Detailed information    

insolico Bioinformatically predicted

Overview

Name   vraR   Type   Regulator
Locus tag   ACFIOO_RS09880 Genome accession   NZ_CP170406
Coordinates   1992975..1993604 (-) Length   209 a.a.
NCBI ID   WP_000153535.1    Uniprot ID   W8TS97
Organism   Staphylococcus aureus strain t21635     
Function   repress expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 1987975..1998604
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ACFIOO_RS09850 - 1988398..1988928 (-) 531 WP_000184383.1 acyl-CoA thioesterase -
  ACFIOO_RS09855 - 1989018..1990274 (-) 1257 WP_077446664.1 aminopeptidase -
  ACFIOO_RS09860 - 1990277..1990477 (-) 201 WP_000180460.1 DUF1128 family protein -
  ACFIOO_RS09865 - 1990624..1991088 (+) 465 WP_054189636.1 low molecular weight protein-tyrosine-phosphatase -
  ACFIOO_RS09870 - 1991095..1991370 (+) 276 WP_000428172.1 YtxH domain-containing protein -
  ACFIOO_RS09875 - 1991648..1992865 (+) 1218 WP_000037088.1 YihY/virulence factor BrkB family protein -
  ACFIOO_RS09880 vraR 1992975..1993604 (-) 630 WP_000153535.1 two-component system response regulator VraR Regulator
  ACFIOO_RS09885 vraS 1993594..1994637 (-) 1044 WP_001017131.1 sensor histidine kinase Regulator
  ACFIOO_RS09890 liaF 1994634..1995335 (-) 702 WP_000149064.1 cell wall-active antibiotics response protein LiaF -
  ACFIOO_RS09895 - 1995350..1995736 (-) 387 WP_001110179.1 hypothetical protein -
  ACFIOO_RS09900 map 1995953..1996711 (-) 759 WP_000636142.1 type I methionyl aminopeptidase -
  ACFIOO_RS09905 - 1997471..1998457 (+) 987 WP_054189634.1 FUSC family protein -

Sequence

Protein


Download         Length: 209 a.a.        Molecular weight: 23559.32 Da        Isoelectric Point: 5.3935

>NTDB_id=1056865 ACFIOO_RS09880 WP_000153535.1 1992975..1993604(-) (vraR) [Staphylococcus aureus strain t21635]
MTIKVLFVDDHEMVRIGISSYLSTQSDIEVVGEGASGKEAIAKAHELKPDLILMDLLMEDMDGVEATTQIKKDLPQIKVL
MLTSFIEDKEVYRALDAGVDSYILKTTSAKDIADAVRKTSRGESVFEPEVLVKMRNRMKKRAELYEMLTEREMEILLLIA
KGYSNQEIASASHITIKTVKTHVSNILSKLEVQDRTQAVIYAFQHNLIQ

Nucleotide


Download         Length: 630 bp        

>NTDB_id=1056865 ACFIOO_RS09880 WP_000153535.1 1992975..1993604(-) (vraR) [Staphylococcus aureus strain t21635]
ATGACGATTAAAGTATTGTTTGTGGATGATCATGAAATGGTACGTATAGGAATTTCAAGTTATCTATCAACGCAAAGTGA
TATTGAAGTAGTTGGTGAAGGCGCTTCTGGTAAAGAAGCAATTGCCAAAGCCCATGAGTTGAAGCCAGATTTAATTTTAA
TGGATTTACTTATGGAAGACATGGATGGTGTAGAAGCGACGACTCAGATTAAAAAAGATTTACCGCAAATTAAAGTATTA
ATGTTAACTAGTTTTATTGAAGATAAAGAGGTATATCGTGCATTAGATGCAGGTGTCGATAGTTACATTTTAAAAACAAC
AAGTGCAAAAGATATCGCCGATGCAGTTCGTAAAACTTCTAGAGGAGAATCTGTTTTTGAACCGGAAGTTTTAGTGAAAA
TGCGTAATCGTATGAAAAAGCGCGCAGAGTTATATGAAATGCTTACAGAACGAGAAATGGAAATATTATTATTGATTGCG
AAAGGTTACTCAAATCAAGAAATTGCTAGTGCATCGCATATTACTATTAAAACGGTTAAGACACATGTGAGTAACATTTT
AAGTAAGTTAGAAGTTCAAGATAGAACGCAAGCTGTTATCTATGCATTCCAGCATAATTTAATTCAATAG

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(5-116)

Bacterial regulatory proteins, luxR family (GerE)

(147-202)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB W8TS97

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vraR Staphylococcus aureus N315

100

100

1
  degU Bacillus subtilis subsp. subtilis str. 168

34.821

100

0.373

Multiple sequence alignment