Detailed information NTG1056866

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: ACFIOO_RS09885
• Genome accession: NZ_CP170406
• Coordinates: 1993594..1994637 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain t21635
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1988594..1999637

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACFIOO_RS09855	-	1989018..1990274 (-)	1257	WP_077446664.1	aminopeptidase	-
ACFIOO_RS09860	-	1990277..1990477 (-)	201	WP_000180460.1	DUF1128 family protein	-
ACFIOO_RS09865	-	1990624..1991088 (+)	465	WP_054189636.1	low molecular weight protein-tyrosine-phosphatase	-
ACFIOO_RS09870	-	1991095..1991370 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
ACFIOO_RS09875	-	1991648..1992865 (+)	1218	WP_000037088.1	YihY/virulence factor BrkB family protein	-
ACFIOO_RS09880	vraR	1992975..1993604 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
ACFIOO_RS09885	vraS	1993594..1994637 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
ACFIOO_RS09890	liaF	1994634..1995335 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
ACFIOO_RS09895	-	1995350..1995736 (-)	387	WP_001110179.1	hypothetical protein	-
ACFIOO_RS09900	map	1995953..1996711 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
ACFIOO_RS09905	-	1997471..1998457 (+)	987	WP_054189634.1	FUSC family protein	-
ACFIOO_RS09910	-	1998966..1999379 (-)	414	WP_077446671.1	hypothetical protein	-
ACFIOO_RS09915	-	1999408..1999518 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=1056866 ACFIOO_RS09885 WP_001017131.1 1993594..1994637(-) (vraS) [Staphylococcus aureus strain t21635]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=1056866 ACFIOO_RS09885 WP_001017131.1 1993594..1994637(-) (vraS) [Staphylococcus aureus strain t21635]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTTATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACGGTTGGTATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAACGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACAAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTCCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCACTTGGTTTAAAAG
ACAAATCATTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1