Detailed information NTG0100219

Bioinformatically predicted

Overview

• Name: covS
• Type: Regulator
• Locus tag: AACH29_RS02220
• Genome accession: NZ_AP027239
• Coordinates: 450294..451784 (+)
• Length: 496 a.a.
• NCBI ID: WP_014024351.1
• Uniprot ID: A0AA46TWW1
• Organism: Lactococcus garvieae strain L21-12
• Function: repress the expression of comX (predicted from homology) Competence regulation

Genomic Context

Location: 445294..456784

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
AACH29_RS02195 (LG21E12_04270)	pfkB	445441..446367 (+)	927	WP_004259111.1	1-phosphofructokinase	-
AACH29_RS02200 (LG21E12_04280)	-	446382..448286 (+)	1905	WP_014024348.1	fructose-specific PTS transporter subunit EIIC	-
AACH29_RS02205 (LG21E12_04290)	-	448398..448640 (+)	243	WP_003135050.1	type B 50S ribosomal protein L31	-
AACH29_RS02210 (LG21E12_04300)	-	448857..449408 (+)	552	WP_014024349.1	YceD family protein	-
AACH29_RS02215 (LG21E12_04310)	covR	449510..450205 (+)	696	WP_004259096.1	response regulator transcription factor	Regulator
AACH29_RS02220 (LG21E12_04320)	covS	450294..451784 (+)	1491	WP_014024351.1	HAMP domain-containing histidine kinase	Regulator
AACH29_RS02225 (LG21E12_04330)	-	452181..453752 (+)	1572	WP_014024352.1	ABC transporter permease subunit	-
AACH29_RS02230 (LG21E12_04340)	-	453753..454490 (+)	738	WP_014024353.1	amino acid ABC transporter ATP-binding protein	-
AACH29_RS02235 (LG21E12_04350)	murD	454629..455990 (+)	1362	WP_014024354.1	UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase	-

Sequence

Protein

• Length: 496 a.a.
• Molecular weight: 56753.73 Da
• Isoelectric Point: 5.1966

>NTDB_id=100219 AACH29_RS02220 WP_014024351.1 450294..451784(+) (covS) [Lactococcus garvieae strain L21-12]
MVKFFDSKKKKTESLPERKRSIMLRWAFANTIFCFITFTIFTVLVYQLTITTFINSEKEDMMKALDNVEQSLSQSESTLS
EENLANYLAYAKDYTASSQGKENELETLGSMIGSRKSFYVFDVGENLIYSTNSHGFPLKKDVGDGTHAVRTFGEYSGYLV
ERPVYSNKTGKLIGYVQAFYDMSYYYSVRTKLLIALIILEIIALFIAQFVGYFMASRYIKPLERLHDAITTRANNLKADF
KPVVIQTGDEIEELATVYNDMMIKLNDYVDQQKRFVSDVSHELRTPLAVLDGHLNLLNRWGKNDPEVLEESLQASIEEVS
TMRTMLEEMLALARLENIDFQDEDLICDPTEVSNFLKKNFLLIHADLSLTVENNLSPGRLAHIYPNHYEQGLKILIDNAI
KYSPKDRQEVKIHLEEDDKYIITTVEDHGYGISQEDLKHVFERFFRADKARNRDIGGTGLGLSIIQRIVENYDGDVSVTS
VVGEGSKFTLKIPKIK

Nucleotide

• Length: 1491 bp

>NTDB_id=100219 AACH29_RS02220 WP_014024351.1 450294..451784(+) (covS) [Lactococcus garvieae strain L21-12]
ATGGTAAAATTTTTTGATTCGAAGAAGAAAAAAACAGAAAGTCTTCCCGAGCGTAAGCGAAGCATCATGCTCCGTTGGGC
ATTTGCAAATACGATTTTTTGTTTTATTACCTTCACTATTTTTACAGTATTGGTTTATCAATTGACCATTACAACCTTCA
TCAATTCTGAAAAAGAGGATATGATGAAAGCTCTGGATAATGTTGAGCAAAGTTTGTCCCAATCGGAAAGCACACTGTCG
GAAGAAAATCTGGCGAATTATTTGGCTTATGCCAAAGACTATACAGCCTCCAGTCAGGGAAAAGAAAATGAGCTAGAAAC
ACTTGGAAGTATGATTGGCTCTAGGAAGTCCTTTTATGTTTTTGACGTCGGTGAAAATTTGATTTACTCGACCAATTCGC
ATGGCTTCCCTCTAAAAAAAGACGTGGGGGATGGCACTCATGCTGTACGTACATTTGGTGAATATTCTGGTTATTTGGTC
GAACGACCGGTTTATTCTAATAAAACAGGTAAGCTGATTGGCTATGTGCAGGCTTTCTATGATATGAGTTATTATTATAG
CGTGCGAACAAAGTTACTGATTGCCCTGATTATCCTAGAAATTATTGCTCTCTTTATCGCTCAGTTTGTTGGTTATTTTA
TGGCGAGTCGTTACATCAAGCCTCTAGAACGGTTGCACGATGCGATTACTACACGTGCCAATAACTTGAAGGCGGATTTC
AAACCTGTAGTGATTCAAACAGGTGATGAAATTGAAGAACTGGCGACTGTTTATAATGACATGATGATCAAGCTTAACGA
TTATGTTGATCAGCAGAAACGTTTTGTTTCTGATGTCAGTCACGAGTTACGTACGCCACTTGCGGTTTTGGATGGTCATT
TGAATCTCTTGAACCGTTGGGGGAAAAACGATCCTGAGGTGCTTGAGGAGTCTTTACAGGCCAGTATAGAAGAAGTGAGT
ACGATGAGAACGATGTTGGAAGAGATGCTTGCATTGGCCCGTCTTGAAAACATTGATTTTCAAGATGAAGACCTTATCTG
TGATCCAACAGAAGTTTCTAATTTCCTTAAGAAAAACTTCCTACTTATCCATGCTGATTTAAGCTTAACTGTGGAAAATA
ACTTGTCACCGGGAAGATTGGCTCATATCTATCCCAACCATTATGAACAAGGCTTAAAAATTTTGATTGATAATGCGATA
AAATACTCGCCTAAAGATCGCCAAGAAGTGAAAATCCATCTAGAAGAAGATGATAAATACATTATCACTACGGTTGAGGA
TCATGGCTATGGCATTAGTCAGGAAGATTTAAAACATGTCTTTGAGCGTTTCTTCCGTGCTGATAAAGCGCGAAATCGGG
ATATAGGAGGCACTGGGCTTGGACTGTCTATTATCCAACGCATAGTGGAAAACTATGATGGGGATGTCAGTGTGACTTCT
GTTGTAGGTGAGGGATCGAAATTCACTTTAAAAATTCCTAAGATTAAATAA

Domains

Predicted by InterproScan.

• His Kinase A (phospho-acceptor) domain (HisKA) (272-337)

• ArlS sensor domain (ArlS_N) (52-190)

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (389-494)

• HAMP domain (HAMP) (214-266)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
covS	Lactococcus lactis subsp. lactis strain DGCC12653	55.936	100	0.56