Detailed information    

insolico Bioinformatically predicted

Overview

Name   comM   Type   Regulator
Locus tag   AAA982_RS09015 Genome accession   NZ_AP028601
Coordinates   1745064..1745684 (-) Length   206 a.a.
NCBI ID   WP_000839908.1    Uniprot ID   A0A0B7M636
Organism   Streptococcus pneumoniae strain PF1     
Function   fratricide immunity (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Genomic island 1734767..1756752 1745064..1745684 within 0


Gene organization within MGE regions


Location: 1734767..1756752
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  AAA982_RS08955 (TKY113292_17530) - 1734767..1735351 (-) 585 WP_081544138.1 hypothetical protein -
  AAA982_RS08960 (TKY113292_17540) - 1735760..1736185 (-) 426 WP_000204070.1 hypothetical protein -
  AAA982_RS08965 (TKY113292_17550) - 1736314..1736673 (-) 360 WP_000749821.1 hypothetical protein -
  AAA982_RS08970 (TKY113292_17560) - 1736719..1736925 (-) 207 WP_000366087.1 hypothetical protein -
  AAA982_RS08975 (TKY113292_17570) - 1736912..1737073 (-) 162 WP_000289348.1 helix-turn-helix transcriptional regulator -
  AAA982_RS08980 (TKY113292_17580) lytA 1737432..1738388 (-) 957 WP_000405234.1 N-acetylmuramoyl-L-alanine amidase LytA -
  AAA982_RS08985 (TKY113292_17590) - 1738764..1740134 (-) 1371 WP_130894686.1 MATE family efflux transporter -
  AAA982_RS08990 (TKY113292_17600) recA 1740441..1741607 (-) 1167 WP_001085463.1 recombinase RecA Machinery gene
  AAA982_RS08995 (TKY113292_17610) cinA 1741662..1742918 (-) 1257 WP_000642707.1 competence/damage-inducible protein A Machinery gene
  AAA982_RS09000 (TKY113292_17620) - 1743003..1744019 (-) 1017 WP_000239282.1 LCP family protein -
  AAA982_RS09005 (TKY113292_17630) - 1744027..1744545 (-) 519 WP_000455537.1 GNAT family N-acetyltransferase -
  AAA982_RS09010 (TKY113292_17640) tsaE 1744535..1744978 (-) 444 WP_000275589.1 tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE -
  AAA982_RS09015 (TKY113292_17650) comM 1745064..1745684 (-) 621 WP_000839908.1 hypothetical protein Regulator
  AAA982_RS09020 (TKY113292_17660) - 1746067..1746930 (-) 864 WP_001093620.1 helix-turn-helix transcriptional regulator -
  AAA982_RS09025 (TKY113292_17670) - 1747122..1747292 (+) 171 WP_001227862.1 PhrA family quorum-sensing system peptide -
  AAA982_RS09030 (TKY113292_17680) pneA1 1747395..1747619 (+) 225 WP_000181087.1 two-peptide bacteriocin subunit PneA1 -
  AAA982_RS09035 (TKY113292_17690) pneA2 1747626..1747814 (+) 189 WP_000786759.1 two-peptide bacteriocin subunit PneA2 -
  AAA982_RS09040 (TKY113292_17700) lanM 1747930..1750920 (+) 2991 WP_000875571.1 type 2 lanthipeptide synthetase LanM -
  AAA982_RS09045 (TKY113292_17710) - 1751270..1751974 (+) 705 WP_001033170.1 flavodoxin family protein -
  AAA982_RS09050 (TKY113292_17720) - 1751955..1752884 (+) 930 WP_000912954.1 M50 family metallopeptidase -
  AAA982_RS09055 (TKY113292_17730) - 1752881..1754989 (+) 2109 WP_000701298.1 peptidase domain-containing ABC transporter -
  AAA982_RS09060 (TKY113292_17740) - 1755013..1756752 (+) 1740 WP_000699969.1 S8 family serine peptidase -

Sequence

Protein


Download         Length: 206 a.a.        Molecular weight: 23552.72 Da        Isoelectric Point: 10.1254

>NTDB_id=105832 AAA982_RS09015 WP_000839908.1 1745064..1745684(-) (comM) [Streptococcus pneumoniae strain PF1]
MKSMRILFLLALIQISLSSCFLWKECILSFKQSTAFFIGSMVFVSGICAGVNYLYTRKQEVHSVLASKKSVKLFYSMLLL
INLLGAVLVLSDNLFIKNTLQQELVDFLLPSFFFLFGLDLLIFLPLKKYVRDFLAMLDRKKTVLVTILATLLFLRNPMTI
VSLLIYIGLGLFFAAYLVPNSVKKEVSFYGHIFRDLVLVIVTLIFF

Nucleotide


Download         Length: 621 bp        

>NTDB_id=105832 AAA982_RS09015 WP_000839908.1 1745064..1745684(-) (comM) [Streptococcus pneumoniae strain PF1]
ATGAAATCAATGAGAATCTTATTTTTGTTAGCTTTAATTCAAATCAGTTTGAGTAGCTGTTTCTTATGGAAGGAATGCAT
CTTGTCCTTTAAACAAAGTACAGCTTTTTTCATCGGAAGCATGGTTTTCGTTTCAGGAATCTGTGCTGGAGTAAATTATC
TTTATACCCGTAAGCAAGAAGTCCATAGTGTCCTAGCCAGTAAGAAGTCGGTGAAGCTTTTTTACAGTATGTTACTCTTA
ATTAATTTGTTAGGAGCTGTTCTTGTTTTGTCAGATAACTTGTTCATCAAAAATACGCTGCAGCAAGAATTAGTTGACTT
TTTATTGCCATCCTTCTTTTTCCTATTTGGGCTAGATTTGCTGATTTTTTTACCCTTGAAAAAATACGTGCGCGATTTTC
TTGCTATGCTAGACAGAAAAAAGACAGTGTTGGTGACTATTTTAGCAACACTTCTTTTCTTAAGAAATCCAATGACCATT
GTCTCACTTCTGATTTATATTGGACTGGGCTTGTTTTTTGCAGCCTATCTTGTCCCAAATTCGGTTAAGAAGGAAGTTTC
CTTTTATGGTCATATTTTCCGAGATCTTGTATTGGTCATTGTTACGCTCATTTTCTTTTAG

Domains


No domain identified.



Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0B7M636

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comM Streptococcus pneumoniae D39

100

100

1
  comM Streptococcus pneumoniae R6

100

100

1
  comM Streptococcus pneumoniae TIGR4

100

100

1
  comM Streptococcus mitis NCTC 12261

38.974

94.66

0.369
  comM Streptococcus mitis SK321

38.974

94.66

0.369

Multiple sequence alignment