Detailed information NTG1018519

Bioinformatically predicted

Overview

• Name: hexA
• Type: Machinery gene
• Locus tag: DQL34_RS00390
• Genome accession: NZ_LS483339
• Coordinates: 63549..66107 (+)
• Length: 852 a.a.
• NCBI ID: WP_111679079.1
• Uniprot ID: -
• Organism: Streptococcus thermophilus strain NCTC12958
• Function: DNA mismatch repair (predicted from homology) Homologous recombination

Genomic Context

Location: 58549..71107

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQL34_RS00355 (NCTC12958_00076)	-	60082..60267 (+)	186	WP_111679073.1	hypothetical protein	-
DQL34_RS00360 (NCTC12958_00077)	-	60333..60560 (+)	228	WP_223899748.1	hypothetical protein	-
DQL34_RS00365 (NCTC12958_00078)	prx	61041..61229 (+)	189	WP_111679075.1	hypothetical protein	Regulator
DQL34_RS00370 (NCTC12958_00079)	-	61610..62299 (+)	690	WP_197709066.1	DUF3800 domain-containing protein	-
DQL34_RS00380 (NCTC12958_00080)	argR	62769..63197 (+)	429	WP_024704313.1	arginine repressor	-
DQL34_RS00385 (NCTC12958_00081)	-	63197..63556 (+)	360	WP_064355739.1	YlbF family regulator	-
DQL34_RS00390 (NCTC12958_00082)	hexA	63549..66107 (+)	2559	WP_111679079.1	DNA mismatch repair protein MutS	Machinery gene
DQL34_RS00395 (NCTC12958_00083)	-	66141..66596 (-)	456	WP_084825708.1	DUF3021 domain-containing protein	-
DQL34_RS00400 (NCTC12958_00084)	brsR	66593..67030 (-)	438	WP_111679081.1	LytTR family DNA-binding domain-containing protein	Regulator
DQL34_RS00405 (NCTC12958_00085)	-	67209..67514 (+)	306	WP_084830425.1	hypothetical protein	-
DQL34_RS00410 (NCTC12958_00086)	hexB	67566..69509 (+)	1944	WP_011680601.1	DNA mismatch repair endonuclease MutL	Machinery gene
DQL34_RS00415 (NCTC12958_00087)	-	69640..69861 (+)	222	WP_011680602.1	hypothetical protein	-
DQL34_RS00420 (NCTC12958_00088)	ruvA	70013..70603 (+)	591	WP_111679083.1	Holliday junction branch migration protein RuvA	Machinery gene

Sequence

Protein

• Length: 852 a.a.
• Molecular weight: 95456.78 Da
• Isoelectric Point: 4.6973

>NTDB_id=1018519 DQL34_RS00390 WP_111679079.1 63549..66107(+) (hexA) [Streptococcus thermophilus strain NCTC12958]
MAKEKISPGMQQYLDIKENYPDAFLLFRMGDFYELFYDDAIKAAQILEISLTSRNKNADNPIPMAGVPYHSAQAYIDVLV
EMGYKVAIAEQMEDPKQAVGVVKREVVQVITPGTVVDSSKPDSANNFLVAIDKVGSRFGLSYMDVSTGEFFATELDDFSS
VCSEIQNLKAREVVVGYDLLETDEQVLVNQLNLLLSKEIEGYDDVHLIGNSLTDLESSVAGKLLQYVHRTQMRELSHLQK
AQHYEIKDYLQMSYATKSSLDLLENARTGKKHGSLFWLLDETKTAMGMRLLRTWIDRPLVNQATIIERQNIIQVFLDNFF
ERSDLTESLKGVYDIERLASRVSFGKANPKDLIQLGHTLAQVPVIKAILESFNDDALSGLLQELDALPELESLIRLAIDP
DAPATITEGGIIRDGFDETLDKYRKVMSEGTSWIADIEAKEREASGITTLKIDYNRKDGYYFHVTNSNLSLVPDHFFRKA
TLKNSERFGTAELAKIEGEMLEAREKSSTLEYDIFMRVREQVERYIDRLQSLAKAIATVDVLQSLAVTAEKNHYVRPVFN
DEHRIAIDRGRHAVVEKVMGVQEYIPNTITFDSQTNIQLITGPNMSGKSTYMRQLALSVVMAQMGAYVPADSVDLPIFDA
IYTRIGAADDLISGQSTFMVEMLEANQAIKRATPNSLIIFDELGRGTATYDGMALAQSIIEFIHDKVGAKTMFATHYHEL
TALSNSLTHLVNVHVATLEKDGEVTFLHKIVDGPADKSYGIHVAKIAGLPIDLLNRADTILTQLEGETVVIQPQEKVSSQ
EKPAIETHVNEQISLFGDFTENPVLQELRDLDIYNMTPMQVMMAVADLKQKL

Nucleotide

• Length: 2559 bp

>NTDB_id=1018519 DQL34_RS00390 WP_111679079.1 63549..66107(+) (hexA) [Streptococcus thermophilus strain NCTC12958]
ATGGCTAAGGAAAAAATATCTCCAGGAATGCAGCAGTATTTGGATATCAAGGAAAATTATCCAGATGCTTTTTTGCTGTT
TCGGATGGGGGATTTTTACGAATTATTTTACGATGATGCTATTAAGGCTGCCCAGATTTTAGAAATTAGCCTAACTAGCC
GTAATAAGAATGCAGATAATCCCATTCCTATGGCAGGTGTGCCTTATCATTCAGCTCAAGCATACATTGATGTTTTGGTT
GAGATGGGCTACAAGGTAGCCATTGCTGAGCAGATGGAGGATCCTAAGCAGGCTGTCGGTGTGGTAAAGCGTGAGGTTGT
TCAGGTTATCACACCAGGTACAGTGGTTGACAGCTCTAAACCTGATAGTGCCAACAATTTCTTGGTGGCCATTGACAAGG
TTGGAAGTCGTTTTGGTCTTTCCTATATGGATGTGTCAACGGGTGAATTTTTTGCGACGGAGTTAGATGATTTTAGTTCA
GTTTGTAGTGAAATTCAGAACCTTAAGGCGCGTGAAGTAGTGGTTGGATATGATCTACTTGAAACTGACGAACAAGTTTT
AGTGAACCAACTTAACCTACTTCTCTCCAAGGAAATAGAAGGTTACGATGATGTTCACTTGATTGGTAATAGCTTGACAG
ATTTGGAAAGCAGTGTGGCGGGTAAACTTCTCCAGTATGTTCATCGCACTCAGATGCGTGAGCTCAGTCATTTACAAAAA
GCTCAGCACTATGAGATAAAGGATTACTTGCAGATGTCCTATGCGACCAAGTCAAGCTTGGATTTACTGGAAAATGCTAG
AACGGGCAAGAAACACGGTTCTCTTTTCTGGCTCTTGGATGAAACCAAGACAGCCATGGGAATGCGTCTCTTGCGAACTT
GGATTGATCGTCCTTTAGTGAATCAAGCCACCATCATAGAGCGTCAGAATATTATCCAAGTTTTCTTGGACAATTTCTTT
GAACGTAGTGACTTGACCGAGAGTCTAAAAGGTGTTTACGATATTGAGCGTCTGGCCAGTCGTGTTTCCTTTGGCAAGGC
TAATCCTAAAGATTTGATTCAGCTAGGTCATACCTTAGCTCAGGTTCCGGTCATTAAGGCAATCTTGGAGTCCTTTAATG
ACGATGCCTTGTCAGGTCTTTTACAAGAGTTAGATGCTTTGCCAGAATTAGAGAGTTTGATTCGTTTGGCTATTGATCCT
GATGCTCCAGCAACAATTACAGAAGGTGGTATTATCCGTGATGGTTTTGATGAGACCTTGGACAAGTATCGCAAAGTGAT
GAGCGAGGGGACGTCATGGATTGCGGATATCGAAGCCAAAGAACGTGAAGCGTCTGGTATTACAACACTAAAAATTGATT
ATAACCGTAAAGATGGTTATTATTTCCATGTGACCAACTCTAACCTTAGCTTGGTTCCTGACCATTTCTTCCGTAAGGCG
ACACTGAAAAATTCGGAGCGTTTTGGAACTGCTGAGTTGGCTAAGATTGAAGGTGAAATGCTAGAAGCGCGTGAAAAATC
GTCAACCCTAGAGTATGATATTTTCATGCGTGTCCGTGAGCAAGTTGAACGCTATATCGACCGTTTGCAGTCTTTGGCTA
AGGCCATTGCGACAGTCGATGTGCTTCAGAGTTTGGCTGTTACAGCGGAGAAAAATCATTATGTTCGTCCTGTTTTTAAT
GATGAGCATCGTATCGCTATTGATCGGGGCCGTCATGCGGTGGTTGAGAAGGTTATGGGCGTTCAGGAATACATTCCAAA
TACGATTACCTTTGACAGTCAGACCAATATTCAGCTCATCACAGGACCAAATATGAGTGGTAAATCTACCTATATGCGGC
AGTTAGCCTTGTCAGTAGTTATGGCTCAAATGGGGGCTTACGTACCAGCAGATAGTGTTGATTTACCAATTTTTGACGCC
ATCTATACACGTATAGGTGCCGCAGATGACCTGATTTCAGGTCAGTCGACCTTCATGGTTGAGATGCTGGAGGCTAATCA
GGCCATTAAGCGAGCGACACCTAATTCCTTGATTATTTTTGATGAGTTGGGGCGTGGGACAGCCACTTATGATGGTATGG
CTTTGGCCCAGTCTATTATTGAGTTTATTCATGACAAGGTGGGGGCTAAGACCATGTTTGCTACCCATTATCATGAGTTG
ACTGCGCTATCAAACAGTTTGACACACCTTGTCAACGTCCATGTTGCGACACTTGAAAAGGATGGCGAAGTGACTTTCCT
CCACAAAATTGTCGATGGTCCAGCTGATAAATCTTATGGTATTCATGTAGCTAAAATTGCAGGTTTACCAATAGATTTAT
TGAACCGTGCTGACACCATATTGACACAATTAGAAGGAGAGACAGTTGTAATCCAACCTCAGGAAAAGGTATCGTCTCAA
GAAAAGCCTGCCATTGAAACGCATGTCAACGAGCAAATCTCTCTCTTTGGTGACTTTACTGAAAATCCAGTTCTTCAAGA
GTTGCGTGATTTGGACATTTACAACATGACACCGATGCAAGTCATGATGGCTGTAGCAGATTTAAAACAGAAACTATAA

Domains

Predicted by InterProScan.

• MutS domain I (MutS_I) (8-118)

• MutS family domain IV (MutS_IV) (415-505)

• MutS domain II (MutS_II) (126-239)

• MutS domain III (MutS_III) (256-546)

• MutS domain V (MutS_V) (599-785)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
hexA	Streptococcus pneumoniae R6	73.474	100	0.735
mutS	Pseudomonas stutzeri strain ATCC 17587	36.133	100	0.369