailed information NTG0107296

Bioinformatically predicted

Overview

• Name: comD/comD2
• Type: Regulator
• Locus tag: ACAM22_RS00025
• Genome accession: NZ_AP028929
• Coordinates: 1518..2843 (+)
• Length: 441 a.a.
• NCBI ID: WP_023944979.1
• Uniprot ID: A0AAT9FY54
• Organism: Streptococcus sp. SN-1
• Function: phosphorylation of ComE (predicted from homology) Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
IS/Tn	3842..5098	1518..2843	flank	999

Gene organization within MGE regions

Location: 1518..5098

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACAM22_RS00025 (MASAN616_00030)	comD/comD2	1518..2843 (+)	1326	WP_023944979.1	competence system sensor histidine kinase ComD	Regulator
ACAM22_RS00030 (MASAN616_00040)	comE	2840..3592 (+)	753	WP_000866065.1	competence system response regulator transcription factor ComE	Regulator
ACAM22_RS00045 (MASAN616_00050)	-	3842..5098 (-)	1257	WP_265471657.1	ISL3 family transposase	-

Sequence

Protein

• Length: 441 a.a.
• Molecular weight: 51338.72 Da
• Isoelectric Point: 6.6408

>NTDB_id=107296 ACAM22_RS00025 WP_023944979.1 1518..2843(+) (comD/comD2) [Streptococcus sp. SN-1]
MNLFGFGTVIGHFLIISHSYRLICKGQIKSKELYFFGIYTLLVEAVLELSFYLLYLDEIVIERFLFPLGLYSYFRWIKQY
ERDRGLFLSLLLSLLYESTHNFLSVTFSSITGDNFVSQYHDPFFFVVTVLTYFVVLKIIHYFHLELAYFDKDYLYPFLKK
LFFALLLLHIVSFVSDMVSTIKHLNSFGSILSSIVFISLLLTFFAMNSHKEQMEKEIALKQKKFEQKHLQNYTDEIVGLY
NEIRGFRHDYAGMLVSMQIAIDSGDLQEIDRIYNEVLVKANHKLRSDKYTYFDLNNIEDSALRSLVAQSIVYARNNSVEF
TLEVKDTITKLPIELLDLVRIMSVLLNNAVEGSADSYKKQMEVAVIKMETETVIVIQNSCKMTMTPSGDLFALGFSTKGR
NRGVGLNNVKELLDKYNNIILETEMEGSTFRQIIRFKREFE

Nucleotide

• Length: 1326 bp

>NTDB_id=107296 ACAM22_RS00025 WP_023944979.1 1518..2843(+) (comD/comD2) [Streptococcus sp. SN-1]
ATGAATTTATTTGGATTTGGGACAGTTATTGGTCATTTTTTAATTATTAGTCACAGTTACCGTTTAATTTGTAAAGGTCA
AATAAAATCAAAGGAACTATATTTTTTTGGTATCTATACATTACTAGTAGAAGCAGTACTTGAACTTTCCTTTTATCTTC
TATATTTAGATGAAATAGTGATTGAAAGATTTTTATTTCCTTTGGGCTTATATTCCTATTTTCGATGGATTAAACAGTAT
GAGAGGGATAGAGGACTATTCCTAAGTTTACTACTATCTCTTTTATATGAGAGCACTCATAACTTTCTGTCCGTAACTTT
CTCCTCTATAACAGGAGATAACTTTGTTTCACAATATCATGACCCATTCTTTTTCGTTGTAACGGTGTTGACCTATTTTG
TTGTCTTAAAAATCATTCATTATTTCCATTTGGAACTAGCCTATTTTGACAAAGACTACCTCTATCCTTTTTTGAAAAAA
TTATTTTTTGCCTTACTACTGCTACATATAGTATCTTTTGTTTCAGATATGGTAAGTACGATTAAACATTTGAATAGTTT
TGGAAGTATTTTATCATCTATTGTCTTTATTTCTCTACTTTTGACCTTTTTTGCAATGAATTCGCATAAAGAACAAATGG
AGAAAGAGATTGCTTTGAAGCAGAAGAAATTTGAACAGAAACATTTACAGAATTATACAGATGAAATTGTTGGCTTGTAT
AATGAAATCCGTGGTTTTCGACATGACTATGCTGGGATGCTTGTCAGTATGCAGATAGCAATTGACAGTGGTGATTTACA
GGAAATTGACAGAATTTACAATGAAGTTTTGGTCAAAGCAAATCATAAACTGCGTTCAGATAAGTATACTTACTTTGATT
TGAACAACATAGAAGATTCAGCTTTACGAAGTTTGGTTGCTCAGTCCATTGTCTATGCTCGAAATAATAGTGTAGAGTTT
ACACTGGAAGTAAAAGATACGATTACCAAGCTCCCAATTGAACTATTGGATTTGGTTCGTATCATGAGCGTTTTATTGAA
TAATGCTGTCGAAGGATCGGCTGATAGTTATAAAAAGCAGATGGAAGTAGCAGTTATTAAGATGGAAACTGAAACAGTTA
TTGTGATTCAGAATTCATGTAAAATGACGATGACTCCTTCAGGAGATCTATTTGCTTTAGGATTCTCCACTAAGGGAAGA
AATCGCGGGGTAGGATTAAATAATGTGAAAGAACTACTAGATAAGTACAACAATATTATTTTAGAAACAGAGATGGAAGG
CAGTACATTTAGACAAATTATTAGATTTAAGAGGGAATTTGAATGA

Domains

Predicted by InterproScan.

• GHKL domain (HATPase_c_5) (334-434)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comD/comD2	Streptococcus pneumoniae TIGR4	94.558	100	0.946
comD/comD1	Streptococcus pneumoniae Rx1	92.971	100	0.93
comD/comD1	Streptococcus pneumoniae D39	92.971	100	0.93
comD/comD1	Streptococcus pneumoniae R6	92.971	100	0.93
comD	Streptococcus mitis SK321	90.249	100	0.902
comD	Streptococcus mitis NCTC 12261	86.395	100	0.864
comD/comD1	Streptococcus gordonii str. Challis substr. CH1	49.734	85.261	0.424
comD/comD2	Streptococcus gordonii strain NCTC7865	49.468	85.261	0.422