88861

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 51085..51349 Replicon plasmid tig00000311
Accession NZ_CP024854
Organism Escherichia coli strain AR_0006

Toxin (Protein)


Gene name pndA Uniprot ID U9Y6M3
Locus tag AM333_RS27640 Protein ID WP_001331364.1
Coordinates 51197..51349 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name pndB
Locus tag -
Coordinates 51085..51147 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM333_RS27625 46324..48615 - 2292 WP_001289276.1 hypothetical protein -
AM333_RS27630 48608..49678 - 1071 WP_000151583.1 IncI1-type conjugal transfer protein TrbB -
AM333_RS27635 49697..50905 - 1209 WP_000121273.1 IncI1-type conjugal transfer protein TrbA -
- 51085..51147 - 63 NuclAT_0 - Antitoxin
- 51085..51147 - 63 NuclAT_0 - Antitoxin
- 51085..51147 - 63 NuclAT_0 - Antitoxin
- 51085..51147 - 63 NuclAT_0 - Antitoxin
AM333_RS27640 51197..51349 + 153 WP_001331364.1 Hok/Gef family protein Toxin
AM333_RS27645 51421..51672 - 252 WP_001291964.1 hypothetical protein -
AM333_RS28450 52331..52507 - 177 WP_001054897.1 hypothetical protein -
AM333_RS27650 52899..53108 + 210 WP_000062603.1 HEAT repeat domain-containing protein -
AM333_RS27655 53180..53830 - 651 WP_001178506.1 plasmid IncI1-type surface exclusion protein ExcA -
AM333_RS27660 53904..56072 - 2169 WP_000698357.1 DotA/TraY family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Conjugative plasmid blaCMY-2 - 1..96413 96413


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(7-46)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5775.13 Da        Isoelectric Point: 8.7948

>T88861 WP_001331364.1 NZ_CP024854:51197-51349 [Escherichia coli]
MPQRTFLMMLIVICVTILCFVWMVRDSLCGLRLQQGNTVLVATLAYEVKR

Download         Length: 153 bp

>T88861 NZ_CP024854:51197-51349 [Escherichia coli]
ATGCCACAGCGAACGTTTTTAATGATGTTAATCGTCATCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGGACTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA

Antitoxin


Download         Length: 63 bp

>AT88861 NZ_CP024854:c51147-51085 [Escherichia coli]
TCGAAGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5W9M382

Antitoxin

Download structure file

References