Detailed information NTG0107185

Bioinformatically predicted

Overview

• Name: ciaH
• Type: Regulator
• Locus tag: AAA995_RS03800
• Genome accession: NZ_AP028877
• Coordinates: 738132..739466 (+)
• Length: 444 a.a.
• NCBI ID: WP_255123896.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain 21P20
• Function: repress competence development; post-transcriptional repression of CSP production (predicted from homology) Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
IS/Tn	736016..737272	738132..739466	flank	860

Gene organization within MGE regions

Location: 736016..739466

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
AAA995_RS03790 (SP21P20_07450)	-	736016..737272 (-)	1257	WP_000530083.1	ISL3 family transposase	-
AAA995_RS03795 (SP21P20_07460)	ciaR	737468..738142 (+)	675	WP_000590640.1	two-component system response regulator CiaR	Regulator
AAA995_RS03800 (SP21P20_07470)	ciaH	738132..739466 (+)	1335	WP_255123896.1	two-component system sensor histidine kinase CiaH	Regulator

Sequence

Protein

• Length: 444 a.a.
• Molecular weight: 50701.44 Da
• Isoelectric Point: 9.1661

>NTDB_id=107185 AAA995_RS03800 WP_255123896.1 738132..739466(+) (ciaH) [Streptococcus pneumoniae strain 21P20]
MFSKLKKTWYADDFSYFIRNFGVFTLIFSTMTLIILQVMHSSLYTSVDDKLHGLSENPQAVIQLAINRATEEIKDLENAR
ADASKVEIKPNVSSNTEVILFDKDFTQLLSGNRFLGLDKIKLEKKELGHIYQIQVFNSYGQEEIYRVILMETNISSVSTN
IKYAAVLINTSQLEQASQKHEQLIVVVMASFWILSLLASLYLARVSVRPLLESMQKQQSFVENASHELRTPLAVLQNRLE
TLFRKPEATIMDVSESIASSLEEVRNMRFLTTSLLNLARRDDGIKPELAEVPTSFFNTTFTNYEMIASENNRVFRFENRI
HRTIVTDQLLLKQLMTILFDNAVKYTEEDGEIDFLISATDRNLYLLVSDNGIGISTEDKKKIFDRFYRVDKARTRQKGGF
GLGLSLAKQIVDALKGTVTVKDNKPKGTIFEVKIVIQTPSKKKK

Nucleotide

• Length: 1335 bp

>NTDB_id=107185 AAA995_RS03800 WP_255123896.1 738132..739466(+) (ciaH) [Streptococcus pneumoniae strain 21P20]
ATGTTCAGTAAACTTAAAAAAACATGGTATGCGGATGACTTTAGTTATTTTATCCGCAACTTCGGTGTCTTCACCCTGAT
TTTTTCTACAATGACTCTGATTATTTTACAAGTCATGCATTCGAGTCTTTATACTTCGGTGGACGATAAGCTTCATGGAC
TGAGTGAAAATCCTCAAGCAGTTATTCAGCTGGCTATAAATAGGGCAACAGAAGAGATTAAAGATTTAGAAAATGCTAGG
GCGGACGCTAGTAAAGTAGAAATAAAACCTAATGTCAGTTCCAATACGGAAGTCATTCTCTTTGATAAAGACTTTACTCA
ACTTCTTTCTGGAAATCGATTTTTGGGCTTGGATAAGATTAAGTTAGAAAAGAAAGAACTAGGACATATCTACCAGATTC
AGGTTTTTAATAGCTATGGGCAGGAAGAAATCTATCGTGTGATTTTGATGGAGACCAATATTAGTTCGGTTTCAACCAAT
ATCAAGTATGCTGCTGTCTTGATTAATACCAGTCAGTTGGAGCAGGCTAGTCAAAAGCATGAGCAATTGATTGTGGTCGT
GATGGCTAGTTTCTGGATTTTGTCTTTACTTGCCAGTCTCTATCTAGCTAGGGTCAGTGTTAGGCCCCTGCTTGAGAGTA
TGCAGAAGCAACAGTCTTTTGTGGAAAATGCCAGTCATGAGTTACGAACTCCACTCGCAGTTTTGCAAAATCGCTTAGAG
ACCCTTTTTCGTAAGCCAGAAGCTACCATTATGGATGTGAGCGAAAGCATTGCATCGAGTTTGGAAGAAGTCCGAAATAT
GCGTTTTTTAACGACAAGCTTGCTGAACTTAGCTCGGAGAGATGATGGGATTAAGCCGGAGCTTGCAGAAGTTCCAACTA
GCTTTTTTAATACAACTTTCACAAACTATGAGATGATTGCTTCGGAAAATAATCGTGTCTTCCGTTTTGAAAATCGTATC
CATCGAACAATTGTCACAGATCAGCTTCTTCTGAAACAACTGATGACCATTCTTTTCGATAATGCCGTCAAGTATACTGA
GGAGGATGGTGAAATTGATTTTCTTATCTCGGCGACCGATCGCAATCTTTATTTACTTGTTTCTGATAATGGAATCGGTA
TTTCGACAGAAGATAAAAAGAAAATTTTTGACCGTTTTTATCGAGTAGACAAGGCTAGAACCCGGCAAAAAGGTGGTTTT
GGTTTAGGATTATCCCTAGCCAAGCAAATTGTAGATGCTCTAAAAGGAACTGTTACTGTCAAAGATAATAAACCCAAGGG
AACAATCTTTGAAGTGAAGATTGTCATTCAGACACCATCTAAAAAGAAAAAATAA

Domains

Predicted by InterproScan.

• His Kinase A (phospho-acceptor) domain (HisKA) (217-283)

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (327-434)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaH	Streptococcus pneumoniae Rx1	99.775	100	0.998
ciaH	Streptococcus pneumoniae D39	99.775	100	0.998
ciaH	Streptococcus pneumoniae R6	99.775	100	0.998
ciaH	Streptococcus pneumoniae TIGR4	99.775	100	0.998
ciaH	Streptococcus mutans UA159	55.505	98.198	0.545