Detailed information    

insolico Bioinformatically predicted

Overview

Name   hexB   Type   Machinery gene
Locus tag   DK43_RS00645 Genome accession   NZ_CP007573
Coordinates   127916..129862 (+) Length   648 a.a.
NCBI ID   WP_037593386.1    Uniprot ID   -
Organism   Streptococcus anginosus strain SA1     
Function   DNA mismatch repair (predicted from homology)   
Homologous recombination

Genomic Context

Location: 122916..134862
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DK43_RS00620 (DK43_00640) - 123047..124036 (+) 990 WP_003027787.1 Abi family protein -
  DK43_RS00625 (DK43_00645) rhuM 124057..124380 (+) 324 Protein_123 RhuM family protein -
  DK43_RS00630 (DK43_00650) - 124630..124905 (+) 276 WP_022525216.1 helix-turn-helix domain-containing protein -
  DK43_RS00635 (DK43_00660) - 125079..126593 (+) 1515 WP_003027783.1 RNA-binding domain-containing protein -
  DK43_RS00640 (DK43_00665) - 126673..127821 (+) 1149 WP_003027782.1 site-specific integrase -
  DK43_RS00645 (DK43_00670) hexB 127916..129862 (+) 1947 WP_037593386.1 DNA mismatch repair endonuclease MutL Machinery gene
  DK43_RS00650 (DK43_00675) ruvA 129996..130586 (+) 591 WP_003027779.1 Holliday junction branch migration protein RuvA Machinery gene
  DK43_RS00655 (DK43_00680) - 130596..131150 (+) 555 WP_003027778.1 DNA-3-methyladenine glycosylase I -
  DK43_RS00660 (DK43_00685) - 131155..131813 (+) 659 Protein_130 lysostaphin resistance A-like protein -
  DK43_RS00665 (DK43_00690) - 131864..132274 (-) 411 WP_003027775.1 helix-turn-helix transcriptional regulator -
  DK43_RS00670 (DK43_00700) cinA 132544..133812 (+) 1269 WP_022525214.1 competence/damage-inducible protein A Machinery gene

Sequence

Protein


Download         Length: 648 a.a.        Molecular weight: 73137.29 Da        Isoelectric Point: 5.1093

>NTDB_id=106089 DK43_RS00645 WP_037593386.1 127916..129862(+) (hexB) [Streptococcus anginosus strain SA1]
MSKIIELPENLANQIAAGEVIERPSSVVKELIENSIDAGATQIIVEIEEAGLRSIQVIDNGEGIEPEEVSLALRRHATSK
IKKQADLFRIRTLGFRGEALPSIASVSRLTIETATNGGTHGTLLIAQGGEIETIEPSSCPRGTKIKVEDLFFNTPARLKY
MKSQQAELSHIVDVMNRLSLAHPEVAFILLNDGKELTRTAGTGNLRQAIAGIYGLTTAKKMIEISASDLDFEVSGYISLP
ELTRANRNYITILINGRYIKNFLLNRAILDGYSSKLMVGRFPIAVIAIQIDPYLADVNVHPTKQEVRISKERELMALISQ
AISASLKEQDLIPDALENLAKSTINRANKPEQTSLPLKENRLYYDKERNDFFVKPQVSEAQPSFEESDRLDQQSADTDKL
NSKAASVKFAERQSPSYNQLDHPELDQASLERALDKLGGEETSTFPELEYFGQMHGTYLFAQGNGGLYIIDQHAAQERVK
YEYYREKIGDVDASQQQLLVPYIFEFPADDMLRLKQRMSLLEEVGIFLEEYGANQFILREHPIWLKEEEIESGIYEMCDM
LLLTKEVSIKKYRAELAIMMSCKRSIKANHSLDDYSARDLIFQLSQCDNPYNCPHGRPVLVNFTKSDMEKMFRRIQENHT
SLRELGKY

Nucleotide


Download         Length: 1947 bp        

>NTDB_id=106089 DK43_RS00645 WP_037593386.1 127916..129862(+) (hexB) [Streptococcus anginosus strain SA1]
ATGTCAAAAATTATAGAATTACCAGAAAATCTTGCCAATCAGATTGCGGCAGGTGAGGTCATTGAGCGACCTAGCAGCGT
TGTCAAAGAGTTGATAGAAAACTCTATTGATGCTGGTGCCACTCAGATTATAGTTGAGATTGAAGAAGCAGGACTCAGGA
GCATTCAAGTCATTGATAATGGTGAAGGAATTGAGCCTGAGGAGGTTTCCTTGGCTTTGCGGCGGCATGCTACTAGTAAA
ATCAAGAAACAAGCCGACCTTTTTCGAATTCGGACATTAGGCTTTCGCGGTGAGGCGCTTCCGTCGATTGCTTCTGTTTC
ACGCTTGACGATTGAAACTGCGACAAATGGTGGAACACATGGAACGCTTCTGATTGCGCAAGGTGGAGAAATTGAAACTA
TAGAACCAAGTAGCTGTCCTAGAGGCACCAAAATCAAGGTGGAAGATCTCTTTTTCAACACACCTGCTCGCTTAAAATAT
ATGAAAAGTCAACAAGCAGAACTGTCTCACATTGTAGATGTAATGAACCGTTTGAGTCTAGCACATCCAGAGGTTGCTTT
TATCTTGCTCAATGATGGTAAAGAGTTGACTCGGACGGCAGGAACAGGAAATCTGCGTCAAGCAATTGCTGGCATTTATG
GACTGACAACAGCCAAAAAAATGATTGAAATTTCAGCATCTGATTTGGATTTTGAAGTATCAGGCTATATTAGTTTGCCA
GAATTAACAAGGGCTAATCGGAATTACATTACTATCCTCATCAATGGTCGTTACATCAAGAATTTCCTGCTCAATCGAGC
TATTCTTGATGGTTACAGTAGTAAGCTCATGGTTGGGCGATTCCCGATTGCTGTGATTGCTATCCAGATTGATCCTTACC
TTGCGGATGTTAATGTTCATCCGACCAAGCAAGAAGTGCGGATTTCAAAAGAGAGAGAACTGATGGCCTTGATTTCGCAA
GCCATTTCTGCGAGTTTAAAAGAGCAGGATTTGATTCCGGACGCTTTGGAAAATTTAGCAAAATCAACCATTAACCGAGC
AAATAAGCCTGAGCAGACGAGTCTCCCACTCAAAGAAAACCGACTCTATTACGATAAAGAAAGAAATGACTTCTTTGTGA
AACCACAAGTGTCAGAAGCTCAACCTTCTTTTGAGGAATCTGACCGATTAGACCAACAATCTGCTGATACAGATAAACTC
AATTCAAAAGCTGCTTCTGTCAAATTTGCAGAAAGGCAATCTCCTTCTTACAATCAACTAGATCATCCAGAGCTGGATCA
GGCGAGCTTAGAGAGAGCTTTAGATAAGTTGGGTGGAGAAGAAACTTCAACTTTTCCAGAATTGGAATATTTCGGGCAAA
TGCACGGCACCTACCTTTTTGCTCAAGGAAACGGTGGCCTTTATATTATTGATCAACATGCAGCTCAAGAGCGAGTAAAG
TACGAATATTACCGCGAAAAAATCGGAGATGTAGATGCTAGTCAGCAACAGCTTTTGGTTCCCTATATCTTTGAATTTCC
AGCCGATGATATGCTACGTCTGAAACAACGAATGTCTCTTTTAGAAGAAGTGGGGATTTTCCTAGAAGAATATGGGGCTA
ATCAATTTATTCTTCGTGAACATCCCATTTGGCTTAAGGAAGAGGAGATCGAATCAGGTATTTATGAGATGTGCGATATG
CTGCTTCTAACCAAGGAAGTCTCTATCAAGAAATATCGCGCTGAGCTAGCTATTATGATGAGTTGCAAACGCTCTATTAA
AGCCAATCACAGTTTGGATGACTATTCAGCGCGTGATTTGATTTTTCAGTTATCACAATGTGACAATCCCTACAATTGTC
CACATGGTCGTCCCGTTTTGGTCAACTTTACCAAATCTGATATGGAAAAAATGTTCCGTCGGATTCAGGAAAATCATACC
AGTCTGAGAGAATTGGGGAAATACTAA

Domains

Predicted by InterProScan.

MutL C terminal dimerisation domain (MutL_C)

(450-592)

DNA mismatch repair protein, C-terminal domain (DNA_mis_repair)

(209-326)

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c_3)

(25-118)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  hexB Streptococcus pneumoniae R6

76.425

100

0.765

Multiple sequence alignment