Detailed information NTG0105260

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: SPAP1_RS01140
• Genome accession: NZ_CP007537
• Coordinates: 207535..208275 (+)
• Length: 246 a.a.
• NCBI ID: WP_002986100.1
• Uniprot ID: A0A0H2UT50
• Organism: Streptococcus pyogenes strain AP1
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 202535..213275

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SPAP1_RS01125 (SPAP1_01120)	gltX	203065..204510 (+)	1446	WP_002986105.1	glutamate--tRNA ligase	-
SPAP1_RS01130 (SPAP1_01125)	-	204905..206251 (+)	1347	WP_011285380.1	sensor histidine kinase	-
SPAP1_RS01135 (SPAP1_01130)	-	206248..207531 (+)	1284	WP_010921869.1	sensor histidine kinase	-
SPAP1_RS01140 (SPAP1_01135)	comE/blpR	207535..208275 (+)	741	WP_002986100.1	LytTR family DNA-binding domain-containing protein	Regulator
SPAP1_RS01145 (SPAP1_01140)	rnpA	208815..209174 (+)	360	WP_002992035.1	ribonuclease P protein component	-
SPAP1_RS01150 (SPAP1_01145)	-	209140..209967 (+)	828	WP_010921871.1	YidC/Oxa1 family membrane protein insertase	-
SPAP1_RS01155 (SPAP1_01150)	jag	209979..210893 (+)	915	WP_010921872.1	RNA-binding cell elongation regulator Jag/EloR	-
SPAP1_RS01160 (SPAP1_01155)	rpmH	211208..211342 (+)	135	WP_002885866.1	50S ribosomal protein L34	-
SPAP1_RS01165 (SPAP1_01160)	-	211616..212320 (+)	705	WP_010921873.1	N-acetylmannosamine-6-phosphate 2-epimerase	-

Sequence

Protein

• Length: 246 a.a.
• Molecular weight: 28881.47 Da
• Isoelectric Point: 6.4841

>NTDB_id=105260 SPAP1_RS01140 WP_002986100.1 207535..208275(+) (comE/blpR) [Streptococcus pyogenes strain AP1]
MMNIFILEDDFIQQTRIESIVVGILKETRIPCNQLEVFSTPQKLFESIQERGDHQLYFLDIEIGEYTRCGLELAAAIRQK
DPNAVIVFVTTHSEFAPISFKYKVSALDFIDKAGGQKQFKEQIEECIRYTYDMMSSRESKDMFLFETPQTRLKLPYKDIL
YFATATTPHKVCLWTQTERLEFYGNLSEIQAVAPKLFLCHRSYLVNLDKVVRIDKSKQLLYFENGDSCMVSRLKMKCLFE
RWEALR

Nucleotide

• Length: 741 bp

>NTDB_id=105260 SPAP1_RS01140 WP_002986100.1 207535..208275(+) (comE/blpR) [Streptococcus pyogenes strain AP1]
ATGATGAACATTTTTATTCTTGAGGATGATTTTATCCAGCAGACACGCATAGAATCTATCGTAGTAGGCATCTTAAAAGA
GACTAGAATACCATGTAATCAGCTTGAAGTGTTCTCGACTCCTCAAAAATTATTTGAGAGTATCCAAGAAAGAGGAGACC
ATCAGCTGTATTTTTTAGATATTGAAATTGGTGAATATACTCGTTGTGGGCTTGAATTAGCTGCAGCTATTCGACAAAAA
GATCCTAATGCCGTTATTGTGTTTGTCACCACTCATTCAGAATTTGCTCCTATTTCTTTTAAATATAAGGTATCCGCTCT
AGATTTTATTGATAAAGCAGGTGGTCAAAAACAGTTTAAAGAACAAATCGAAGAATGTATCCGATATACTTACGATATGA
TGTCTAGTCGTGAGTCAAAGGACATGTTTTTATTTGAGACTCCACAGACAAGATTAAAATTGCCCTATAAGGATATTTTA
TACTTTGCTACAGCCACAACTCCTCACAAAGTTTGTTTATGGACTCAGACAGAAAGATTAGAGTTTTATGGTAATCTATC
TGAGATTCAAGCAGTAGCACCGAAACTTTTTTTGTGCCATAGATCCTACCTTGTGAATCTAGATAAGGTTGTTCGAATTG
ATAAGAGTAAGCAGCTCCTTTATTTCGAAAATGGTGATTCTTGTATGGTATCACGATTAAAAATGAAATGTCTGTTTGAA
CGGTGGGAGGCTCTTCGCTAA

Domains

Predicted by InterProScan.

• LytTr DNA-binding domain (LytTR) (152-242)

• Response regulator receiver domain (Response_reg) (4-123)

3D structure

• AlphaFold DB: A0A0H2UT50

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	46.862	97.154	0.455
comE/comE1	Streptococcus equinus JB1	41.597	96.748	0.402
comE/comE2	Streptococcus equinus JB1	39.431	100	0.394
comE	Streptococcus pneumoniae Rx1	38.525	99.187	0.382
comE	Streptococcus pneumoniae D39	38.525	99.187	0.382
comE	Streptococcus pneumoniae R6	38.525	99.187	0.382
comE	Streptococcus pneumoniae TIGR4	38.525	99.187	0.382
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	37.903	100	0.382
comE/comE2	Streptococcus gordonii strain NCTC7865	37.903	100	0.382
comE	Streptococcus mitis NCTC 12261	37.759	97.967	0.37
comE	Streptococcus mitis SK321	37.759	97.967	0.37