Detailed information NTG1053263

Bioinformatically predicted

Overview

• Name: ciaR
• Type: Regulator
• Locus tag: ACI1L5_RS19675
• Genome accession: NZ_OZ121091
• Coordinates: 4061169..4061828 (-)
• Length: 219 a.a.
• NCBI ID: WP_001221493.1
• Uniprot ID: Q3YXL4
• Organism: Escherichia coli isolate 366_BP0076
• Function: repress competence development; post-transcriptional repression of CSP production (predicted from homology) Competence regulation

Genomic Context

Location: 4056169..4066828

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACI1L5_RS19650 (KHEC_DIPIPN_19710)	parE	4056260..4058152 (+)	1893	WP_000195292.1	DNA topoisomerase IV subunit B	-
ACI1L5_RS19655 (KHEC_DIPIPN_19715)	ygiN	4058200..4058514 (-)	315	WP_000958598.1	putative quinol monooxygenase	-
ACI1L5_RS19660 (KHEC_DIPIPN_19720)	mdaB	4058545..4059126 (-)	582	WP_000065430.1	NADPH:quinone oxidoreductase MdaB	-
ACI1L5_RS19665	ygiZ	4059445..4059777 (+)	333	WP_023149630.1	DUF2645 family protein	-
ACI1L5_RS19670 (KHEC_DIPIPN_19725)	qseC	4059823..4061172 (-)	1350	WP_000673402.1	quorum sensing histidine kinase QseC	-
ACI1L5_RS19675 (KHEC_DIPIPN_19730)	ciaR	4061169..4061828 (-)	660	WP_001221493.1	quorum sensing response regulator transcription factor QseB	Regulator
ACI1L5_RS19680 (KHEC_DIPIPN_19735)	ygiW	4061980..4062372 (+)	393	WP_000712658.1	OB fold stress tolerance protein YgiW	-
ACI1L5_RS19685 (KHEC_DIPIPN_19740)	ygiV	4062425..4062907 (+)	483	WP_000183505.1	GyrI-like domain-containing protein	-
ACI1L5_RS19690 (KHEC_DIPIPN_19745)	mqsR	4063112..4063408 (+)	297	WP_000415584.1	type II toxin-antitoxin system toxin MqsR	-
ACI1L5_RS19695 (KHEC_DIPIPN_19750)	mqsA	4063410..4063805 (+)	396	WP_000650107.1	type II toxin-antitoxin system antitoxin MqsA	-
ACI1L5_RS19700 (KHEC_DIPIPN_19755)	ygiS	4063938..4065545 (+)	1608	WP_001295629.1	ABC transporter substrate-binding protein	-

Sequence

Protein

• Length: 219 a.a.
• Molecular weight: 24687.63 Da
• Isoelectric Point: 6.9850

>NTDB_id=1053263 ACI1L5_RS19675 WP_001221493.1 4061169..4061828(-) (ciaR) [Escherichia coli isolate 366_BP0076]
MRILLIEDDMLIGDGIKTGLSKMGFSVDWFTQGRQGKEALYSAPYDAVILDLTLPGMDGRDILREWREKGQREPVLILTA
RDALAERVEGLRLGADDYLCKPFALIEVAARLEALMRRTNGQASNELRHGNVMLDPGKRIATLAGEPLTLKPKEFALLEL
LMRNAGRVLPRKLIEEKLYTWDEEVTSNAVEVHVHHLRRKLGSDFIRTVHGIGYTLGEK

Nucleotide

• Length: 660 bp

>NTDB_id=1053263 ACI1L5_RS19675 WP_001221493.1 4061169..4061828(-) (ciaR) [Escherichia coli isolate 366_BP0076]
ATGCGAATTTTACTGATAGAAGATGACATGCTGATTGGCGACGGCATCAAAACGGGCCTTAGTAAAATGGGTTTTAGCGT
CGACTGGTTTACACAAGGTCGTCAGGGAAAAGAGGCGCTTTATAGCGCACCTTATGATGCGGTGATCCTGGATTTAACCT
TACCAGGCATGGATGGTCGCGATATTTTGCGCGAATGGCGAGAAAAAGGTCAGCGTGAGCCGGTACTGATCCTGACCGCG
CGCGATGCGCTGGCGGAACGTGTAGAAGGGCTGCGTCTGGGAGCTGACGATTATCTGTGTAAACCTTTTGCGTTGATAGA
AGTCGCCGCCAGGCTGGAAGCTCTGATGCGCCGAACCAACGGCCAGGCCAGCAACGAGCTGCGCCACGGTAACGTCATGC
TCGACCCCGGCAAACGTATCGCCACGCTGGCTGGCGAACCCTTAACACTGAAACCAAAAGAATTTGCCCTGCTGGAATTA
CTGATGCGTAACGCTGGTCGGGTACTGCCGCGCAAACTGATTGAAGAGAAACTGTATACCTGGGACGAAGAGGTCACCAG
TAATGCCGTTGAAGTGCATGTGCATCATCTGCGACGCAAACTCGGTAGTGATTTTATTCGTACCGTGCATGGTATTGGTT
ACACATTAGGTGAGAAATGA

Domains

Predicted by InterProScan.

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (145-216)

• Response regulator receiver domain (Response_reg) (3-112)

3D structure

• AlphaFold DB: Q3YXL4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaR	Streptococcus pneumoniae Rx1	38.326	100	0.397
ciaR	Streptococcus pneumoniae D39	38.326	100	0.397
ciaR	Streptococcus pneumoniae R6	38.326	100	0.397
ciaR	Streptococcus pneumoniae TIGR4	38.326	100	0.397
ciaR	Streptococcus mutans UA159	35.874	100	0.365