Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaH   Type   Regulator
Locus tag   AAA996_RS03655 Genome accession   NZ_AP028606
Coordinates   721758..723092 (+) Length   444 a.a.
NCBI ID   WP_000491786.1    Uniprot ID   -
Organism   Streptococcus pneumoniae strain Sep1     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 716758..728092
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  AAA996_RS03635 (TKY121773_07110) - 717032..717901 (+) 870 WP_000795794.1 putative PEP-binding protein -
  AAA996_RS03640 (TKY121773_07120) - 717876..718316 (+) 441 WP_000612883.1 ASCH domain-containing protein -
  AAA996_RS03645 (TKY121773_07130) - 718439..720985 (+) 2547 WP_001149118.1 M1 family metallopeptidase -
  AAA996_RS03650 (TKY121773_07140) ciaR 721094..721768 (+) 675 WP_000590640.1 two-component system response regulator CiaR Regulator
  AAA996_RS03655 (TKY121773_07150) ciaH 721758..723092 (+) 1335 WP_000491786.1 two-component system sensor histidine kinase CiaH Regulator
  AAA996_RS03660 (TKY121773_07160) - 723126..723413 (-) 288 WP_001145225.1 DUF3270 domain-containing protein -
  AAA996_RS03665 (TKY121773_07170) - 723553..724482 (+) 930 WP_000411862.1 peptidase U32 family protein -
  AAA996_RS03670 (TKY121773_07180) - 724682..727132 (+) 2451 WP_000848718.1 bifunctional DnaQ family exonuclease/ATP-dependent helicase -

Sequence

Protein


Download         Length: 444 a.a.        Molecular weight: 50687.41 Da        Isoelectric Point: 9.1661

>NTDB_id=106190 AAA996_RS03655 WP_000491786.1 721758..723092(+) (ciaH) [Streptococcus pneumoniae strain Sep1]
MFSKLKKTWYADDFSYFIRNFGVFTLIFSTMTLIILQVMHSSLYTSVDDKLHGLSENPQAVIQLAINRATEEIKDLENAR
ADASKVEIKPNVSSNTEVILFDKDFTQLLSGNRFLGLDKIKLEKKELGHIYQIQVFNSYGQEEIYRVILMETNISSVSTN
IKYAAVLINTSQLEQASQKHEQLIVIVMASFWILSLLASLYLARVSVRPLLESMQKQQSFVENASHELRTPLAVLQNRLE
TLFRKPEATIMDVSESIASSLEEVRNMRFLTTSLLNLARRDDGIKPELAEVPTSFFNTTFTNYEMIASENNRVFRFENRI
HRTIVTDQLLLKQLMTILFDNAVKYTEEDGEIDFLISATDRNLYLLVSDNGIGISTEDKKKIFDRFYRVDKARTRQKGGF
GLGLSLAKQIVDALKGTVTVKDNKPKGTIFEVKIAIQTPSKKKK

Nucleotide


Download         Length: 1335 bp        

>NTDB_id=106190 AAA996_RS03655 WP_000491786.1 721758..723092(+) (ciaH) [Streptococcus pneumoniae strain Sep1]
ATGTTCAGTAAACTTAAAAAAACATGGTATGCGGATGACTTTAGTTATTTTATCCGCAACTTCGGTGTCTTCACCCTGAT
TTTTTCTACAATGACTCTGATTATTTTACAAGTCATGCATTCGAGTCTTTATACTTCGGTGGACGATAAGCTTCATGGAC
TGAGTGAAAATCCTCAAGCAGTTATTCAGCTGGCTATAAATAGGGCAACAGAAGAGATTAAAGATTTAGAAAATGCTAGG
GCGGACGCTAGTAAAGTAGAAATAAAACCTAATGTCAGTTCCAATACGGAAGTCATTCTCTTTGATAAGGACTTTACTCA
ACTTCTTTCTGGAAATCGATTTTTGGGCTTGGATAAGATTAAGTTAGAAAAGAAAGAACTAGGACATATCTACCAGATTC
AGGTTTTTAATAGCTATGGGCAGGAAGAAATCTATCGTGTGATTTTGATGGAGACCAATATTAGTTCGGTTTCAACCAAT
ATCAAGTATGCTGCTGTCTTGATTAATACCAGTCAGTTGGAGCAGGCTAGTCAAAAGCATGAGCAATTGATTGTGATCGT
GATGGCTAGTTTCTGGATTTTGTCTTTACTTGCCAGTCTCTATCTAGCTAGGGTCAGTGTTAGGCCCCTGCTTGAGAGTA
TGCAGAAGCAACAGTCTTTTGTGGAAAATGCCAGTCATGAGTTACGAACTCCACTCGCAGTTTTGCAAAATCGCTTAGAG
ACCCTTTTTCGTAAGCCAGAAGCTACCATTATGGATGTGAGTGAAAGCATTGCATCGAGTTTGGAAGAAGTCCGAAATAT
GCGTTTTTTAACGACAAGCTTGCTGAACTTAGCTCGGAGAGATGATGGGATTAAGCCAGAGCTTGCAGAAGTTCCAACTA
GCTTTTTTAATACAACTTTCACAAACTATGAGATGATTGCTTCGGAAAATAATCGTGTCTTCCGTTTTGAAAATCGTATC
CATCGAACAATTGTCACAGATCAGCTTCTTCTGAAACAACTGATGACCATTCTTTTCGATAATGCCGTCAAGTATACTGA
GGAGGATGGTGAAATTGATTTTCTTATCTCGGCGACCGATCGCAATCTTTATTTACTTGTTTCTGATAATGGAATCGGTA
TTTCGACAGAAGATAAAAAGAAAATTTTTGACCGTTTTTATCGAGTAGACAAGGCTAGAACCCGGCAAAAAGGTGGTTTT
GGTTTAGGATTATCCCTAGCCAAGCAAATTGTAGATGCTCTAAAAGGAACTGTTACTGTCAAAGATAATAAACCCAAGGG
AACAATCTTTGAAGTGAAGATTGCCATTCAGACACCATCTAAAAAGAAAAAATAA

Domains

Predicted by InterproScan.

His Kinase A (phospho-acceptor) domain (HisKA)

(217-283)

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(327-434)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaH Streptococcus pneumoniae Rx1

99.775

100

0.998
  ciaH Streptococcus pneumoniae D39

99.775

100

0.998
  ciaH Streptococcus pneumoniae R6

99.775

100

0.998
  ciaH Streptococcus pneumoniae TIGR4

99.775

100

0.998
  ciaH Streptococcus mutans UA159

55.632

97.973

0.545

Multiple sequence alignment