Detailed information    

insolico Bioinformatically predicted

Overview

Name   agrA   Type   Regulator
Locus tag   ACFDA8_RS04040 Genome accession   NZ_CP170248
Coordinates   875275..875991 (-) Length   238 a.a.
NCBI ID   WP_001829999.1    Uniprot ID   C0LF82
Organism   Staphylococcus epidermidis strain PS25     
Function   promote expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 870275..880991
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ACFDA8_RS04025 (ACFDA8_04025) - 871556..872509 (+) 954 WP_002491544.1 LacI family DNA-binding transcriptional regulator -
  ACFDA8_RS04030 (ACFDA8_04030) - 872769..874241 (+) 1473 WP_002491534.1 sucrose-6-phosphate hydrolase -
  ACFDA8_RS04035 (ACFDA8_04035) - 874248..875207 (+) 960 WP_002499509.1 carbohydrate kinase -
  ACFDA8_RS04040 (ACFDA8_04040) agrA 875275..875991 (-) 717 WP_001829999.1 quorum-sensing response regulator AgrA Regulator
  ACFDA8_RS04045 (ACFDA8_04045) agrC 876008..877297 (-) 1290 Protein_791 quorum-sensing sensor histidine kinase AgrC -
  ACFDA8_RS04050 (ACFDA8_04050) agrD 877323..877463 (-) 141 WP_002468352.1 cyclic lactone autoinducer peptide AgrD -
  ACFDA8_RS04055 (ACFDA8_04055) - 877469..878032 (-) 564 WP_002491536.1 accessory gene regulator AgrB -
  ACFDA8_RS04060 (ACFDA8_04060) hld 878349..878426 (+) 78 WP_002494082.1 delta-hemolysin -
  ACFDA8_RS04065 (ACFDA8_04065) - 878807..879592 (-) 786 WP_161386733.1 carbon-nitrogen family hydrolase -

Sequence

Protein


Download         Length: 238 a.a.        Molecular weight: 27936.97 Da        Isoelectric Point: 5.6250

>NTDB_id=1055962 ACFDA8_RS04040 WP_001829999.1 875275..875991(-) (agrA) [Staphylococcus epidermidis strain PS25]
MKIFVCEDDQRQREHMVSIIKNYIMIEEKPMELALATNDPYEVLEQSKELNDIGCYFLDIQLEADMNGIKLASEIRKHDP
VGNIIFVTSHSELTYLTFVYKVAAMDFIFKDDPSELKMRIIDCLETAHTRLKLLSKESNVDTIELKRGSNSVYVQYDDIM
FFESSTKSHRLIAHLDNRQIEFYGNLKELAQLDERFFRCHNSFVINRHNIESIDSKERIVYFKNGENCFASVRNVKKI

Nucleotide


Download         Length: 717 bp        

>NTDB_id=1055962 ACFDA8_RS04040 WP_001829999.1 875275..875991(-) (agrA) [Staphylococcus epidermidis strain PS25]
ATGAAAATTTTTGTTTGTGAAGATGATCAAAGACAAAGAGAACATATGGTATCAATCATTAAAAACTACATAATGATTGA
AGAAAAGCCAATGGAGTTAGCTTTAGCAACAAATGATCCTTATGAGGTCTTAGAGCAATCAAAAGAACTTAATGACATTG
GTTGTTACTTCCTTGATATTCAATTAGAAGCTGATATGAACGGTATTAAATTAGCCAGTGAAATTCGTAAACATGATCCT
GTTGGTAATATTATATTTGTAACCAGCCACAGTGAACTGACTTATTTGACGTTTGTTTATAAAGTGGCTGCTATGGATTT
TATTTTTAAGGATGATCCATCTGAATTAAAAATGAGAATCATAGATTGTCTTGAAACAGCACATACACGACTCAAATTAT
TATCTAAAGAAAGTAATGTAGATACGATTGAGTTAAAACGTGGAAGTAATTCAGTATACGTTCAATATGATGATATTATG
TTTTTTGAATCATCTACGAAATCTCATAGACTCATCGCACATCTTGATAATCGACAAATTGAATTTTATGGAAATTTAAA
GGAATTAGCACAGCTTGATGAACGTTTCTTTAGATGTCATAACAGTTTTGTGATAAACAGGCATAACATTGAATCTATTG
ATTCAAAAGAACGTATTGTTTATTTTAAGAATGGCGAAAATTGTTTCGCTTCAGTACGTAATGTTAAAAAAATATAA

Domains

Predicted by InterproScan.

LytTr DNA-binding domain (LytTR)

(151-237)

Response regulator receiver domain (Response_reg)

(3-120)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB C0LF82

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  agrA Staphylococcus aureus N315

87.815

100

0.878
  comE/comE2 Streptococcus gordonii strain NCTC7865

35.178

100

0.374
  comE/comE1 Streptococcus gordonii str. Challis substr. CH1

35.178

100

0.374

Multiple sequence alignment