Detailed information    

insolico Bioinformatically predicted

Overview

Name   crp   Type   Regulator
Locus tag   ACDK45_RS03315 Genome accession   NZ_CP167879
Coordinates   643091..643765 (+) Length   224 a.a.
NCBI ID   WP_005647998.1    Uniprot ID   Q4QLV0
Organism   Haemophilus influenzae strain NTHi52     
Function   promote expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 638091..648765
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ACDK45_RS03280 (ACDK45_03280) rpmG 639008..639178 (-) 171 WP_005613503.1 50S ribosomal protein L33 -
  ACDK45_RS03285 (ACDK45_03285) rpmB 639190..639426 (-) 237 WP_005542826.1 50S ribosomal protein L28 -
  ACDK45_RS03290 (ACDK45_03290) radC 639640..640305 (-) 666 WP_013526173.1 DNA repair protein RadC -
  ACDK45_RS03295 (ACDK45_03295) coaBC 640468..641670 (+) 1203 WP_011272308.1 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase CoaBC -
  ACDK45_RS03300 (ACDK45_03300) dut 641718..642173 (+) 456 WP_005631431.1 dUTP diphosphatase -
  ACDK45_RS03305 (ACDK45_03305) slmA 642177..642833 (+) 657 WP_005648000.1 nucleoid occlusion factor SlmA -
  ACDK45_RS03310 (ACDK45_03310) - 642855..643106 (+) 252 WP_005647999.1 YheU family protein -
  ACDK45_RS03315 (ACDK45_03315) crp 643091..643765 (+) 675 WP_005647998.1 cAMP-activated global transcriptional regulator CRP Regulator
  ACDK45_RS03320 (ACDK45_03320) rlmC 644130..645305 (-) 1176 WP_021034785.1 23S rRNA (uracil(747)-C(5))-methyltransferase RlmC -
  ACDK45_RS03325 (ACDK45_03325) nagZ 645298..646353 (-) 1056 WP_021034786.1 beta-N-acetylhexosaminidase -
  ACDK45_RS03330 (ACDK45_03330) - 646357..646707 (-) 351 WP_005647993.1 YcfL family protein -
  ACDK45_RS03335 (ACDK45_03335) hinT 646707..647057 (-) 351 WP_005627389.1 purine nucleoside phosphoramidase -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25151.85 Da        Isoelectric Point: 6.8375

>NTDB_id=1040087 ACDK45_RS03315 WP_005647998.1 643091..643765(+) (crp) [Haemophilus influenzae strain NTHi52]
MSNELTEIDEVVTSSQEEATQRDPVLDWFLTHCHLHKYPAKSTLIHAGEDATTLYYVIKGSVMVSSKDDEGKEMILTYLG
AGQFFGEAGLFDEGSKRSAWVKTKTTCEIAEISYKKYRQLIQANPEILMFLTAQLARRLQNTSRQVTNLAFLDVAGRIAQ
TLMNLAKQPEAMTHPDGMQIKITRQEIGQMVGCSRETVGRIIKMLEDQNLIHAHGKTIVVYGAR

Nucleotide


Download         Length: 675 bp        

>NTDB_id=1040087 ACDK45_RS03315 WP_005647998.1 643091..643765(+) (crp) [Haemophilus influenzae strain NTHi52]
ATGTCAAATGAATTAACCGAAATTGATGAAGTTGTAACCTCCTCTCAAGAAGAAGCAACTCAACGAGATCCCGTTTTAGA
TTGGTTTCTTACTCACTGCCATTTGCATAAATATCCTGCAAAATCAACTTTAATTCATGCTGGGGAAGATGCGACCACGC
TGTATTATGTAATTAAAGGTTCTGTAATGGTATCTTCAAAAGATGATGAAGGCAAAGAGATGATCCTCACTTACTTAGGA
GCAGGACAATTTTTTGGCGAAGCGGGATTATTTGATGAAGGTTCAAAACGATCAGCTTGGGTAAAAACAAAAACAACATG
TGAAATTGCTGAAATTTCCTATAAGAAATATCGCCAGTTGATTCAGGCAAACCCTGAAATCTTAATGTTTCTCACTGCAC
AATTGGCAAGACGTTTGCAAAATACATCACGTCAAGTCACGAATTTGGCATTTTTGGACGTCGCAGGTCGCATCGCTCAA
ACTTTAATGAACTTAGCTAAACAGCCTGAAGCAATGACGCATCCTGATGGTATGCAAATCAAAATTACACGCCAAGAAAT
AGGGCAAATGGTGGGTTGTTCACGAGAAACTGTGGGGCGCATTATTAAGATGTTGGAGGATCAGAATCTTATCCACGCTC
ATGGAAAAACAATCGTTGTATATGGCGCAAGATAA

Domains

Predicted by InterproScan.

Cyclic nucleotide-binding domain (cNMP_binding)

(36-124)

Crp-like helix-turn-helix domain (HTH_Crp_2)

(156-220)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q4QLV0

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  crp Haemophilus influenzae Rd KW20

100

100

1
  crp Vibrio cholerae strain A1552

75.49

91.071

0.687
  crp Acinetobacter baumannii D1279779

48.705

86.161

0.42

Multiple sequence alignment